Prognostic factors including lymphovascular invasion on survival for resected non–small cell lung cancer

Okiror, Lawrence; Harling, Leanne; Toufektzian, Levon; King, Juliet; Routledge, Tom; Harrison-Phipps, Karen; Pilling, John; Veres, Lukács; Lal, R; Billè, Andrea

doi:10.1016/j.jtcvs.2018.02.108

Cited by 37 publications

(27 citation statements)

References 45 publications

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“…Both literature and our own experimental data show that lung cancer is usually detected at advanced stages, while the proportion of early cancer (T 1-2 N 0 M 0 ) is 28% according to our data [3]. Survival analysis clearly demonstrates that overall survival is statistically significantly dependent on tumor size, the presence/absence of regional and distant metastases, while the dependence on the histological type of lung cancer is less pronounced [4].…”

Section: Introductionsupporting

confidence: 68%

Biochemical Markers of Saliva in Lung Cancer: Diagnostic and Prognostic Perspectives

et al. 2020

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The aim of the work is to study the metabolic characteristics of saliva in lung cancer for use in early diagnosis and determining the prognosis of the disease. The patient group included 425 lung cancer patients, 168 patients with non-cancerous lung diseases, and 550 healthy volunteers. Saliva samples were collected from all participants in the experiment before treatment and 34 biochemical saliva parameters were determined. Participants were monitored for six years to assess survival rates. The statistical analysis was performed by means of Statistica 10.0 (StatSoft) program and R package (version 3.2.3). To construct the classifier, the Random Forest method was used; the classification quality was assessed using the cross-validation method. Prognostic factors were analyzed by multivariate analysis using Cox’s proportional hazard model in a backward step-wise fashion to adjust for potential confounding factors. A complex of metabolic changes occurring in saliva in lung cancer is described. Seven biochemical parameters were identified (catalase, triene conjugates, Schiff bases, pH, sialic acids, alkaline phosphatase, chlorides), which were used to construct the classifier. The sensitivity and specificity of the method were 69.5% and 87.5%, which is practically not inferior to the diagnostic characteristics of markers routinely used in the diagnosis of lung cancer. Significant independent factors in the poor prognosis of lung cancer are imidazole compounds (ICs) above 0.478 mmol/L and salivary lactate dehydrogenase activity below 545 U/L. Saliva has been shown to have great potential for the development of diagnostic and prognostic tests for lung cancer.

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Section: Introductionsupporting

confidence: 68%

Biochemical Markers of Saliva in Lung Cancer: Diagnostic and Prognostic Perspectives

et al. 2020

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“…Traditional tumor characteristics such as differentiation, tumor invasion, lymph node metastasis, and TNM (Tumor, Nodes, and Metastasis) stage classification are not the only aspects that determine the prognosis of the disease [12][13][14]. For prognostic purposes, the use of several groups of biomarkers is described.…”

Section: Discussionmentioning

confidence: 99%

Survival Rates of Patients with Non-Small Cell Lung Cancer Depending on Lymph Node Metastasis: A Focus on Saliva

2021

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The aim of this study was to compare overall survival (OS) rates at different pN stages of NSCLC depending on tumor characteristics and to assess the applicability of saliva biochemical markers as prognostic signs. The study included 239 patients with NSCLC (pN0-120, pN1-51, pN2-68). Saliva was analyzed for 34 biochemical indicators before the start of treatment. For pN0, the tumor size does not have a prognostic effect, but the histological type should be taken into account. For pN1 and pN2, long-term results are significantly worse in squamous cell cancer with a large tumor size. A larger volume of surgical treatment reduces the differences between OS. The statistically significant factors of an unfavorable prognosis at pN0 are the lactate dehydrogenase activity <1294 U/L and the level of diene conjugates >3.97 c.u. (HR = 3.48, 95% CI 1.21–9.85, p = 0.01541); at pN1, the content of imidazole compounds >0.296 mmol/L (HR = 6.75, 95% CI 1.28–34.57, p = 0.00822); at pN2 levels of protein <0.583 g/L and Schiff bases >0.602 c.u., as well as protein >0.583 g/L and Schiff bases <0.602 c.u. (HR = 2.07, 95% CI 1.47–8.93, p = 0.04351). Using salivary biochemical indicators, it is possible to carry out stratification into prognostic groups depending on the lymph node metastasis.

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“…These CT features also predicted RFS, independent of clinical T category (T1b/T1c vs T1a) and surgical approach (segmentectomy vs wedge resection). pLVI is well-recognized as an important prognostic factor for NSCLC [1,7,9,10]. Yet, LVI is not incorporated in the current TNM staging system.…”

Section: Discussionmentioning

confidence: 99%

“…Lymphovascular invasion (LVI) is a high-risk pathologic feature in NSCLC and is significantly associated with both an increased risk of distant metastasis and shorter survival [7][8][9][10]. Some studies maintain that adjuvant chemotherapy is needed for patients with LVI, even in stage I disease [5,11].…”

Section: Accepted Manuscript Introductionmentioning

confidence: 99%

Sublobar Resection in Stage IA Non–Small Cell Lung Cancer: Role of Preoperative CT Features in Predicting Pathologic Lymphovascular Invasion and Postoperative Recurrence

Choe

Kim

Yun

et al. 2021

American Journal of Roentgenology

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The publication of this Accepted Manuscript is provided to give early visibility to the contents of the article, which will undergo additional copyediting, typesetting, and review before it is published in its final form. During the production process, errors may be discovered that could affect the content of the Accepted Manuscript. All legal disclaimers that apply to the journal pertain. The reader is cautioned to consult the definitive version of record before relying on the contents of this document.

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Prognostic factors including lymphovascular invasion on survival for resected non–small cell lung cancer

Abstract: Lymphovascular invasion is associated with a worse overall survival in patients with resected non-small cell lung cancer regardless of tumor stage. Parietal pleural involvement, N2 nodal disease, and advanced age independently predict poor overall survival.

Cited by 37 publications

References 45 publications

Biochemical Markers of Saliva in Lung Cancer: Diagnostic and Prognostic Perspectives

Biochemical Markers of Saliva in Lung Cancer: Diagnostic and Prognostic Perspectives

Survival Rates of Patients with Non-Small Cell Lung Cancer Depending on Lymph Node Metastasis: A Focus on Saliva

Sublobar Resection in Stage IA Non–Small Cell Lung Cancer: Role of Preoperative CT Features in Predicting Pathologic Lymphovascular Invasion and Postoperative Recurrence

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