Prognostic factors of primary resected retroperitoneal soft tissue sarcoma: Analysis from a single asian tertiary center and external validation of gronchi's nomogram

Abstract

Our study demonstrated tumor grade and surgical margins had significant prognostic influence and the Gronchi's nomogram has an excellent applicability in predicting survival of STS patients. J. Surg. Oncol. 2016;113:355-360. © 2016 Wiley Periodicals, Inc.

Soft tissue sarcoma nomograms and their incorporation into practice

“…In this context, instruments such as nomograms are useful to physicians for prognostication; thus a prognostic nomogram for RPS was included in the last version of the AJCC staging system. Available nomograms specific for RPS are detailed in Table …”

“… External validations were performed on 135 patients from Institut Gustave Roussy in Villejuif, France (Harrell C‐index of 0.67 for the OS nomogram and 0.68 for the DFS nomogram); 631 patients from a multicentric cohort of the Trans‐Atlantic Retroperitoneal Sarcoma Working Group (Harrell C‐index of 0.73 for the OS nomogram and 0.69 for the DFS nomogram); and 144 patients from Taipei Veterans General Hospital in Taipei, Taiwan (Harrell C‐index, 0.72 for the OS nomogram) …”

Prognostic models for RPS patients—Attempting to predict patient outcomes

“…Importantly, these models underwent three independent external validations including: single institutional series from Institut Gustave Roussy, Paris, France, a multicentric series from the Trans‐Atlantic Retroperitoneal Sarcoma Working Group (TARPSWG) and a series from Taipei Veterans General Hospital, Taipei, Taiwan . Both nomograms proved to be well calibrated and to maintain a good discriminative ability when applied to external cohorts (Harrell C index ranging from 0.67 to 0.73) as a proof of their broad applicability.…”

Management of the “Other” retroperitoneal sarcomas

“…The histologies of SFT, MPNST, and UPS have been included in prognostic analyses and nomograms for primary, resectable retroperitoneal soft tissue sarcomas. These studies have clearly shown that grade and histology‐specific subtype are two very important predictive covariates for overall and disease‐free survival . A striking example is that a low‐grade SFT has a lower long‐term risk of death than does a well‐differentiated liposarcoma (which by definition is also a low‐grade retroperitoneal sarcoma).…”

“…These studies have clearly shown that grade and histology-specific subtype are two very important predictive covariates for overall and disease-free survival. 1,[4][5][6]8,10,11 A striking example is that a low-grade SFT has a lower long-term risk of death than does a well-differentiated liposarcoma…”