Prognostic Factors of Squamous Cell Carcinoma of the Buccal Mucosa: A Retrospective Study of 168 Cases in North China

Niu, Li; Feng, Zhien; Li, Jian Nan; Li, Chuan Zhen; Peng, Xin

doi:10.1016/j.joms.2014.05.021

Cited by 31 publications

(18 citation statements)

References 17 publications

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“…In the present study, we found that the presence of high-grade histology was strongly associated with advanced T stage, neck lymph node metastasis, and extranodal spread, which subsequently contributed to advanced stage and prevalent recurrence. Similar conclusions have been deduced in previous research [12][13][14][15][16][17][18]. Kademani et al presented 10-year survival among three different histological grade OSCCs in 233 patients, and their results were similar to those of our study [12].…”

Section: Discussionsupporting

confidence: 93%

Survival and clinicopathological characteristics of different histological grades of oral cavity squamous cell carcinoma: A single-center retrospective study

2020

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The TNM staging system for oral squamous cell carcinoma (OSCC) provides clinicians a dependable foundation for patient prognosis and management decisions, but in clinical practice, treatment outcomes of patients with OSCC are sometimes unsatisfactory. This retrospective study investigated the association between survival and clinicopathological characteristics and histological grades of 2535 patients with OSCC. Additionally, the present study aimed to compare the predictive abilities of histological grades with other common prognostic factors. The enrolled patients were divided into three groups by two experienced pathologists into well-differentiated, moderately differentiated, and poorly differentiated groups, according to the WHO classification. Finally, we designed an observational, retrospective study based on the histological grading of tumors to compare their clinicopathological characteristics and conducted survival analysis among the three groups. Advanced tumor stage was diagnosed in 23.9%, 44.0%, and 55.1% of patients with grades 1-3 OSCC, respectively. By T status, T3 or T4 tumors were found in approximately 22%, 34%, and 40% of patients with grades 1-3 OSCC, respectively. By N status, lymph node metastases were found in 6.1%, 29.3%, and 45.9% of patients with grades 1-3 OSCC, respectively. Thus, significant survival differences were observed based on different OSCC histological grades. Meanwhile, in the multivariate (adjusted) analysis, N1 and N2 stages, extranodal spread, and poor differentiation were associated with a higher recurrence risk than the other common prognostic factors. In conclusion, 5% of patients in our study presented with poorly differentiated OSCC at diagnosis. Furthermore, grade 3 OSCC has worse prognosis and is more aggressive than grades 1 and 2 OSCC. In the future, we should focus on modifying individual therapy for poorly differentiated OSCC to achieve improved outcomes.

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Section: Discussionsupporting

confidence: 93%

Survival and clinicopathological characteristics of different histological grades of oral cavity squamous cell carcinoma: A single-center retrospective study

2020

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“…In this study, the pathologic grade was also evaluated by this method. However, the conventional classification is suggested by many authors that it cannot predict the prognosis of OSCC independently; furthermore, similar results were observed in our previous studies (Feng et al., ; Niu et al., ). Therefore, new methods about pathologic grade were recently proposed, and studies regarding the feasibility of these methods were also performed.…”

Section: Introductionsupporting

confidence: 90%

Prognostic value of pathologic grade for patients with oral squamous cell carcinoma

Wang

et al. 2017

Oral Diseases

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“…Previously, due to the lack of sufficient examinations and the limits of the techniques used, a diagnosis of negative neck was relatively unreliable. However, studies of squamous cell carcinoma of the oral cavity conducted by the same hospital during a similar period illustrated that the occult metastasis was lower than in OPSCC, 29 , 30 which also indicated the aggressiveness of OPSCC. Currently, with the help of multiple examination techniques, the sensitivity and specificity of cervical nodal metastasis identification have sharply increased; yet, occult metastases still occur, indicating the necessity of thorough examinations and care in neck dissection decisions, regardless of tumor stage.…”

Section: Discussionmentioning

confidence: 93%

Retrospective study of survival in human papillomavirus-negative oropharyngeal squamous cell carcinoma treated with primary surgery and associated prognostic factors

Yuan

Wang

et al. 2018

OTT

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BackgroundOropharyngeal squamous cell carcinoma (OPSCC) is an aggressive malignancy which has been investigated for decades and reported highly associated with the human papillomavirus (HPV) infection, yet there is no consensus reached on the optimal treatment paradigm. The relatively lower prevalence of HPV in China makes it important to evaluate the outcomes of HPV-negative OPSCC.PurposeOur study was carried out in an attempt to evaluate the outcomes of squamous cell carcinoma of the oropharynx treated with primary surgery and identify the associated prognostic factors.Patients and methodsWe retrospectively analyzed the outcomes of the primary surgically treated HPV-negative OPSCC cases at our institution between 2008 and 2013. Overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were determined by Kaplan–Meier analysis. Prognostic factors of outcomes were investigated by uni- and multivariate analyses.ResultsIn this study, neck metastasis rate was 61.3%. Level II nodes were the most vulnerable. The 3-year disease-specific survival, overall survival, and disease-free survival rates were 76.7%, 75.6%, and 62.8%, respectively. Forearm free flaps were the most commonly utilized in the reconstructions. A multivariate analysis indicated that N stage and adjuvant radiotherapy were predictive factors for 3-year disease-specific survival.ConclusionThe outcomes of the surgical treatment of oropharyngeal squamous cell carcinoma were acceptable, and N-stage, adjuvant radiotherapy were identified as prognostic factors.

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Prognostic Factors of Squamous Cell Carcinoma of the Buccal Mucosa: A Retrospective Study of 168 Cases in North China

Cited by 31 publications

References 17 publications

Survival and clinicopathological characteristics of different histological grades of oral cavity squamous cell carcinoma: A single-center retrospective study

Survival and clinicopathological characteristics of different histological grades of oral cavity squamous cell carcinoma: A single-center retrospective study

Prognostic value of pathologic grade for patients with oral squamous cell carcinoma

Retrospective study of survival in human papillomavirus-negative oropharyngeal squamous cell carcinoma treated with primary surgery and associated prognostic factors

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