Prognostic Impact of MITD1 and Associates With Immune Infiltration in Kidney Renal Clear Cell Carcinoma

Abstract

Kidney renal clear cell carcinoma (KIRC) is one of the most malignant diseases with poor survival rate over the world. The tumor microenvironment (TME) is highly related to the oncogenesis, development, and prognosis of KIRC. Thus, making the identification of KIRC biomarkers and immune infiltrates critically important. Microtubule Interacting and Trafficking Domain containing 1(MITD1) was reported to participate in cytokinesis of cell division. In the present study, multiple bioinformatics tools and databases were applied to investigate the expression level and clinical value of MITD1 in KIRC. We found that the expression of MITD1 was significantly increased in KIRC tissues. Further, the KIRC patients with high MITD1 levels showed a worse overall survival (OS) rate and disease free survival (DFS) rate. Otherwise, we found a significant correlation MITD1 expression and the abundance of CD8+ T cells. Functional enrichment analyses revealed that immune response and cytokine-cytokine receptor are very critical signaling pathways which associated with MITD1 in KIRC. In conclusion, our findings indicated that MITD1 may be a potential biomarker and associated with immune infiltration in KIRC.

Pan-Cancer Analysis of the Prognostic and Immunotherapeutic Value of MITD1

“…Nonetheless, a few studies have revealed that MITD1 plays multiple roles in the progression of various cancers. MITD1 may serve as a biomarker for LIHC and KIRC [ 11 , 14 ]. MITD1 might also inhibit the migration of BLCA cells [ 13 ].…”

“…The absence of MITD1 leads to instability of the midbody and abscission failure, and the depletion of MITD1 leads to increased blebbing and premature abscission in cells [ 6 ]. ESCRT-III plays a critical role in several cancers, such as pancreatic tumors [ 8 ], prostate cancer [ 9 ], ovarian cancer [ 10 ], kidney renal clear cell carcinoma [ 11 , 12 ], bladder cancer [ 13 ], and liver cancer [ 14 ]. Moreover, disorders of abscission in cytokinesis can cause genomic instability and tumorigenesis [ 15 ], implying the existence of a network of interactions between MITD1 and the tumor microenvironment (TME), microsatellite instability (MSI), tumor mutational burden (TMB), homologous recombination deficiency (HRD), and ploidy.…”

Rho GTPase-activating protein 4 is upregulated in Kidney Renal Clear Cell Carcinoma and associated with poor prognosis and immune infiltration

“…It is reported that the 5-year disease-specific survival rate of patients with RCC stage IV is less than 10% [2]. KIRC is the main subtype of RCC, with the highest incidence, accounting for about 80% of all RCCs.…”