Prognostic impact of gene polymorphisms in patients with idiopathic sudden sensorineural hearing loss

Kitoh, Ryosuke; Nishio, Shin‐ya; Usami, Shin‐ichi

doi:10.1080/00016489.2017.1296971

Cited by 15 publications

(10 citation statements)

References 19 publications

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“…28 Data in the current literature show that several genetic polymorphisms correlated with oxidative stress, inflammation, thrombosis, and blood vessel permeability are associated to SSNHL predisposition and development. 10,12,20,24,28,36,37,40,41 On the basis of this evidence, it could be hypothesized that genetic factors could play a role in maintaining the delicate balance between ROS and antioxidants, pro-inflammatory and anti-inflammatory factors, proaggregants, and antiaggregants; since the balance among these factors is important for the inner ear homeostasis, their disruption could be a factor contributing to the ISSNHL onset. Furthermore, a possible link between SSNHL and major cardiovascular diseases, such as stroke and myocardial infarction, has been previously highlighted.…”

Section: Discussionmentioning

confidence: 99%

“…1,46,47 Genetic polymorphisms have also been shown to be related to hearing prognosis. 41 The data in the literature suggest that some genetic factors could confer a resistance to treatment, particularly to steroids. 34 The identification of the ISSNHL susceptibility genes could be important in the prediction of the treatment outcome and possibly could help physicians in choosing the most suitable therapeutic option (ie, tailored therapy).…”

Section: Discussionmentioning

confidence: 99%

“…Genetic polymorphisms have been investigated as possible prognostic factors after oral steroid therapy. 41 Kitoh et al 41 analyzed the correlation between genes related to oxidative stress or steroids receptors and ISSNHL hearing prognosis. They found a relationship between the presence of glutathione-disulfide reductase (GSR) rs2251780, rs3779647, nitric oxide synthases 3 (NOS3) rs1799983 polymorphisms, and a poor steroid-therapy outcome.…”

Section: Genetic Polymorphisms and Inner Ear Inflammation And/or Oxidative Stressmentioning

confidence: 99%

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Genetic Polymorphisms in Sudden Sensorineural Hearing Loss: An Update

et al. 2020

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Objective: To investigate the association between genetic polymorphisms and sudden sensorineural hearing loss (SSNHL). Most of the SSNHL cases still remain idiopathic, and several etiopathogenetic hypotheses, including a genetic predisposition, have been proposed. Methods: A literature review was conducted using different databases: Medline/PubMed, EMBASE, and CINAHL, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All databases have been searched from May 2016 to April 2020. Results: Genetic susceptibility could represent a key element in the pathogenesis of SSNHL. A number of genetic polymorphisms related to (1) inner ear microvascular disease and endothelial dysfunction and (2) to inner ear oxidative stress and inflammation have been addressed in the current literature. Conclusions: The potential identification of a genetic profile related to SSNHL could provide a more accurate prognostic evidence of idiopathic SSNHL (ISSNHL), offering to the patients not only early-prevention strategies but eventually information on various inheritance modalities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Genetic Polymorphisms and Inner Ear Inflammation And/or Oxidative Stressmentioning

confidence: 99%

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Genetic Polymorphisms in Sudden Sensorineural Hearing Loss: An Update

et al. 2020

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“…In addition, the glucocorticoid receptor gene (NR3C1), mineralocorticoid receptor gene (NR3C2), and glucocorticoid-related gene (FKBP5) also had been evaluated among SSNHL patients in Japan [Kitoh et al, 2016]. However, up to now, no polymorphism of steroid hormone receptor genes was found to be associated with the prevalence of SSNHL, while a recent study showed that the SNP of the NR3C1 gene (rs4912910) may have a marginal correlation with the prognosis of SSNHL [Kitoh et al, 2017].…”

Section: Superoxide Dismutase Genesmentioning

confidence: 99%

Genetic Polymorphisms and Susceptibility to Sudden Sensorineural Hearing Loss: A Systematic Review

et al. 2019

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Background: Recently, genetic factors have been considered as an important risk factor for sudden sensorineural hearing loss (SSNHL). Many studies analyzed the association between SSNHL and polymorphisms. However, most of them gave inconclusive results. Key Message: We performed a systematic review to find out the association between polymorphisms and susceptibility to SSNHL. Finally, 47 studies involving 5,230 SSNHL patients and 68 genes were included for analysis and discussion of results. Polymorphisms in 26 genes have been suggested to be correlated with the susceptibility to SSNHL. Summary: Although a great number of studies support that polymorphisms in genes are associated with susceptibility to SSNHL, we need large multicenter studies, which evaluate multiple single nucleotide polymorphisms in SSNHL patients, to find real genetic risk factors for susceptibility to SSNHL. This is very helpful in designing more effective prevention and treatment strategies for patients with SSNHL.

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“…A study on twins and their family members showed that heritability was 0.7 or higher, which indicated the important role of genetic factors in hearing [18]. Genetic studies on humans have reported many ARHI-related genes, such as GRM7, SIK3, ESRRG , SOD2, GSTM1, GRHL2, TRIOBP, and a study have shown that NR3C1 may be associated with sudden sensorineural hearing loss [2,18,23]. However, few studies have explored the relationship between NR3C1 gene and ARHI.…”

Section: Introductionmentioning

confidence: 99%

Association between NR3C1 gene polymorphisms and age-related hearing impairment in Qingdao Chinese elderly

et al. 2021

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Background Age-related hearing impairment (ARHI) has attracted increasing attention recently. It is caused by genetic and environmental factors. A number of ARHI-related genes have been found. This study aimed to detect the potential association between NR3C1 gene polymorphisms and ARHI by means of weighted allele score. Methods A total of 861 participants from Qingdao city were selected by means of cluster random sampling. We statistically evaluated the characteristics of individuals and used the Mann–Whitney U test or chi-square test for comparison. The publicly available expression quantitative trait locus (eQTL) was queried on the website of the Genotype-Tissue Expression (GTEx). We used the weighted allele score and logistic regression analysis to explore the association between NR3C1 gene polymorphisms and ARHI. Finally, the prediction model was constructed by logistic regression and receiver operating characteristic (ROC) curve. Results All individuals over 60 years of age were enrolled in this study. The allele of rs61757411, rs41423247 and rs6877893 were significantly different between the ARHI group and the normal hearing group (P < 0.01). Though eQTL analysis, rs6877893 and rs33388 might affect the occurrence of ARHI by affecting the expression of NR3C1 gene in artery aorta. Then we performed two models: one without adding any covariates into model and the other adjusting for demographic characteristic, smoking and drinking, diet and exercise, and physical conditions. In the multivariate-adjusted model 2, the odds ratio with 95% confidence interval for weighted allele score (NR3C1) was 0.841 (0.710–0.995, P = 0.043). The area under the ROC curve was 0.755, indicating that the model had good predictability. Conclusions Our study suggests that NR3C1 gene polymorphisms was significantly associated with ARHI.

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Prognostic impact of gene polymorphisms in patients with idiopathic sudden sensorineural hearing loss

Cited by 15 publications

References 19 publications

Genetic Polymorphisms in Sudden Sensorineural Hearing Loss: An Update

Genetic Polymorphisms in Sudden Sensorineural Hearing Loss: An Update

Genetic Polymorphisms and Susceptibility to Sudden Sensorineural Hearing Loss: A Systematic Review

Association between NR3C1 gene polymorphisms and age-related hearing impairment in Qingdao Chinese elderly

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