Prognostic impact of intratumoral vessel invasion in completely resected pathologic stage I non–small cell lung cancer

Abstract

The current study indicated that intratumoral vessel invasion and pleural invasion are independent prognostic factors. Intratumoral vessel invasion status can complement the size-dependent TNM staging system in pathologic stage I non-small cell lung cancer.

Prognostic impact of nm23‐H1 and PCNA expression in pathologic stage I non‐small cell lung cancer

“…Although the clinic-pathologic staging system has been the standard for determining NSCLC prognosis [2], this classification scheme is probably an imprecise predictor of the prognosis of an individual patient. Five-year survivals in resected stage IA and IB disease were 67-89% and 57-75%, respectively [3,4]. One of the reasons for this variation is that stage I NSCLC includes populations with a different grade of malignancy [4].…”

“…Five-year survivals in resected stage IA and IB disease were 67-89% and 57-75%, respectively [3,4]. One of the reasons for this variation is that stage I NSCLC includes populations with a different grade of malignancy [4]. This observation underlines how important it is to identify novel pathological parameters in addition to disease stage and, most of all, new biological markers, in order to add further prognostic information, select high-risk patients for aggressive adjuvant treatments [5].…”

18F-FDG uptake in primary lung cancer as a predictor of intratumoral vessel invasion

“…Intratumoral vessel invasion (IVI) of lymphatic vessels (IVI-L) or blood vessels (IVI-V) is an important pathological factor for lung carcinoma, both because it predicts metastasis and it has been shown to be an independent determinant of a poor prognosis in non-small cell lung carcinoma, especially in the early stages [5][6][7]. In addition, adjuvant chemotherapy can be beneficial for patients with stage IA lung carcinoma with IVI [8].…”

Interstitial growth as an aggressive growth pattern in primary lung cancer

“…Vascular invasion is associated with unfavorable prognosis in NSCLC (Bodendorf et al 2009;Gabor et al 2004;Kessler et al 1996;Miyoshi et al 2009;Poncelet et al 2008;Rigau et al 2002). We previously reported that vascular invasion could be classified as intratumoral or extratumoral, according to its location (Maeda et al 2010).…”