Prognostic features of carcinoma of the fallopian tube

Peters, Wolfgang J; Andersen, Willie A.; Hopkins, Matthew R.; Kumar, Naresh; Morley, George W.

doi:10.1016/0090-8258(88)90161-8

Cited by 21 publications

(33 citation statements)

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“…Despite advances in therapy, the prognosis is poor, the overall 5-year survival rate being 33-57% [3][4][5][6] . The size of the residual tumour, clinical stage, histological grade and age of the patient have been shown to affect prognosis [3,[7][8][9] .…”

Section: Odsmentioning

confidence: 99%

Preoperative Serum hCGβ as a Prognostic Marker in Primary Fallopian Tube Carcinoma

Riska¹,

Alfthan²,

Finne³

et al. 2006

Tumor Biol

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Objectives: It was the aim of this study to evaluate the prognostic value of the pretreatment serum concentrations of the β-subunit of human chorionic gonadotropin (hCGβ), CA 125 and tumour-associated trypsin inhibitor (TATI) in primary fallopian tube carcinoma (PFTC). Methods: The pretreatment serum concentrations of hCGβ, CA 125 and TATI were analyzed in serum samples from 60 women with a mean age of 61 years, treated for PFTC between 1985 and 2000. Of the 91 patients treated during this period, 31 were excluded because no serum sample was available. The patients were followed-up for recurrence and survival until February 14, 2003. The prognostic value of the serum markers were compared with those of stage, grade and histological type. Results: The median survival time was 27 months and the overall 5-year survival rate 33%. Stage and size of the residual tumour (<1 vs. ≧1 cm) predicted both overall and disease-free survival (p < 0.050). Histology (serous vs. others) (p = 0.023) also influenced overall survival. Overall 5-year survival was 38% when serum hCGβ was below 3.5 pmol/l, while it was 18% when the level was higher (p = 0.052). The corresponding disease-free 5-year survival was 38 and 20%, respectively (p = 0.014). Patients with CA 125 values above 1,017 kU/l had an overall 5-year survival of 39% as compared with 14% for those with lower values (p = 0.009), while the disease-free survival was 37 and 23%, respectively (p = 0.096). Serum TATI was not a prognostic marker. Serum concentrations of hCGβ and CA 125 correlated significantly with stage (p = 0.049 and p = 0.050, respectively). In multivariate Cox proportional hazards regression analysis, only hCGβ, stage and histology emerged as independent prognostic factors. Conclusions: Clearly elevated serum concentrations of hCGβ and CA 125 predict survival in fallopian tube carcinoma, but in multivariate analyses, only hCGβ is a prognostic factor independent of stage and histology.

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Section: Odsmentioning

confidence: 99%

Preoperative Serum hCGβ as a Prognostic Marker in Primary Fallopian Tube Carcinoma

Riska¹,

Alfthan²,

Finne³

et al. 2006

Tumor Biol

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“…Associations with pelvic inflammatory disease and tuberculous salpingitis has been reported in the literature (10,12,13) . Families with germline BRCA1 and BRCA2 mutations, as in ovarian and breast cancer, have an increased tendency for developing fallopian tube carcinoma (14)(15)(16)(17)(18)(19) .…”

Section: Discussionmentioning

confidence: 98%

An unusual case of primary fallopian tube carcinoma in pregnancy

Batra

Singh

Wynn

2006

Int J Gynecol Cancer

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Fallopian tube carcinoma is the rarest of all female genital tract malignancies. It usually occurs in postmenopausal women and is associated with infertility. We present the first reported case of it occuring as a primary tumor in a young primigravida. It presented as a large, rapidly growing adnexal mass at 9 weeks of gestation which was removed and found to be a papillary serous carcinoma of the fallopian tube. The patient continued the pregnancy to term and delivered a live healthy infant by ventouse. A staging laparotomy in the postnatal period showed no spread of tumor, and in view of her age and desire for furthur pregnancies, her uterus and other ovary and tube were conserved. She remains tumor free 2 years following detection. We discuss the incidence, progress, management, and survival rates of this rare gynecological malignancy.

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“…Staging of the disease in accordance to the FIGO scale and the residual disease after initial surgery are the only, wide-accepted and reliable prognostic factors in PFTC [12, 13, 21–23]. The depth of tubal invasion in the cases limited to the fallopian tube [19, 23], and the presence of lymphocytic infiltration have been suggested to play an unfavorable prognostic role in PFTCs.…”

Section: Introductionmentioning

confidence: 99%

“…The depth of tubal invasion in the cases limited to the fallopian tube [19, 23], and the presence of lymphocytic infiltration have been suggested to play an unfavorable prognostic role in PFTCs. The value of other commonly used prognostic factors did not find wider acceptance [12, 13].…”

Section: Introductionmentioning

confidence: 99%

MRP2 (ABCC2, cMOAT) expression in nuclear envelope of primary fallopian tube cancer cells is a new unfavorable prognostic factor

Hałoń

Materna

Donizy

et al. 2012

Arch Gynecol Obstet

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ObjectiveTo determine the prognostic value of the immunohistochemical evaluation of the multidrug resistance-associated protein 2 (MRP2) expression, together with its subcellular localization in primary fallopian tube carcinomas (PFTCs).MethodsThe immunohistochemical analysis was performed using samples originating from 70 patients with PFTCs.Results(1) We documented that MRP2 can be localized in the plasma membrane (MRP2c), as well as in the nuclear envelope (MRP2n) of the PFTC cells. (2) Patients with more advanced stage, with progression of the disease and patients who died, showed significantly higher expression of the MRP2n. (3) Univariate and multivariate analyses showed that MRP2n is an unfavorable prognostic factor in PFTCs. (4) The analysis of the classic clinicopathological data revealed that only the FIGO stage had prognostic value, both in the univariate, as well as in multivariate analysis.Conclusions(1) This study suggests that MRP2n is a new disadvantageous prognostic factor in PFTCs and (2) that expression in nuclear envelope can be associated with lower differentiation of cancer cells and their resistance to the cisplatin. (3) We have also confirmed independent prognostic value of FIGO stage in PFTCs.

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Prognostic features of carcinoma of the fallopian tube

Cited by 21 publications

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Preoperative Serum hCGβ as a Prognostic Marker in Primary Fallopian Tube Carcinoma

Preoperative Serum hCGβ as a Prognostic Marker in Primary Fallopian Tube Carcinoma

An unusual case of primary fallopian tube carcinoma in pregnancy

MRP2 (ABCC2, cMOAT) expression in nuclear envelope of primary fallopian tube cancer cells is a new unfavorable prognostic factor

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Prognostic features of carcinoma of the fallopian tube

Cited by 21 publications

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Preoperative Serum hCG&beta; as a Prognostic Marker in Primary Fallopian Tube Carcinoma

Preoperative Serum hCG&beta; as a Prognostic Marker in Primary Fallopian Tube Carcinoma

An unusual case of primary fallopian tube carcinoma in pregnancy

MRP2 (ABCC2, cMOAT) expression in nuclear envelope of primary fallopian tube cancer cells is a new unfavorable prognostic factor

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Preoperative Serum hCGβ as a Prognostic Marker in Primary Fallopian Tube Carcinoma

Preoperative Serum hCGβ as a Prognostic Marker in Primary Fallopian Tube Carcinoma