2015
DOI: 10.1016/j.ijom.2014.10.006
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Prognostic impact of perineural invasion and lymphovascular invasion in advanced stage oral squamous cell carcinoma

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Cited by 132 publications
(129 citation statements)
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“…results could be explained with the postoperative irradiation, though we found no evidence for less recurrence after adjuvant treatment in general. Similar to recent reports about the role of histologic risk factors [26], in our study, perineural or lymphovascular invasion was significantly associated with initial positive nodes. The rate of 13.3% of histopathological confirmed lymph node metastases recorded in the present study is below the listed range of 17-54% specifically mentioned for maxillary OSCC in related cohort studies [11,19,22,23,[27][28][29][30].…”
Section: Discussionsupporting
confidence: 91%
“…results could be explained with the postoperative irradiation, though we found no evidence for less recurrence after adjuvant treatment in general. Similar to recent reports about the role of histologic risk factors [26], in our study, perineural or lymphovascular invasion was significantly associated with initial positive nodes. The rate of 13.3% of histopathological confirmed lymph node metastases recorded in the present study is below the listed range of 17-54% specifically mentioned for maxillary OSCC in related cohort studies [11,19,22,23,[27][28][29][30].…”
Section: Discussionsupporting
confidence: 91%
“…Jardim et al 13 and Kosec et al 14 have both recently showed that the presence of PNS is a negative prognostic factor for patient outcomes. Broadly speaking, patients are treated with either combination surgery and radiotherapy, radiation alone or with palliation.…”
Section: Discussionmentioning
confidence: 99%
“…LVI and the POI have been identified as histological parameters that may predict more aggressive tumour biology in early‐stage oral cavity SCC . Therefore, the ability of pathologists to reproducibly identify LVI and classify the POI is clinically relevant.…”
Section: Discussionmentioning
confidence: 99%