Prognostic factors of recurrent respiratory papillomatosis from a registry of 72 patients

Abstract

Data on 72 patients were entered into an RRP database between January 2005 and July 2007. In all, 82% had already been treated for RRP in a different centre; 24 had juvenile-onset (JORRP) and 48 adult-onset (AORRP) papillomatosis. Cidovir injections had been administered to 91% of the patients. Histology found nine cases of dysplasia, one of carcinoma in situ and one of invasive carcinoma. Subglottic and tracheal locations were significantly more frequent in JORRP than in AORRP, as were the maximum Derkay scores and annual numbers of endoscopies. Patients with type 11 HPV had significantly more endoscopies per year than those with type 6.

Age of diagnosis, incidence and prevalence of recurrent respiratory papillomatosis—A South African perspective

“…We found that 53 (57.6%) patients had HPV6 disease and 39 (42.4%) patients HPV11 disease. The proportion of HPV11 infection in our study was slightly higher than that in previous studies where HPV11 was identified in between 8% and 39.8% of papillomas …”

Clinical features, health‐related quality of life, and adult voice in juvenile‐onset recurrent respiratory papillomatosis

“…Four patients (22%) in this series had undergone tracheotomy, more than the reported 0% to 10% of JORRP patients 16–18. These four tracheotomies were performed before sophisticated techniques such as the CO 2 laser became the standard of care.…”

The role of HPV type in Recurrent Respiratory Papillomatosis

“…Overall if HPV11 produces more aggressive disease than HPV6 the former type should be more prevalent in children (as RRP is more aggressive in children). Indeed, this HPV prevalence is implied in published data [59], [60]. Both low and high-risk HPVs are known to be associated with malignancy although high-risk types are considerably more likely to result in transformation, hence the nomenclature, ''high risk.''…”