Prognostic factors indicating survival with native liver after Kasai procedure for biliary atresia

Obayashi, Juma; Kawaguchi, Kohei; Manabe, Shutaro; Nagae, Hideki; Wakisaka, Munechika; Koike, Junki; Takagi, Masayuki; Kitagawa, Hiroaki

doi:10.1007/s00383-017-4135-y

Cited by 13 publications

(9 citation statements)

References 18 publications

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“…Патоморфологическое исследование биоптатов печени является наиболее чувствительным и досто-верным методом ранней диагностики билиарной атрезии, что имеет большое значение для успешного исхода оперативного лечения. Такого мнения придерживаются многие авторы [16,33,35,36,37,38].…”

Section: диагностикаunclassified

Modern Approaches to the Surgical Treatment of Biliary Atresia

Разумовский

Ratnikov

2018

jour

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The review of literature deals with the current classification of the biliary atresia, presents the authors’ opinion considering a technique of theKasaiprocedure, and displays modern modifications of portoenteroanastomosis estimating their effectiveness. PubMed database and Google Scholar search system were used to search for primary terms. Survival of children with this pathology was analyzed depending on theKasaitechnique, anatomical form, terms of portoenteroanastomosis and importance of early diagnosis of this pathology.

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Section: диагностикаunclassified

Modern Approaches to the Surgical Treatment of Biliary Atresia

Разумовский

Ratnikov

2018

jour

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“…The PCK7 was the only studied parameter associated with 1-year native liver survival, independently of age and fibrosis score. In a Japanese study, Obayashi et al [ 88 ] reviewed 32 biliary atresia patients undergoing hepatoportoenterostomy operation from 1976 to 2016 with more than five portal canals in biopsy samples. These authors confirmed our original study with relevance of BD/PT ratio [ 8 , 88 ].…”

Section: Treatmentmentioning

confidence: 99%

“…In a Japanese study, Obayashi et al [ 88 ] reviewed 32 biliary atresia patients undergoing hepatoportoenterostomy operation from 1976 to 2016 with more than five portal canals in biopsy samples. These authors confirmed our original study with relevance of BD/PT ratio [ 8 , 88 ]. Obayashi et al The study [ 8 , 88 ] suggests that the mean BDP ratio, i.e., the number of the bile ducts in portal canal ratio may be a better short-term prognostic indicator than PCK7.…”

Section: Treatmentmentioning

confidence: 99%

Biliary Atresia: A Complex Hepatobiliary Disease with Variable Gene Involvement, Diagnostic Procedures, and Prognosis

Sergi

Gilmour

2022

Diagnostics

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The diagnosis of biliary atresia is still terrifying at the 3rd decade of the 21st century. In a department of neonatal intensive care unit, parents and physicians face a challenge with a jaundiced baby, who may or may not have a surgically correctable hepatopathy. The approach has been systematically evaluated, but the etiology remains ambiguous. The study of families with recurrent biliary atresia has been undertaken at a molecular level. The primary interest with this disease is to identify the etiology and change the treatment from symptomatic to curative. The occurrence of this obstructive cholangio-hepatopathy in well-known genetic syndromes has suggested just coincidental finding, but the reality can be more intriguing because some of these diseases may have some interaction with the development of the intrahepatic biliary system. Several genes have been investigated thoroughly, including ADD3 and GPC1 shifting the interest from viruses to genetics. In this review, the intriguing complexities of this hepatobiliary disease are highlighted.

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“…The diagnosis and treatment of BA should not be delayed since its prognosis depends on timely and effective treatment 4 . Roux-en-Y hepatic portoenterostomy or Kasai procedure is the technique of choice as a palliative treatment 5,6 . The age at which this surgery is performed is the most important prognostic factor for survival; for example, it is estimated that 60% of cases intervened within the first 90 days of extrauterine life will restore bile flow.…”

Section: Introductionmentioning

confidence: 99%

Stool color card use for early detection of biliary atresia

Reyes-Cerecedo¹,

Flores-Calderón²,

Villasís‐Keever³

et al. 2023

BMHIME

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Background: Biliary atresia (BA) is a condition that obstructs biliary flow. If it is not corrected surgically, it can cause cirrhosis and death before 2 years of age. In Mexico, since 2013, the stool color card (SCC) was incorporated into the National Health Card (NHC) for the screening of BA. This study aimed to evaluate the impact of SCC for the detection of BA before and after its incorporation to the NHC. Methods: This is an ambispective, analytical observational study. We included patients with BA treated in two pediatric specialized hospitals. We compared the age of reference, diagnosis, and surgery before and after incorporation of the SCC. Furthermore, a questionnaire was made for the parents to know their perception about the SCC. Results: In 59 children, there was no difference among the time of diagnosis (75 vs. 70 days of life) or at the time of the surgery (84 vs. 90 days of life) between the pre-and post-implementation of the SCC on the NHC. The questionnaire showed that 10 (30%) of the parents received information about the use of the SCC and only 13 (38%) identified the abnormal stool. Conclusions: This study did not show changes in time for the timely detection of BA using SCC. Therefore, it is necessary to reinforce the program in the three levels of care in our country.

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Prognostic factors indicating survival with native liver after Kasai procedure for biliary atresia

Abstract: The BDP ratio is a better prognostic indicator than PCK7 in BA.

Cited by 13 publications

References 18 publications

Modern Approaches to the Surgical Treatment of Biliary Atresia

Modern Approaches to the Surgical Treatment of Biliary Atresia

Biliary Atresia: A Complex Hepatobiliary Disease with Variable Gene Involvement, Diagnostic Procedures, and Prognosis

Stool color card use for early detection of biliary atresia

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