Prognostic impact of lung adenocarcinoma second predominant pattern from a large European database

Bertoglio, Pietro; Querzoli, Giulia; Ventura, Luigi; Aprile, Vittorio; Cattoni, Maria; Nachira, Dania; Lococo, Filippo; Perez, Maria Rodriguez; Guerrera, Francesco; Minervini, Fabrizio; Gnetti, Letizia; Bacchin, Diana; Franzi, Francesca; Rindi, Guido; Bellafiore, Salvatore; Femia, Federico; Viti, Andrea; Bogina, Giuseppe; Kestenholz, Peter; Ruffini, Enrico; Paci, Massimiliano; Margaritora, Stefano; Imperatori, Andrea; Lucchi, Marco; Ampollini, Luca; Terzi, Alberto

doi:10.1002/jso.26292

Cited by 12 publications

(19 citation statements)

References 21 publications

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“…The 5-year recurrence rate was 5.6% (39 cases). Age, gender, and tumor size have been recognized as prognostic factors for both RFS and OS in previous studies involving early-stage lung adenocarcinoma (3,12,14,19,20). In this study, the MP/S + Lep − subtype was identified as an independent poor prognostic factor of both RFS and OS in "intermediate-grade" lung adenocarcinomas.…”

Section: Discussionmentioning

confidence: 56%

“…However, the impact of the SPP remains controversial (4,11,15). A recent European multicenter study found no significant difference in terms of DFS according to SPP (14).…”

Section: Discussionmentioning

confidence: 99%

“…Yanagawa reported that patients with a solid or micropapillary pattern as a minor component had poor prognosis (13). However, recent findings from a large European database study concluded that there was no difference in recurrence-free survival (RFS) according to the SPP (P=0.522) (14). We hypothesize that every single pathological component of the cancer that is present is one of the important reasons for the heterogeneity of "intermediategrade" adenocarcinomas and lead to different prognosis, rather than just one or two major components.…”

Section: Introductionmentioning

confidence: 99%

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The presence of lepidic and micropapillary/solid pathological patterns as minor components has prognostic value in patients with intermediate-grade invasive lung adenocarcinoma

Hou¹,

Song²,

Chen³

et al. 2022

Transl Lung Cancer Res

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Background: The acinar-and papillary-predominant histological subtypes are the most common types of invasive lung adenocarcinoma and are considered "intermediate-grade" carcinomas with heterogeneous prognosis. This study investigated the prognostic significance of the lepidic and micropapillary/solid pathological patterns as minor components in patients with intermediate-grade lung adenocarcinomas.Methods: A total of 697 patients with pathological N0M0 acinar/papillary-predominant lung adenocarcinomas ≤3 cm in diameter, who underwent curative resection in our institution between June 1, 2014 and August 31, 2016, were retrospectively enrolled in this study. Acinar/papillary-predominant lung adenocarcinomas were classified into four subtypes according to the presence of the minor pathological components lepidic (Lep), micropapillary (MP), and solid (S). The subtypes were MP

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Section: Discussionmentioning

confidence: 56%

“…However, the impact of the SPP remains controversial (4,11,15). A recent European multicenter study found no significant difference in terms of DFS according to SPP (14).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The presence of lepidic and micropapillary/solid pathological patterns as minor components has prognostic value in patients with intermediate-grade invasive lung adenocarcinoma

Hou¹,

Song²,

Chen³

et al. 2022

Transl Lung Cancer Res

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“…Due to its rarity, little information on the incidence, features, and prognosis of PACC is known. 10 As a result, the current study evaluated a cohort of PACC patients from SEER registrations across the United States. This analysis supports a variety of critical conclusions.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors and survival outcome of primary pulmonary acinar cell carcinoma

Meng

Sun

Wang³

et al. 2021

Thoracic Cancer

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The objective of our study was to investigate the epidemiologic characteristics and prognostic factors in patients with pulmonary acinar cell carcinoma (PACC). Methods: PACC patients diagnosed between 1975 and 2016 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. The trend in PACC incidence was assessed using joinpoint regression software. Overall survival (OS) and disease-specific survival (DSS) were evaluated using the Kaplan-Meier method and logrank test. Univariate and multivariate Cox regression analysis was performed to identify the independent prognostic factors for OS and DSS. Nomograms to predict survival possibilities were constructed based on the identified independent prognostic factors. Results: A total of 2918 patients were identified with PACC. The mean age was 65.2 AE 8.95 years with a female to male of 1.6:1. The incidence of PACC steadily increased by an annual percentage change (APC) of 3.2% (95% CI 2.1-4.4, p < 0.05). Multivariate Cox regression analysis revealed that age, gender, race, stage, grade, tumor size, number of positive lymph nodes, surgery, and chemotherapy were independent prognostic factors for survival. Nomograms specifically for PACC were constructed to predict 1-and 5-year OS and DSS possibility, respectively. The concordance index (C-index) and calibration plots showed the established nomograms had robust and accurate performance. Conclusion: PACC was rare but the incidence has been steadily increasing over the past four decades. Survival has improved in recent years. Surgery or chemotherapy could provide better OS and DSS. The established nomograms specifically for PACC were robust and accurate in predicting 1-and 5-year OS and DSS.

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“…Lung cancer is the leading cause of death of cancer worldwide, and adenocarcinoma is the most frequent histotype [ 1 ]. In 2011, the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification [ 2 ] redefined several different patterns of lung adenocarcinomas, which differed not only according to their pathological features, but also according to their clinical behaviours, with a crucial impact on long-term outcomes, as demonstrated in several reports [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Pathological and clinical features of multiple cancers and lung adenocarcinoma: a multicentre study

Bertoglio

Ventura

Aprile

et al. 2022

Interactive CardioVascular and Thoracic Surgery

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OBJECTIVES Lung cancer is increasingly diagnosed as a second cancer. Our goal was to analyse the characteristics and outcomes of early-stage resected lung adenocarcinomas in patients with previous cancers (PC) and correlations with adenocarcinoma subtypes. METHODS We retrospectively reviewed data of patients radically operated on for stage I–II lung adenocarcinoma in 9 thoracic surgery departments between 2014 and 2017. Overall survival (OS) and time to disease relapse were evaluated between subgroups. RESULTS We included 700 consecutive patients. PC were present in 260 (37.1%). Breast adenocarcinoma, lung cancer and prostate cancer were the most frequent (21.5%, 11.5% and 11.2%, respectively). No significant differences in OS were observed between the PC and non-PC groups (P = 0.378), with 31 and 75 deaths, respectively. Patients with PC had smaller tumours and were more likely to receive sublobar resection and to be operated on with a minimally invasive approach. Previous gastric cancer (P = 0.042) and synchronous PC (when diagnosed up to 6 months before lung adenocarcinoma; P = 0.044) were related, with a worse OS. Colon and breast adenocarcinomas and melanomas were significantly related to a lower incidence of high grade (solid or micropapillary, P = 0.0039, P = 0.005 and P = 0.028 respectively), whereas patients affected by a previous lymphoma had a higher incidence of a micropapillary pattern (P = 0.008). CONCLUSIONS In patients with PC, we found smaller tumours more frequently treated with minimally invasive techniques and sublobar resection, probably due to a more careful follow-up. The impact on survival is not uniform and predictable; however, breast and colon cancers and melanoma showed a lower incidence of solid or micropapillary patterns whereas patients with lymphomas had a higher incidence of a micropapillary pattern.

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Prognostic impact of lung adenocarcinoma second predominant pattern from a large European database

Cited by 12 publications

References 21 publications

The presence of lepidic and micropapillary/solid pathological patterns as minor components has prognostic value in patients with intermediate-grade invasive lung adenocarcinoma

The presence of lepidic and micropapillary/solid pathological patterns as minor components has prognostic value in patients with intermediate-grade invasive lung adenocarcinoma

Prognostic factors and survival outcome of primary pulmonary acinar cell carcinoma

Pathological and clinical features of multiple cancers and lung adenocarcinoma: a multicentre study

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