Prognostic Impact of Plasma Glucose on Patients With Cardiogenic Shock With or Without Diabetes Mellitus from the SMART RESCUE Trial

Choi, Seung Kang; Yoon, Gwang-Seok; Lee, Man−Jong; Park, Sang‐Don; Ko, Young–Guk; Ahn, Chul‐Min; Yu, Cheol Woong; Chun, Woo Jung; Jang, Woo Jin; Kim, Hyun‐Joong; Kim, Bum Sung; Bae, Jang‐Whan; Lee, Sang Yeub; Kwon, Sung Uk; Kim, Je Sang; Lee, Wang Soo; Jeong, Jin‐Ok; Lim, Sung Mook; Cho, Sungsoo; Yang, Jeong Hoon; Gwon, Hyeon‐Cheol

doi:10.1016/j.amjcard.2022.04.008

Cited by 4 publications

(2 citation statements)

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“…Notably, the majority of research on this topic has been confined to patients experiencing AMI complicated by CS or have excluded patients after cardiac arrest [ 24 – 29 ]. However, a limited number of studies analyzed glucose in a real-world-setting of CS, encompassing various etiologies and severity levels, from beginning CS characterized by hypotension and signs of organ hypoperfusion to severe cases requiring resuscitation [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Blood glucose and lactate levels as early predictive markers in patients presenting with cardiogenic shock: A retrospective cohort study

Billig,

Al Zaidi,

Quacken

et al. 2024

PLoS ONE

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Lactate and glucose are widely used biochemical parameters in current predictive risk scores for cardiogenic shock. Data regarding the relationship between lactate and glucose levels in cardiogenic shock are limited. Thus, we aimed to analyze glucose and lactate as early markers for in-hospital mortality in cardiogenic shock. In this retrospective cohort study, 312 patients presenting with cardiogenic shock to a tertiary-care hospital between 2016 and 2018 were included. Apparent cardiogenic shock was defined as hypoperfusion with hemodynamic compromise and biochemical marker increase due to diminished tissue perfusion, corresponding to SCAI shock stages. In-hospital mortality was assessed as the primary endpoint. The median age of the study population was 71 (60–79) years and the etiology of cardiogenic shock was acute myocardial infarction in 45.8%. Overall in-hospital mortality was 67.6%. In the receiver operating curve analysis, the area under the receiver-operating curve (AUC) for prediction of in-hospital mortality was higher for lactate (AUC: 0.757) than for glucose (AUC: 0.652). Both values were significantly associated with outcome (groups created with best cutoff values obtained from the Youden index). Correlation analysis showed a significant non-linear association of both values. In a multivariable stepwise Cox regression analysis, lactate remained an independent predictor for in-hospital mortality, whilst glucose, despite being implicated in energy metabolism, was not independently predictive for mortality. Together, these data suggest that lactate at admission is superior for mortality prediction in patients with apparent cardiogenic shock. Glucose was not independently predictive for mortality.

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Section: Introductionmentioning

confidence: 99%

Blood glucose and lactate levels as early predictive markers in patients presenting with cardiogenic shock: A retrospective cohort study

Billig,

Al Zaidi,

Quacken

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Many interventional cardiologists have wandered around the idea of reducing the mortality of STEMI patients. Even after successful primary coronary intervention (PCI) with complete revascularization of coronary arteries, patients still suffer from devastating consequences (5)(6)(7). Most common phenomenon regarding mortality after successful PCI is mechanical complication after revascularization.…”

mentioning

confidence: 99%