Prognostic Factors of Vision in Patients with Behcet Disease

Sakamoto, Maki; Akazawa, Kouhei; Nishioka, Yuko; Sanui, H; Inomata, Hajime; Nosé, Yukihiko

doi:10.1016/s0161-6420(95)31022-6

Cited by 82 publications

(46 citation statements)

References 8 publications

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“…This rate was higher than what was found in other literature. [11,[22][23][24] In our study, it was shown that women have a more favorable prognosis than men. This could be related to the higher frequency and preponderance of severe inflammation (retinitis and vasculitis) in men.…”

Section: Discussionmentioning

confidence: 50%

Behçet’s Disease: The Clinical and Demographic Characteristics of 406 Patients

et al. 2012

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Amaç: Bu çalışmada Behçet hastalığı olan kişilerde hastalığın demografik ve klinik özellikleri, prognostik faktörleri, oküler ve sistemik bulgularının tanımlanması ve araştırılması amaçlandı. Hastalar ve yöntemler: Çalışmaya Uluslararası BehçetHastalığı Çalışma Grubu'nun sınıflama kriterlerini karşılayan 406 hasta (306 erkek, 100 kadın; ort. yaş 36.1; dağılım 12-76) dahil edildi. Başlangıç yaşı, cinsiyet, oküler tutulum tipi, görme keskinliği, sistemik bulgular ve başlangıç bulguları dahil olmak üzere klinik ve demografik özellikler ve tedavi yöntemleri gözden geçirildi. Bulgular:Ortalama başlangıç yaşı erkeklerde 27.6±7.2 yıl, kadınlarda ise 29.0±9.3 yıl idi. Oküler tutulum sıklığı (erkeklerde %68.9, kadınlarda %65; p=0.163) ve her iki gözde tutulum sıklığı (erkeklerde %56.2, kadınlarda %53.0; p=0.67) açısından, her iki cinsiyet arasında anlamlı fark yoktu. Hastalığın en sık görülen ilk başlangıç bulgusu %71.9 ile oral aftöz ülser iken, bunu %23.4 ile oküler tutulum izliyordu. Başlıca klinik bulgu oral aftöz ülser iken (%100), bunu genital ülser (%82.8) ve oküler tutulum (%80.3) izliyordu. HLA-B51, 372 hastanın 170'inde pozitifti (%45.7). HLA-B51 pozitifliğinin oküler inflamatuvar atakların sıklığı ve ciddiyeti üzerinde bir etkisi yoktu. Üç yüz altı erkeğin 141'inde (%46.1) ve 100 kadının 29'unda (%29.0) ağır oküler atak mevcut olup, erkeklerin %34.6'sında (n=106) ve kadınların %21'inde (n=21) sık oküler tutulum izlendi. Erkeklerdeki ataklar, kadınlarınkine göre daha sık (p=0.03) ve daha ağırdı (p=0.015). Siklosporin A, sık atak geçirenlerde en sık tercih edilen ilaçtı (%24.3; p=0.019).Sonuç: Behçet hastalığında oküler tutulum erkeklerde anlamlı olarak daha sık ve ağır seyreder. Görme keskinliğini etkileyen başlıca prognostik kriter, oküler tutulumun sıklığı ve şiddetidir.Anahtar sözcükler: Behçet hastalığı; HLA-B51; inflamatuvar atak; üveit; görme prognozu. Objectives:In this study, we aim to describe and investigate the demographic and clinical features, prognostic factors, ocular, and systemic manifestations of the patients with Behçet's Disease. Patients and methods:The study included 406 patients (306 males, 100 females; 36.1 years; range 12 to 76 years) who met the classification criteria of the International Study Group for Behçet's Disease. The clinical and demographic characteristics including age at onset, sex, type of ocular involvement, visual acuity, systemic manifestations, and initial signs, and treatment modalities were reviewed. Results:The mean age at onset was 27.6±7.2 years in male patients and 29.0±9.3 years in females. There were no significant differences between both sex in terms of the frequency of ocular involvement (68.9% in male, 65.0% in female, p=0.163) and bilaterality of the ocular involvement (56.2% in male and 53.0% in female, p=0.67). The most common initial presenting manifestation of the disease was oral aphthous ulcer which was seen in 71.9% of the patients, followed by ocular involvement (23.4%). The leading clinical features were oral aphthous ulcers (100%), followed by g...

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Section: Discussionmentioning

confidence: 50%

Behçet’s Disease: The Clinical and Demographic Characteristics of 406 Patients

et al. 2012

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“…B ehçet's disease is a chronic, recurrent and multisystem inflammatory disorder characterized by orogenital ulcers, ocular and skin lesions (Sakamato et al 1995). The cause and pathogenesis of Behçet's disease remain unknown.…”

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confidence: 99%

Color Doppler ultrasonography in ocular Behçet's disease

Çelebi¹,

Akfirat²,

Çelebi

et al. 2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: The aim of this prospective study was to assess the ocular hemodynamic changes in patients with Behçet's disease who had involvement of the posterior segment by color Doppler ultrasonography. Methods: The present study was carried out in 32 eyes of 24 patients with ocular Behçet's disease and 42 eyes of 21 persons as a healthy age-matched control group. In order to detect the hemodynamic changes in ocular Behçet's disease, peak systolic and end-diastolic velocities (PSV, EDV; cm/sec), resistive and pulsatile indices (RI, PI), and PSV/EDV ratio of central retinal artery (CRA), short posterior ciliary artery (PCA) and ophthalmic artery (OA) were determined. Results: The mean PSV and EDV (8.1∫2.6 and 2.7∫0.1 cm/sec, respectively) in the CRA were significantly lower in patients with Behçet's disease than in healthy controls (11.5∫2.2 and 3.5∫1.0 cm/sec, respectively, p∞0.001). For the PCA, these values (12.7∫4.2 and 4.3∫1.1 cm/sec, respectively) were significantly lower in the patient group than in the control the group (18.2∫4.2 and 6.1∫2.5 cm/sec, respectively, p∞0.001). In the patient group, a statistically significant decrease compared to the control group was detected in the mean PSV of the OA (31.8∫8.2 and 35.8∫0.6 cm/sec, respectively, p∞0.02). However, no significant difference in the other parameters of these vessels was observed between groups.Conclusions: These results demonstrate the presence of some circulatory changes in the flow velocities of the CRA, PCA and OA in patients with Behçet's disease when compared with control subjects.

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“…Demographic data which may affect the vision loss survival curve were analyzed. The mean age at onset was 36.0 years, which is slightly older than reported for Japanese or Turkish patients [13,14,15]. The male and female proportions were 56 and 44%, respectively, which suggests a higher proportion of females than for other countries [13,14,15].…”

Section: Discussionmentioning

confidence: 73%

Visual Prognosis and Risk Factors for Korean Patients with Behcet Uveitis

et al. 2008

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Purpose: Visual prognosis was evaluated in Korean Behcet uveitis patients. The study investigated factors associated with poor visual outcome, and the effect of various treatments on recurrence-free duration. Methods: A retrospective analysis was undertaken on 99 consecutive Behcet uveitis patients (168 eyes). Visual prognosis was evaluated using Kaplan-Meier survival curves, and Cox’s proportional hazard regression analysis was used to identify risk factors. Results: Visual acuity at the first visit (<0.5), presence of vasculitis, male gender, and posterior/panuveitis type were associated with poor visual prognosis. Visual acuity at the first visit was found to be the most significant risk factor (hazard ratio = 7.392, p = 0.007). Analysis of 9 different treatment modalities showed patients treated with steroids had longer recurrence-free periods than those not treated with steroids (p = 0.0053, t test). Conclusion: Whilethe long-term visual prognosis for Behcet uveitis may be affected by many factors, the initial visual acuity appears to be the most significant. Treatments involving steroids appear to decrease the frequency of uveitis recurrence.

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Prognostic Factors of Vision in Patients with Behcet Disease

Cited by 82 publications

References 8 publications

Behçet’s Disease: The Clinical and Demographic Characteristics of 406 Patients

Behçet’s Disease: The Clinical and Demographic Characteristics of 406 Patients

Color Doppler ultrasonography in ocular Behçet's disease

Visual Prognosis and Risk Factors for Korean Patients with Behcet Uveitis

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