Prognostic factors of hemorrhagic complications after oxaliplatin-based hyperthermic intraperitoneal chemotherapy: Toward routine preoperative dosage of Von Willebrand factor?

Delhorme, Jean-Baptiste; Sattler, Laurent; Séverac, François; Triki, E.; Groß, Isabelle; Romain, B.; Rohr, S.; Grunebaum, Lélia; Brigand, Cécile

doi:10.1016/j.ejso.2017.01.015

Cited by 10 publications

(24 citation statements)

References 30 publications

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“…Fifteen studies with a total of 1,445 patients were included in the qualitative synthesis presented in ►Table 1. 15,24,[35][36][37][38][39][40][41][42][43][44][45][46][47]…”

Section: Resultsmentioning

confidence: 99%

“…15,24,[35][36][37][38][39][40][41][42][43][44][45][46][47] Out of 15 studies, 13 studies reported primary tumor location (93%). 15,24,[35][36][37][38][39][40][41][42][43][44][45][46] Neoadjuvant chemotherapy was administered in two studies. 7,24…”

Section: Study Characteristicsmentioning

confidence: 99%

“…15,24,[36][37][38][39]41,[43][44][45] Length of surgery was reported from 240 to 1,080 minutes in 13 studies. 15,24,[35][36][37][38][39]41,[43][44][45][46][47] The HIPEC method was reported in 13 out of 15 studies. 15,24,35,36,[38][39][40][41][43][44][45][46][47] Six studies used the open abdomen method, 24,35,[38][39][40]44,45 four used the closed abdomen method, 41,43,46,47 and two used both methods for HIPEC.…”

Section: Perioperative Datamentioning

confidence: 99%

“…15,24,[35][36][37][38][39]41,[43][44][45][46][47] The HIPEC method was reported in 13 out of 15 studies. 15,24,35,36,[38][39][40][41][43][44][45][46][47] Six studies used the open abdomen method, 24,35,[38][39][40]44,45 four used the closed abdomen method, 41,43,46,47 and two used both methods for HIPEC. 15,36 Intraperitoneal chemotherapy solutions were reported in 13 of 15 studies, 15,24,35,36,[38][39][40][41][43][44][45]…”

Section: Perioperative Datamentioning

confidence: 99%

“…15,24,35,36,[38][39][40][41][43][44][45][46][47] Six studies used the open abdomen method, 24,35,[38][39][40]44,45 four used the closed abdomen method, 41,43,46,47 and two used both methods for HIPEC. 15,36 Intraperitoneal chemotherapy solutions were reported in 13 of 15 studies, 15,24,35,36,[38][39][40][41][43][44][45][46][47] with oxaliplatin utilized in four studies 15,24,39,41 and mitomycin-c in eight studies. 15,24,36,40,[43][44][45]…”

Section: Perioperative Datamentioning

confidence: 99%

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Changes in Coagulation in Cancer Patients Undergoing Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy Treatment (HIPEC)—A Systematic Review

Lundbech

Damsbo

Krag

et al. 2023

Semin Thromb Hemost

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Venous thromboembolism and postoperative bleeding are complications of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). The aim of this systematic review was to summarize current knowledge on the effect of cytoreductive surgery with HIPEC on coagulation and fibrinolysis within 10 days after surgery. Studies were identified in PubMed, Embase, and Web of Science on December 12, 2022. Data on biomarkers of coagulation and fibrinolysis measured preoperatively up to the 10th postoperative day were extracted. Among 15 included studies, 13 studies reported markers of primary hemostasis. Eleven studies found reduced platelet count following cytoreductive surgery with HIPEC and two studies reported reduced platelet function. Twelve studies reported impaired secondary hemostasis until postoperative day 10 indicated by prolonged international normalized ratio, prothrombin time, and activated partial thromboplastin time. Fibrinogen was decreased in three studies from preoperative to postoperative day 3 switching to increased levels until postoperative day 10. In accordance, three studies found reduced maximum amplitude and maximum clot firmness by thromboelastography/thromboelastometry (ROTEM/TEG) on the first postoperative day indicating impaired clot strength. Four studies demonstrated increased d-dimer, factor (F) VIII, and thrombin generation during the 10 postoperative days. Four studies investigated fibrinolysis by ROTEM/TEG and plasminogen activator inhibitor-1 (PAI-1) after cytoreductive surgery with HIPEC reporting contradictive results. In conclusion, a decrease in platelet count and subtle changes in secondary hemostasis were found following cytoreductive surgery with HIPEC. Data on the effect of cytoreductive surgery with HIPEC on fibrinolysis are sparse and this needs to be further investigated.

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“…Fifteen studies with a total of 1,445 patients were included in the qualitative synthesis presented in ►Table 1. 15,24,[35][36][37][38][39][40][41][42][43][44][45][46][47]…”

Section: Resultsmentioning

confidence: 99%