Prognostic impact of microRNA-related gene polymorphisms on survival of patients with colorectal cancer

Lee, Hyun-Chul; Kim, Jong Gwang; Chae, Yee Soo; Sohn, Sang Kyun; Kang, Byung Woog; Moon, Joon Ho; Jeon, Seong Woo; Lee, Myung-Hoon; Lim, Kyoung-Hoon; Park, Jin Young; Choi, Gyu Seog; Jun, Soo Han

doi:10.1007/s00432-009-0754-6

Cited by 50 publications

(44 citation statements)

References 15 publications

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“…Furthermore, other epidemiological studies have reported the association of the C allele with increased risk of congenital heart disease (26), hepatocellular carcinoma (27) and gastric cancer (28). To our knowledge, there have been only two studies that have investigated the prognostic impact of the hsa-mir-196a2 polymorphism in colorectal cancer (14,16). Consistent with our result, these studies also failed to identify any significance of the hsa-mir-196a2 C polymorphism as a prognostic biomarker.…”

Section: Discussionsupporting

confidence: 82%

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Prognostic significance of microRNA gene polymorphisms in patients with surgically resected colorectal cancer

Jang

Kim

Min

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. MicroRNAs (miRNAs) are small 19-to 22-nucleotide sequences of RNA that participate in the regulation of cell differentiation, cell cycle progression and apoptosis. Although single-nucleotide polymorphisms (SNPs) in miRNA regions are considered unlikely to be functionally important, nucleotide variations within the sequences of primary (pri)-or precursor (pre)-miRNAs may affect miRNA processing and ultimately result in the modification of miRNA expression. The aim of this study was to investigate associations between four SNPs in pre-miRNA genes and the survival of colorectal cancer patients. A total of 407 colorectal patients were consecutively enrolled. DNA was extracted from blood specimens, and the hsa- mir-146aC>G, hsa-mir-149C>T, hsa-mir-196a2C>T and hsa-mir-499A>G polymorphisms were genotyped by PCR-RFLP. We were unable to identify independent prognostic SNPs for colorectal cancer. However, the heterozygous TC genotype of the 196a2C>T polymorphism was a significant risk factor for the overall survival of rectal cancer patients (HR=3.554, 95% CI 1.296-9.747, p=0.014). Further largepopulation studies are warranted to define the 196a2C>T polymorphism as a prognostic factor of rectal cancer.

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Section: Discussionsupporting

confidence: 82%

“…However, there were few associations identified for SNPs in pre-miRNA with prognostic significance in colorectal cancer patients (14)(15)(16). In the present study, we investigated whether polymorphisms in pre-miRNA genes influence the outcome of patients with surgically resected colorectal cancer.…”

Section: Introductionmentioning

confidence: 93%

Prognostic significance of microRNA gene polymorphisms in patients with surgically resected colorectal cancer

Jang

Kim

Min

et al. 2011

Experimental and Therapeutic Medicine

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“…Hence, there is a need for studies for evaluating the role of various miRNAs in progression of the GERD>BE>EAC pathway. Recently, it has been shown that genetic polymorphisms in miRNA encoding genes and miRNA binding sites (3′ UTR of genes) may have a role in the disease [55][56][57][58][59].…”

Section: Mirnas In Be and Eacmentioning

confidence: 99%

Genetic factors in the pathogenesis of gastroesophageal reflux disease

Ghoshal

Chourasia

2011

Indian J Gastroenterol

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Multiple factors play a role in the pathogenesis of gastroesophageal reflux disease (GERD). Two landmark studies showing higher concordance of disease in monozygotic than dizygotic twin pairs suggested the role of host genetic factors in its pathogenesis. Recent studies have shown that genetic polymorphism in genes influencing host's inflammatory response, drug metabolism, cell cycle regulation, xenobiotic pathways, DNA repair, mutagenesis, esophageal sensory function and gene silencing are associated with risk of GERD and its sequelae-Barrett's esophagus and esophageal adenocarcinoma. However, more studies on larger sample size are needed before reaching a definite conclusion on the role of an individual gene.

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“…Genetic variants in miRNA biogenesis pathway genes have been shown to be associated with the risk of several cancers or related diseases such as bladder cancer [13], esophageal cancer [14], renal cell carcinoma [15], prostate cancer [16], and premalignant oral lesions [17] and the prognosis of colorectal cancer [18], and renal cell carcinoma [18,19]. However, as yet, no study has shown the association between the polymorphisms in the miRNA biogenesis pathway genes and the risk of breast cancer.…”

Section: Introductionmentioning

confidence: 96%

Common genetic polymorphisms of microRNA biogenesis pathway genes and risk of breast cancer: a case–control study in Korea

Sung

Lee

Choi

et al. 2011

Breast Cancer Res Treat

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Recent compelling evidence indicates that mutation, aberrant expression, and dysregulation of microRNA (miRNA) biogenesis are implicated in cancer development and progression. Based on the important role of miRNA biogenesis pathway in carcinogenesis, we hypothesized that genetic variations in this pathway genes may play a role as susceptibility factors for breast cancer. To test this hypothesis, we investigated the associations between 41 single nucleotide polymorphisms (SNPs) in 14 genes involved in miRNA biogenesis pathway and breast cancer risk in a case-control study of 559 Korean breast cancer cases and 567 controls frequency-matched by age. In all women, 3 SNPs (AGO1 rs595055, AGO2 rs3864659, and p68 rs1991401) were significantly associated with breast cancer risk. In stratified analysis by menopausal status, altered risk associations were observed for 7 SNPs in postmenopausal breast cancer. When subjects were grouped by the number of high-risk genotypes, we found a progressive increase in gene-dosage effect (P (trend) = 9.46E-7). The protective effects of AGO2 rs3864659 and HIWI rs11060845 were more pronounced in progesterone receptor-positive (PR+) cancer than in progesterone receptor-negative (PR-) cancer (odds ratio (OR), 0.50; 95% confidence interval (CI), 0.30-0.84 vs. OR, 0.94; 95% CI, 0.60-1.84; P (heterogeneity) = 0.04 and OR, 0.57; 95% CI, 0.37-0.88 vs. OR, 0.97; 95% CI, 0.65-1.44; P (heterogeneity) = 0.02, respectively), and the DROSHA rs644236 had stronger association with estrogen receptor-negative (ER-) cancer than for estrogen receptor-positive (ER+) cancer (OR, 1.39; 95% CI, 1.08-1.78 vs. OR, 1.05; 95% CI, 0.85-1.29; P (heterogeneity) = 0.04). Our results suggest that genetic variants in miRNA biogenesis pathway genes may be associated with breast cancer risk, and the modifiable effects might be different according to the menopausal status and hormone receptor status.

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Prognostic impact of microRNA-related gene polymorphisms on survival of patients with colorectal cancer

Cited by 50 publications

References 15 publications

Prognostic significance of microRNA gene polymorphisms in patients with surgically resected colorectal cancer

Prognostic significance of microRNA gene polymorphisms in patients with surgically resected colorectal cancer

Genetic factors in the pathogenesis of gastroesophageal reflux disease

Common genetic polymorphisms of microRNA biogenesis pathway genes and risk of breast cancer: a case–control study in Korea

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