Prognostic Factors in the Uveitis of Juvenile Rheumatoid Arthritis

Wolf, Mitchell D.; Lichter, Paul R.; Ragsdale, Carol Godoshian

doi:10.1016/s0161-6420(87)80007-6

Cited by 191 publications

(100 citation statements)

References 24 publications

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“…We believe that uveitis is a severe complication of the disease, not simply in terms of its functional threat (band keratopathy, glaucoma, or cataract, which are tightly linked to late discovery of uveitis), but also in terms of its chronicity and long-term treatment constraints. We found that the presence of ANA did not predispose oligoarticularonset JIA patients to chronic uveitis, in contrast to that found in previous studies (25,40), and we frequently observed ANA positivity after uveitis occurrence. These observations indicate that the relationship between ANA and uveitis is far from clear-cut; the strong association between ANA positivity and uveitis reported in previous studies (25,(39)(40)(41) is not sufficient to warrant the use of ANA positivity as a prognostic factor.…”

Section: Discussioncontrasting

confidence: 98%

“…We found that the presence of ANA did not predispose oligoarticularonset JIA patients to chronic uveitis, in contrast to that found in previous studies (25,40), and we frequently observed ANA positivity after uveitis occurrence. These observations indicate that the relationship between ANA and uveitis is far from clear-cut; the strong association between ANA positivity and uveitis reported in previous studies (25,(39)(40)(41) is not sufficient to warrant the use of ANA positivity as a prognostic factor. Our results suggest that whatever the results of ANA tests, children should be examined as frequently as every 3 months by an ophthalmologist.…”

Section: Discussioncontrasting

confidence: 98%

See 1 more Smart Citation

Long-term outcome and prognosis in oligoarticular-onset juvenile idiopathic arthritis

Guillaume¹,

Prieur²,

Coste³

et al. 2000

Arthritis & Rheumatism

181

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Objective. To describe the long-term outcome and determine predictors of severity among patients with oligoarticular-onset juvenile idiopathic arthritis (JIA).Methods. In a longitudinal study, 207 patients with oligoarticular-onset JIA who were referred between 1988 and 1998 were evaluated. At disease onset, selected clinical and laboratory data were collected as independent variables. A polyarticular disease course, joint erosion, uveitis, and remission were assessed as dependent variables. Longitudinal analyses were performed with the Kaplan-Meier method, and multivariate analysis with the Cox model.Results. After 6 years of followup, the probability of a polyarticular course of disease was 50%, joint erosion was 35%, uveitis was 30%, and remission was 23% in these patients. Joint erosion was strongly associated with a polyarticular course. A high erythrocyte sedimentation rate (ESR) as well as involvement of more than 1 joint or involvement of an upper limb at disease onset were predictors of disease extension. A high ESR was also a strong predictor of a destructive course, and a family history of psoriasis was predictive of uveitis occurrence. No predictive factor for remission could be identified.Conclusion. Oligoarticular-onset JIA is a severe disease with frequent complications. Factors predictive of severity in oligoarticular-onset JIA were identified. This could allow early identification of high-risk patient subgroups, warranting a more aggressive therapeutic approach.

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Section: Discussioncontrasting

confidence: 98%

Section: Discussioncontrasting

confidence: 98%

Long-term outcome and prognosis in oligoarticular-onset juvenile idiopathic arthritis

Guillaume¹,

Prieur²,

Coste³

et al. 2000

Arthritis & Rheumatism

181

View full text Add to dashboard Cite

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“…2 The risk of cataract formation in JIA-associated uveitis increases when posterior synechia are present at the initial examination and with treatment with a high dose of systemic corticosteroids. 3 Previously, the visual outcome of cataract surgery in JIA-associated uveitis was poor. Since new surgical techniques have been recommended, the results of cataract extraction (CE) have improved, but surgery in uveitic eyes of children still remains challenging.…”

mentioning

confidence: 99%

Risk Factors for the Development of Cataract Requiring Surgery in Uveitis Associated with Juvenile Idiopathic Arthritis

Sijssens

Rothová

Vijver

et al. 2007

American Journal of Ophthalmology

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• PURPOSE: To identify the possible risk factors for the development of cataract requiring surgery in children with juvenile idiopathic arthritis (JIA)-associated uveitis.• DESIGN: Retrospective cohort study.• METHODS: Data of 53 children with JIA-associated uveitis, of whom 27 had undergone cataract extraction (CE), were obtained. The main outcome measure, the interval between the onset of uveitis and the first CE (U-CE interval), was examined in relation to clinical and ophthalmologic characteristics and treatment strategies before CE. 2 The risk of cataract formation in JIA-associated uveitis increases when posterior synechia are present at the initial examination and with treatment with a high dose of systemic corticosteroids. 3 Previously, the visual outcome of cataract surgery in JIA-associated uveitis was poor. Since new surgical techniques have been recommended, the results of cataract extraction (CE) have improved, but surgery in uveitic eyes of children still remains challenging. 4 The aim of our study was to evaluate which factors accelerate the development of cataract requiring surgery in JIA-associated uveitis. Therefore, clinical and ophthalmologic characteristics and the treatment strategies in children with JIA-associated uveitis were investigated in relation to the interval between the diagnosis of uveitis and the first cataract extraction (U-CE interval). METHODS WE REVIEWED THE MEDICAL RECORDS OF 53 CHILDRENwith JIA-associated uveitis (n ϭ 51) or antinuclear antibody (ANA)-positive uveitis without arthritis (n ϭ 2) diagnosed before the age of 16 years. These children represent all children with JIA-associated uveitis identified in a complete database search of the FC Donders

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“…A remarkable difference in the frequency of secondary glaucoma was noted between the two groups (45% in the former and 17% in the latter). 26 Similarly, Neri et al found posterior synechiae to be present more frequently in patients with secondary glaucoma. 17 In the same study, 14.5% patients with chronic uveitis without glaucoma had a deterioration of the best corrected visual acuity (BCVA).…”

Section: Severity Of Uveitismentioning

confidence: 93%

Uveitis and Glaucoma: A Critical Review

Mahajan¹,

Venkatesh²,

Garg³

2011

JOCGP

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Raised intraocular pressure is a frequently encountered complication of uveitis. Intraocular homeostasis, maintained by the impermeable blood-ocular barrier, is important to guarantee optimal visual function. During uveitis breakdown of the blood-ocular barrier occurs, allowing the influx of proteins as well as inflammatory and immunocompetent cells. The combination of action of inflammatory cells and the mediators they release; and the chronic corticosteroid therapy used to treat the uveitis can participate in the pathogenesis of uveitic glaucoma. These factors alter the normal anatomic structure of the anterior chamber and angle. Management of uveitic glaucoma may be difficult because of the numerous mechanisms involved in its pathogenesis and is guided by careful delineation of the pathophysiology involved in each individual case. This article reviews, in detail, the pathogenesis of uveitic glaucoma and its therapies, with emphasis on the recent developments in the subject.

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Prognostic Factors in the Uveitis of Juvenile Rheumatoid Arthritis

Cited by 191 publications

References 24 publications

Long-term outcome and prognosis in oligoarticular-onset juvenile idiopathic arthritis

Long-term outcome and prognosis in oligoarticular-onset juvenile idiopathic arthritis

Risk Factors for the Development of Cataract Requiring Surgery in Uveitis Associated with Juvenile Idiopathic Arthritis

Uveitis and Glaucoma: A Critical Review

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