Prognostic factors of intraperitoneal chemotherapy for peritoneal carcinomatosis of gastric cancer: A retrospective study from a single center

Men, Hai-Tao; Gou, Hongfeng; Liu, Jiyan; Qiu, Li; Luo, Dan; Bi, Feng; Meng, Qingcai

doi:10.3892/ol.2016.4403

Cited by 3 publications

(5 citation statements)

References 34 publications

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“…Patient series in ovarian and gastric cancer show that ascites was associated with advanced disease stage. 17,18 In our cohort, the presence of ascites was also associated with an increased PCI. However, CRC patients with ascites who underwent CRS/HIPEC did not have worse DFS or OS compared with patients without ascites.…”

Section: Discussionmentioning

confidence: 57%

In Patients Undergoing CRS/HIPEC for Colorectal Adenocarcinoma with Peritoneal Metastases, Presence of Ascites on Computed Tomography Imaging is not a Prognostic Marker for Survival

et al. 2022

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Background Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a potentially curative treatment for patients with colorectal peritoneal metastases (CRPM). Patient selection is key to optimizing outcomes after CRS/HIPEC. The aim of this study was to determine the prognostic value of ascites diagnosed on preoperative imaging. Methods A prospective database of patients eligible for CRS/HIPEC between 2010 and 2020 was retrospectively analyzed. The presence of ascites, postoperative complications, overall survival (OS), disease-free survival (DFS), and completeness of cytoreduction were assessed. Univariable and multivariable logistic regression was performed to identify independent predictors for outcome. Results Of the 235 included patients, 177 (75%) underwent CRS/HIPEC while 58 (25%) were not eligible for CRS/HIPEC. In 42 of the 177 patients (24%) who underwent CRS/HIPEC, ascites was present on preoperative computed tomography (CT) imaging. Peritoneal Cancer Index (PCI) score was significantly higher in patients with preoperative ascites compared with patients without (11 [range 2–30] vs. 9 [range 0–28], respectively; p = 0.011) and complete cytoreduction was more often achieved in patients without ascites (96.3% vs. 85.7%; p = 0.007). There was no significant difference in median DFS and OS after CRS/HIPEC between patients with and without ascites {10 months (95% confidence interval [CI] 7.1–12.9) vs. 9 months (95% CI 7.2–10.8), and 25 months (95% 9.4–40.6) vs. 27 months (95% CI 22.4–31.6), respectively}. Conclusions Ascites on preoperative imaging was not associated with worse survival in CRS/HIPEC patients with CRPM. Therefore, excluding patients from CRS/HIPEC based merely on the presence of ascites is not advisable.

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Section: Discussionmentioning

confidence: 57%

In Patients Undergoing CRS/HIPEC for Colorectal Adenocarcinoma with Peritoneal Metastases, Presence of Ascites on Computed Tomography Imaging is not a Prognostic Marker for Survival

et al. 2022

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“…Chemotherapy is less effective than other histologies and has a shorter survival rate [77]. Cytoreductive surgery, intraoperative hyperthermic intraperitoneal chemotherapy (CRS+HIPEC), and low-dose pressurised intraperitoneal aerosol chemotherapy (PIPAC) are techniques which are still under investigation but can be used; however, they should be restricted to highly selective patients [49,102,103].…”

Section: Discussionmentioning

confidence: 99%

“…Compared to other histotypes, SRCC tumours had better survival in the early stages (RR = 0.67, 95% CI 0.38-0.97) a similar survival in the advanced stages (RR = 1.15, 95% CI 0.94-1.36), and worse surviva in metastatic cancers (RR = 1.29, 95% CI 1.09-1.49). [69]; Alshehri A (2020) [47]; Benesch MGK (2020) [89]; Charalampakis N (2016) [86]; Cho JH (2015) [48]; Chon HJ (2017) [65]; de Aguiar VG (2019) [93]; Dong X (2021) [72]; Gronnier C (2013) [76]; Guo CG (2015) [29]; Heger U (2014) [8]; Hsu JT (2016) [60]; Imamura T (2016) [34]; Jiang CG (2011) [53]; Kao YC (2019) [68]; Khan N (2020) [82]; Lemoine N (2016) [77]; Liu X (2015) [59]; Lu M (2016) [62]; Luu C (2017) [88]; Men HT (2016) [49]; Piessen G (2012) [79]; Postlewait LM (2015) [85]; Riihimäki M (2016) [78]; Schmidt T (2014) [69]; Alshehri A (2020) [47]; Benesch MGK (2020) [89]; Charalampakis N (2016) [86]; Cho JH (2015) [48]; Chon HJ (2017) [65]; de Aguiar VG (2019) [93]; Dong X (2021) [72]; Gronnier C (2013) [76]; Guo CG (2015) [29];…”

Section: Lymphovascular Invasionmentioning

confidence: 99%

“…Heger U (2014) [8]; Hsu JT (2016) [60]; Imamura T (2016) [34]; Jiang CG (2011) [53]; Kao YC (2019) [68]; Khan N (2020) [82]; Lemoine N (2016) [77]; Liu X (2015) [59]; Lu M (2016) [62]; Luu C (2017) [88]; Men HT (2016) [49]; Piessen G (2012) [79]; Postlewait LM (2015) [85]; Riihimäki M (2016) [78]; Schmidt T (2014) [80]; Shim JH (2014) [58]; Shridhar R (2013) [83]; Taghavi S (2012) [84]; Tang CT (2020) [90]; Voron T (2016) [81]; Wang Z (2015) [32]; Zhao X (2021) [92]; Zu H (2014) [46].…”

Section: Lymphovascular Invasionmentioning

confidence: 99%

“…The red diamond expresses the group-specific effect size, and the green diamond represents the global effect size. References: Ahn H (2020)[69]; Alshehri A (2020)[47]; Benesch MGK (2020)[89]; Charalampakis N (2016)[86]; Cho JH (2015)[48]; Chon HJ (2017)[65]; de Aguiar VG (2019)[93]; Dong X (2021)[72]; Gronnier C (2013)[76]; Guo CG (2015)[29]; Heger U (2014)[8]; Hsu JT (2016)[60]; Imamura T (2016)[34]; Jiang CG (2011)[53]; Kao YC (2019)[68]; Khan N (2020)[82]; Lemoine N (2016)[77]; Liu X (2015)[59]; Lu M (2016)[62]; Luu C (2017)[88]; Men HT (2016)[49]; Piessen G (2012)[79]; Postlewait LM (2015)[85]; Riihimäki M (2016)[78]; Schmidt T (2014)…”

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confidence: 99%

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Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-Analysis

Dal Cero,

Bencivenga,

Liu

et al. 2023

Cancers

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Background: Conflicting results about the prognostic relevance of signet ring cell histology in gastric cancer have been reported. We aimed to perform a meta-analysis focusing on the clinicopathological features and prognosis of this subgroup of cancer compared with other histologies. Methods: A systematic literature search in the PubMed database was conducted, including all publications up to 1 October 2021. A meta-analysis comparing the results of the studies was performed. Results: A total of 2062 studies referring to gastric cancer with signet ring cell histology were identified, of which 262 studies reported on its relationship with clinical information. Of these, 74 were suitable to be included in the meta-analysis. A slightly lower risk of developing nodal metastases in signet ring cell tumours compared to other histotypes was found (especially to undifferentiated/poorly differentiated/mucinous and mixed histotypes); the lower risk was more evident in early and slightly increased in advanced gastric cancer. Survival tended to be better in early stage signet ring cell cancer compared to other histotypes; no differences were shown in advanced stages, and survival was poorer in metastatic patients. In the subgroup analysis, survival in signet ring cell cancer was slightly worse compared to non-signet ring cell cancer and differentiated/well-to-moderately differentiated adenocarcinoma. Conclusions: Most of the conflicting results in signet ring cell gastric cancer literature could be derived from the lack of standardisation in their classification and the comparison with the different subtypes of gastric cancer. There is a critical need to strive for a standardised classification system for gastric cancer, fostering clarity and coherence in the forthcoming research and clinical applications.

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Analysis of the treatment efficacy and prognostic factors of PD-1/PD-L1 inhibitors for advanced gastric or gastroesophageal junction cancer: a multicenter, retrospective clinical study

Yang,

Wang,

Xin

et al. 2024

Front. Immunol.

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IntroductionImmune checkpoint inhibitors (ICIs) have transformed advanced gastric cancer treatment, yet patient responses vary, highlighting the need for effective biomarkers. Common markers, such as programmed cell death ligand-1 (PD-L1), microsatellite instability/mismatch repair (MSI/MMR), tumor mutational burden, tumor-infiltrating lymphocytes, and Epstein–Barr virus, face sampling challenges and high costs. This study seeks practical, minimally invasive biomarkers to enhance patient selection and improve outcomes.MethodsThis multicenter retrospective study analyzed 617 patients with advanced gastric or gastroesophageal junction cancer treated with programmed cell death protein-1 (PD-1)/PD-L1 inhibitors from January 2019 to March 2023. Clinical data and peripheral blood marker data were collected before and after treatment. The primary endpoints were overall survival (OS) and progression-free survival (PFS); the secondary endpoints included the objective response rate (ORR) and disease control rate (DCR). Least absolute shrinkage and selection operator (LASSO)-Cox and LASSO logistic regression analyses identified independent factors for OS, PFS, and ORR. Predictive nomograms were validated using receiver operating characteristic (ROC) curves, areas under the curve (AUCs), C-indices, and calibration curves, with clinical utility assessed via decision curve analysis (DCA), net reclassification improvement (NRI), and integrated discrimination improvement (IDI).ResultsOS-related factors included treatment line, T stage, ascites, pretreatment indirect bilirubin (pre-IBIL), posttreatment CA125, CA199, CA724, and the PLR. PFS-related factors included treatment lines, T stage, metastatic sites, pre-IBIL, posttreatment globulin (GLOB), CA125, and CA199 changes. ORR-related factors included treatment line, T stage, N stage, liver metastasis, pretreatment red cell distribution width-to-platelet ratio (RPR), CA125, and CA724 changes. The nomograms showed strong predictive performance and clinical utility.ConclusionsEarly treatment, lower T stage, the absence of ascites, and lower pre-IBIL, post-CA125, CA199, CA724, and PLR correlate with better OS. Factors for improved PFS include early treatment, lower T stage, fewer metastatic sites, and lower pre-IBIL, post-GLOB, and post-CA125 levels. Nomogram models can help identify patients who may benefit from immunotherapy, providing valuable clinical guidance.

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Prognostic factors of intraperitoneal chemotherapy for peritoneal carcinomatosis of gastric cancer: A retrospective study from a single center

Cited by 3 publications

References 34 publications

In Patients Undergoing CRS/HIPEC for Colorectal Adenocarcinoma with Peritoneal Metastases, Presence of Ascites on Computed Tomography Imaging is not a Prognostic Marker for Survival

In Patients Undergoing CRS/HIPEC for Colorectal Adenocarcinoma with Peritoneal Metastases, Presence of Ascites on Computed Tomography Imaging is not a Prognostic Marker for Survival

Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-Analysis

Analysis of the treatment efficacy and prognostic factors of PD-1/PD-L1 inhibitors for advanced gastric or gastroesophageal junction cancer: a multicenter, retrospective clinical study

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