Prognostic features of the tumour microenvironment in oesophageal adenocarcinoma

McShane, Rhiannon; Arya, Swati; Stewart, Alan J.; Caie, Peter D.; Bates, Mark

doi:10.1016/j.bbcan.2021.188598

Cited by 13 publications

(5 citation statements)

References 189 publications

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“…It has been reported that cancer-associated fibroblasts have features that promote tumorigenesis [ 20 ]. To investigate the relationship between HSP90B1 expression and cancer-associated fibroblasts, three different algorithms, namely EPIC, MCPCOUNTER, and XCELL, were used.…”

Section: Resultsmentioning

confidence: 99%

A Pan-Cancer Analysis of Heat-Shock Protein 90 Beta1(HSP90B1) in Human Tumours

Wang

2022

Biomolecules

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Background: HSP90B1, a member of the heat-shock protein 90 family, plays a vital role as a molecular chaperone for oncogenes and stimulates tumour growth. However, its role in various cancers remains unexplored. Methods: Using the cancer genome atlas, gene expression omnibus the Human Protein Atlas databases and various other bioinformatic tools, this study investigated the involvement of HSP90B1 in 33 different tumour types. Results: The over-expression of HSP90B1 generally predicted poor overall survival and disease-free survival for patients with tumours, such as adrenocortical carcinoma, bladder urothelial carcinoma, kidney renal papillary cell carcinoma, and lung adenocarcinoma. In this study, HSP90B1 was highly expressed in the majority of tumours. A comparison was made between the phosphorylation of HSP90B1 in normal and primary tumour tissues, and putative functional mechanisms in HSP90B1-mediated oncogenesis were investigated. Additionally, the mutation burden of HSP90B1 in cancer was evaluated along with the survival rate of patients with cancer patients. Conclusion: This first pan-cancer investigation reveals the oncogenic functions of HSP90B1 in various cancers.

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Section: Resultsmentioning

confidence: 99%

A Pan-Cancer Analysis of Heat-Shock Protein 90 Beta1(HSP90B1) in Human Tumours

Wang

2022

Biomolecules

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“…), and varying expression of cell types and surface receptors. [9][10][11][12][13]97 TMEresponsive nanotherapeutics are diagnostic and therapeutic agents specifically engineered to target the TME in cancer and are capable of responding to specific conditions or signals within the TME, thereby achieving precise diagnosis and treatment. 13,98 These nanotherapeutics hold significant promise in the realms of cancer theranostics, as they have the potential to enhance treatment effectiveness, minimize side effects, and propel the advancement of personalized medicine.…”

Section: Tme-triggered Degradable Silica Nanoparticles For Precision ...mentioning

confidence: 99%

“…It exhibits distinctive features, such as dynamic hypoxia, high concentrations of redox components, elevated intracellular adenosine triphosphate (ATP) and lactate levels, and extracellular acidosis. [6][7][8][9][10][11][12][13] Additionally, certain types of tumors possess specific microenvironments. Vascular tumors are characterized by vascular leakage, chaotic branching of blood vessels, uneven blood flow distribution, and high stromal fluid pressure, while stromal tumors present prominent features of abnormal tumor-associated fibroblasts and a dense extracellular matrix.…”

Section: Introductionmentioning

confidence: 99%

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

Zhang,

Tang,

Liu

et al. 2024

Nanoscale Horiz.

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“…The tumor microenvironment (TME) consists of a multifaceted network of immune cells, stromal cells, extracellular matrix constituents, and signaling molecules collaboratively control the development, advancement, and metastasis of the tumor [8][9][10]. Recent studies have highlighted the AGING significance of immune cell infiltration within the TME, as it has been demonstrated to impact cancer prognosis and treatment effectiveness [11][12][13]. For example, an association has been demonstrated between a more favorable prognosis and the presence of cytotoxic T lymphocytes and so on.…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of long non-coding RNA USP30-AS1 in ovarian cancer: insights into immune cell infiltration in the tumor microenvironment

Xiong,

Chen,

Sun

et al. 2023

Aging

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Ovarian cancer represents a formidable gynecologic malignancy bearing a dismal prognosis owing to the dearth of reliable early detection approaches and a high recurrence rate. Long non-coding RNAs (lncRNAs) have garnered immense attention as key orchestrators involved in diverse biological processes and take part in cancer initiation and progression. The present study investigated the potential significance of lncRNA USP30-AS1 in ovarian cancer prognosis, as well as its putative association with immune cell infiltration in tumor immune microenvironment (TIME). By analyzing publicly available datasets, we identified six lncRNAs with prognostic prediction ability, including USP30-AS1. The results revealed a significant positive correlation of USP30-AS1 expression with the infiltration of immune cells such as Th1 cells, TFH, CD8 T cells, B cells, antigenpresenting dendritic cells (aDC), and plasmacytoid dendritic cells (pDC) in ovarian cancer specimens. These findings provide compelling evidence of the potential involvement of lncRNA in the regulation of the TME in ovarian carcinoma. The outcomes from this study underscore the potential of USP30-AS1 as a promising prognostic biomarker for ovarian cancer. Additionally, the findings offer significant insights into the plausible role of lncRNAs in modulating immune activities, thus adding to our understanding of the disease biology. Additional investigations are necessary to unravel the molecular mechanisms underpinning these connections and validate the results seen in independent cohorts and experimental models.

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Prognostic features of the tumour microenvironment in oesophageal adenocarcinoma

Cited by 13 publications

References 189 publications

A Pan-Cancer Analysis of Heat-Shock Protein 90 Beta1(HSP90B1) in Human Tumours

A Pan-Cancer Analysis of Heat-Shock Protein 90 Beta1(HSP90B1) in Human Tumours

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

Prognostic role of long non-coding RNA USP30-AS1 in ovarian cancer: insights into immune cell infiltration in the tumor microenvironment

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