Prognostic Factors in Testicular Germ Cell Tumours Experiences from 1058 Consecutive Cases

Væth, Michael; Schultz, Henrik; Maase, Hans von der; Engelholm, Silke; Jacobsen, Grete Krag; Nørgaard‐Pedersen, Bent; Group, Dateca Study

doi:10.3109/02841868409136023

Cited by 24 publications

(2 citation statements)

References 16 publications

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“…Regarding tumour features, nearly all cases (32/33) of mixed GCTs with choriocarcinoma were unilateral without a specific predilection regarding laterality, in line with prior data 20 . Our results also corroborate previous studies suggesting that choriocarcinoma in mixed GCTs is a risk factor for an aggressive tumour phenotype characterized by high grade and metastasis at presentation 12 , 21 . Of the 1001 testicular cancer cases in our study, 3.3% were mixed GCTs with a choriocarcinoma component, of which almost half (45.5%) were grade IV anaplastic lesions and metastatic at the time of diagnosis, resulting in a mortality rate of 15% (5/33 patients).…”

Section: Discussionsupporting

confidence: 92%

A decade in focus: mixed germ cell tumors with choriocarcinoma components

Al-Khayal,

Noureldin,

Alghafees

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction: This 10-year registry review aimed to investigate the clinical behaviour and outcomes of mixed germ cell tumours with choriocarcinoma components, a rare and aggressive subtype of testicular cancer, in Saudi Arabia. The study explores the demographic characteristics of affected patients, tumour profiles, and the mortality rate associated with this malignancy. Methods: Utilizing data from the Saudi Cancer Registry, the authors identified 33 cases of mixed germ cell tumours with choriocarcinoma components among 1001 testicular cancer cases recorded between 2008 and 2017. Demographic information, including age, marital status, region of residency, year of diagnosis, and 10-year survival status, were collected. Tumour factors, such as the basis of diagnosis, origin site, behaviour, grade, extension, and laterality, were also analyzed. Results: The majority of cases (78.8%) occurred in the young age group (18–45 years), and most tumours (97%) originated in normally descended testes. Grade IV (undifferentiated anaplastic) tumours and distant metastasis were present in 45.5% of patients. All cases exhibited malignant tumour behaviour. The overall mortality rate was 15%, with a mean time from diagnosis to death of 7.72 months (range: 0.5–21.5 months). Conclusion: Mixed germ cell tumours with choriocarcinoma components are rare and tend to affect younger populations. These tumours demonstrate aggressive clinical behaviour, with a significant proportion presenting with high-grade lesions and metastasis at diagnosis. The observed mortality rate underscores the poor prognosis associated with this malignancy. Our study provides essential insights into the clinical characteristics of this rare tumour subtype in the Saudi Arabian population, emphasizing the need for further research to identify prognostic factors and optimize management strategies for affected patients.

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Section: Discussionsupporting

confidence: 92%

A decade in focus: mixed germ cell tumors with choriocarcinoma components

Al-Khayal,

Noureldin,

Alghafees

et al. 2023

Annals of Medicine &Amp; Surgery

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“…The possible prognostic significance of various tumour types and histologic features in the present series are dealt with in the report by VKTH et coll. (20). However, investigation of the prognostic significance of the various histologic subtypes has been rendered highly difficult by the success of combination chemotherapy and only very great differences can be expected to stand out clearly.…”

Section: Discussionmentioning

confidence: 99%

Testicular Germ Cell Tumours in Denmark 1976–1980 Pathology of 1058 Consecutive Cases

G¹,

Barlebo²,

Olsen³

et al. 1984

Acta Radiologica: Oncology

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170

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Intestinal hemorrhages in patients with a nonseminomatous testicular tumor

Plukker

Koops

Sleijfer

et al. 1991

Cancer

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This article reports on three patients with intestinal bleeding due to metastases from a nonseminomatous testicular tumor (NSTT) to the gastrointestinal tract. Involvement of the gastrointestinal tract is rare. The mode of spread is either by hematogenous dissemination or by direct extension from involved paraaortic lymph nodes. The symptoms of these patients are briefly described. Early recognition and efficient supportive care are essential in the management of such patients. Cancer 68:2630–2632, 1991.

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Prognostic Factors in Testicular Germ Cell Tumours Experiences from 1058 Consecutive Cases

Cited by 24 publications

References 16 publications

A decade in focus: mixed germ cell tumors with choriocarcinoma components

A decade in focus: mixed germ cell tumors with choriocarcinoma components

Testicular Germ Cell Tumours in Denmark 1976–1980 Pathology of 1058 Consecutive Cases

Intestinal hemorrhages in patients with a nonseminomatous testicular tumor

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