Prognostic Factors of Primary Intraosseous Squamous Cell Carcinoma (PIOSCC): A Retrospective Review

Abstract

ObjectivesTo delineate clinical and pathological features and determine the prognostic factors of primary intraosseous squamous cell carcinoma (PIOSCC).Materials and methodsPatients diagnosed with PIOSCC, attending the department of oral and maxillofacial surgery, Nanjing stomatological hospital between 2005 and 2015, were identified and retrospectively reviewed for clinical and pathological characteristics. Therapeutic modalities were measured and related follow-up data recorded, in order to determine prognostic factors of PIOSSC.ResultsA total of 77 patients with PIOSCC were included in the study. Mean age at diagnosis was 58.8 years, (range, 37−81 years). Of the 77 patients, there were 58 men and 19 women. The most common location of disease was the mandible (71.42%), particularly the posterior mandible. The common presenting symptoms included jaw swelling (79.2%) and ulceration (42.65%). The estimated 2-year and 5-year overall survival were 68.9% and 38.8%, respectively. Univariate analysis identified the following as negative prognostic factors: histological grade, N classification, nodal status and treatment modalities. However, multivariate analysis determined positive nodal status, high histological grade and advanced N classification as the independent significant prognostic factors.ConclusionOur results demonstrate several clinical and pathological features of PIOSCC and identify important prognostic factors associated with overall survival in PIOSCC. These prognostic factors include nodal status, histological grade, N classification, and treatment modalities, all of which are important for patient counseling and may be useful for the development of new treatment approaches.

Metformin sensitizes the response of oral squamous cell carcinoma to cisplatin treatment through inhibition of NF-κB/HIF-1α signal axis

“…According to the protocol of treatment guidelines for oral cancers, chemotherapy would be recommended for patients with loco-regionally advanced diseases especially if aggressive features were found, such as positive surgical margins and extracapsular spread in lymph node metastasis 7 . Currently, cisplatin-based chemotherapeutic regimens have been the most widely and frequently used adjuvant treatments against OSCC 8 ; however, chemotherapeutic drugs do not specifically target tumour cells, and thus may have deleterious effects on normal cells. In addition to this, chemotherapy resistance tends to develop as the treatment continues, which is the main cause of tumour relapse and treatment failure 9 .…”

Primary intraosseous carcinoma, NOS in a 17‐year‐old male: case report and literature review

“…Similarly, Wenguang et al retrospectively reviewed all types of PIOC in their 2015 study and found 2-and 5-year survival rates of 68.9% and 38.8% respectively 13 . Furthermore, by univariant and multivariant analysis, they determined adverse prognostic factors to include: advance nodal classification, high histologic grade and positive nodal status 13 . In the cases reviewed here, the patients were disease free at variable follow-up periods, but long-term follow-up is not known.…”

“…PIOC has a predilection for males, with a male: female ratio of 2:1, which may be attributed to the higher incidence of odontogenic cysts in males 1,2 . Differential diagnoses for PIOC include, but are not limited to: maxillary sinus neoplasm, alveolar mucosal or gingival carcinoma that has invaded bone, odontogenic tumour or metastasis from a primary tumour elsewhere 13,14 . Elimination of these conditions often delays diagnosis.…”

“…Differential diagnoses for PIOC include, but are not limited to: maxillary sinus neoplasm, alveolar mucosal or gingival carcinoma that has invaded bone, odontogenic tumour or metastasis from a primary tumour elsewhere. Elimination of these conditions often delays diagnosis.…”

Solid type primary intraosseous squamous cell carcinoma in a cat

“…The histopathological findings were consistent with oral SCC in cats [ 17 ] and SCC [ 18 ] and solid type PIOSCC in humans [ 6 ]. Given the clinicopathological features in this cat, and since prominent features including cellular atypia, moderate mitotic activity and no true keratinization were observed in the sections examined; this tumor was further classified as a poorly differentiated nonkeratinizing solid type PIOSCC [ 13 , 19 , 20 ].…”