Prognostic factors in survival of colorectal cancer patients after surgery

Abstract

Age, TNM stage, T-status, nodal status, distant metastasis, grade, lymphatic and vascular invasion and presurgery CEA level can predict the postsurgical survival rate in patients with colorectal cancer.

Preoperative Carcinoembryonic Antigen and Prognosis of Colorectal Cancer. An Independent Prognostic Factor Still Reliable

“…11 These observations, which were made as recently as 2013 and which still seem surprising after 30 years, are certainly not due to the lack of testing new molecular, genetic, or humoral markers, but to the fact that these are not reliable, simple, nor cost effective as the CEA could be. In recent years, we are not the only ones 1,3,4,6,7,10,11,16,18,19,[27][28][29] who believe that the determination of the p-CEA has a prognostic value in identifying, preoperatively, the group of patients who most likely will show recurrences. In fact, p-CEA is able to identify both patients whose understaging results from occult metastasis and those who are carriers of histologically advanced or more aggressive neoplasms.…”

“…At present, these markers still have not found a regular application due to the complexity of their determination, the difficulty of standardization and, last but not least, the low cost-benefit ratio. 1,3,4,9,10 With this in mind, in our opinion, the carcinoembryonic antigen (CEA) maintains its position, as for over 30 years it has continued to be the most widely used marker 11 and whose validity, with regard to colorectal follow-up, has been sanctioned by leading organizations such as the American Society of Clinical Oncology (ASCO) 12 and the European Group on Tumor Markers. 13 Moreover, as Herrera 14 and Wanebo 15 had already reported by the end of the '70s, the preoperative determination of the CEA (p-CEA) seems to be related both to the staging of colorectal neoplasia and to the patient's prognosis.…”

“…Forty percent of these will have a poor prognosis for which targeted therapeutic strategies could most likely be more effective. [1][2][3] For this reason, finding prognostic factors that are early, reliable, and related to the extent of the tumor is of the utmost importance. Among these, the most that are considered even to this day are T and N parameters.…”

An Overview of Clinical and Pathological Characteristics and Survival Rate of Colorectal Cancer in Iran

“…In addition, the median overall survival in 5 studies with 4746 patients was 55.2 months (range: 42-94.5). Besides, the average 1-, 2-, 3-, 4-, 5-, 10-, and 15-year overall survival rates were 85.9%, 74%, 64.9%, 55.3%, 52.5%, 47.9%, and 25.9%, respectively (11,26,29,(31)(32)(33)(34)(36)(37)(38)(39) (Table 3). …”

“…By adding the rectosigmoid junction to rectal primary site, the mean proportion of the rectum as the primary site increased to 42%. Only 4 studies, including 7561 patients provided a detailed information regarding the sublocation of colon primary site as follows: Sigmoid colon 43%, ascending clon 21%, cecum 21%, descending colon 12%, and transverse colon 3% (11,13,15,16,(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). Out of the scope of the study (n = 21)a Eligible articles for review (n=27) a, Screening and diagnostic methods and colorectal polyps were the most frequent in this category.…”