Prognostic factors predicting survival rate over 10 years of patients with intrahepatic cholangiocarcinoma after hepatic resection

Abstract

Hepatic resection is considered as the optimal treatment for intrahepatic cholangiocarcinoma (IHCC); however, the survival rate after resection is low and the analysis of long-term (≥10 years) survivors is rare. This study aims to analyze the clinicopathological factors affecting the long-term survival of patients with IHCC. Methods: Between January 2003 and December 2012, a single-institution cohort of 429 patients who underwent hepatic resection for IHCC were reviewed retrospectively. Surgical results, recurrence, and survival rates were investigated, and multivariate analyses were performed to identify prognostic factors. Results: The overall 1-, 3-, 5-and 10-year survival rates of patients were 76.5%, 44.1%, 33.3%, and 25.1%, respectively. Multivariate analysis showed that the serum CA 19-9 level (≥38 U/mL) (P < 0.001), lymph node (LN) metastasis (P = 0.001), and lymphovascular invasion (LVI) (P = 0.012) were independent factors associated with overall survival. In particular, CA 19-9 level and histologic type were determined to be independent factors affecting survival for more than 10 years. Conclusion: CA 19-9 (≥38 U/mL), LN metastasis, and LVI were identified as independent risk factors for survival after resection of IHCC. CA 19-9 (<38 U/mL) and histologic type were independent factors predicting survival for more than 10 years.

Repeated resection for recurrent intrahepatic cholangiocarcinoma: A retrospective German multicentre study

“…CA19‐9 has been established as the main serum tumour marker for ICC 26 . Several studies have shown the negative influence of higher CA19‐9 values on survival 27‐30 . Therefore, elevated CA19‐9 values are obviously predictive of poor tumour biology.…”

“…26 Several studies have shown the negative influence of higher CA19-9 values on survival. [27][28][29][30] Therefore, elevated CA19-9 values are obviously predictive of poor tumour biology. Precise cut-offs for better prediction may be defined in the future.…”

The role of lymph node dissection and a new N-staging system for intrahepatic cholangiocarcinoma: a study from the SEER database

“…Several factors can worsen survival, such as pathogenic factors, tumor size, tumor number, lymph node metastasis (LNM), vascular infiltration, degree of differentiation, and carbohydrate antigen (CA) 19-9 concentration, all of which are related to the ICC prognosis. [4][5][6][7][8][9] LNM is a clear risk factor and is particularly important. [4][5][6]10 Lymph node dissection (LND) is a component of ICC radical surgery.…”

Effect of liver fibrosis on survival in patients with intrahepatic cholangiocarcinoma: a SEER population-based study

“…Tumor size, stage and morphology are associated with prognosis and are all included in the American Joint Committee on Cancer (AJCC) staging system. Surgical margins, local lymph node tumor involvement and vascular or perineural invasion markedly affect survival [12,13]. While there is strong evidence to support the causative role of cirrhosis in the development of iCCA, the role of cirrhosis as a prognostic factor is debatable with contradicting findings from previous studies [14][15][16][17][18].…”