Prognostic impact of geriatric nutritional risk index on patients with urological cancers: A meta-analysis

Abstract

BackgroundDespite previous research examining the predictive value of the geriatric nutritional risk index (GNRI) in individuals with urological cancers (UCs), results have been conflicting. This study aimed to comprehensively explore the potential link between GNRI and the prognosis of UCs using a meta-analysis.MethodsThe Cochrane Library, PubMed, Embase, and Web of Science databases were systematically and exhaustively searched. We estimated the prognostic importance of the GNRI in patients with UCs by calculating the pooled hazard ratios (HRs) and 95% confidence intervals (CIs) on survival outcomes. Publication bias was identified using Egger’s test and Begg’s funnel plot.ResultsEight trials with 6,792 patients were included in our meta-analysis. Patients with UCs who had a lower GNRI before treatment had a higher risk of experiencing worse overall survival (HR = 2.62, 95% CI = 1.69–4.09, p < 0.001), recurrence-free survival/progression-free survival (HR = 1.77, 95% CI = 1.51–2.08, p < 0.001), and cancer-specific survival (HR = 2.32, 95% CI = 1.28–4.20, p = 0.006). Moreover, the subgroup analysis did not change the predictive significance of the GNRI in individuals with UCs. Neither Egger’s nor Begg’s test indicated substantial bias in this analysis.ConclusionAs a result of our meta-analysis, we found that a low GNRI strongly predicts poor prognosis for patients with UCs. A lower pretreatment GNRI indicates poor survival outcomes in UCs.

Prognostic and clinicopathological role of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: A meta-analysis

“…Recent meta-analyses have reported that the GNRI significantly predicts cancer prognosis (34)(35)(36)(37)(38). Zhang et al conducted a meta-…”

“…A recent meta-analysis involving 3,440 participants showed that a lower GNRI before treatment predicted poorer OS and disease-free survival of colorectal cancer cases ( 40 ). Another meta-analysis enrolling 6,792 patients indicated that a lower GNRI strongly estimated dismal OS, RFS/PFS, and CSS in urological cancers ( 38 ). According to Wang et al., a low GNRI predicted dismal OS, RFS, and CSS in lung cancer cases ( 41 ).…”

Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta‐analysis

“…Numerous meta-analyses have investigated the GNRI's prognostic value in human malignancies, including in esophageal cancer, 18 pancreatic cancer, 36 lung cancer, 37 urological cancer, 38 and colorectal cancer. 39 In line with those of the aforementioned studies, the results of our study support that the GNRI is a valuable prognostic indicator for patients with HNC.…”