Prognostic impact of tumour–stroma ratio in early‐stage oral tongue cancers

Almangush, Alhadi; Heikkinen, Ilkka; Bakhti, Nassira; Mäkinen, Laura K.; Kauppila, Joonas H.; Pukkila, Matti; Hagström, Jaana; Laranne, Jussi; Soini, Ylermi; Kowalski, Luiz Paulo; Grénman, Reidar; Haglund, Caj; Mäkitie, Antti; Coletta, Ricardo D.; Leivo, Ilmo; Salo, Tuula

doi:10.1111/his.13481

Cited by 60 publications

(112 citation statements)

References 41 publications

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“…Regarding HNSCC, TSR has been studied in oral cancer. Stroma‐rich early stage oral SCCs show worse prognosis than stroma poor carcinomas . These tumors comprise almost 30% of oral cancers, which is in line with our results finding stroma‐rich tumors in almost 23% of non‐oral SCCs.…”

Section: Discussionsupporting

confidence: 91%

“…Stroma‐rich early stage oral SCCs show worse prognosis than stroma poor carcinomas . These tumors comprise almost 30% of oral cancers, which is in line with our results finding stroma‐rich tumors in almost 23% of non‐oral SCCs. Similarly, TSR is a prognostic factor for nasopharyngeal and esophageal SCC .…”

Section: Discussionsupporting

confidence: 91%

“…In 10 HPFs, low BA is 1‐14 and high BA if ≥15 budding nests are found . TSR (Figure ) is evaluated by scanning (×40) the whole tumor sections to select the field with the highest amount of stroma, and then in higher magnification (×100) the selected field is score as stroma‐poor (<50%) or stroma‐rich (≥50%) . Then, this field and independent of its stroma amount is classified as fibroblastic when a loose connective tissue is found or as fibrotic when a dense homogeneous collagenous stroma is found stained yellow due to the saffron stain (Figure ).…”

Section: Methodsmentioning

confidence: 99%

“…Similarly, the stroma could be fibroblastic when composed of loose connective tissue or more fibrotic when a dense homogeneous collagenous stroma is found, while the size of tumor cell nests which are defined as clusters of tumor cells surrounded by stroma can also be important prognostic parameters. These factors have shown important prognostic significance in various forms of cancer, like colorectal, breast, and lung carcinomas, and from HNSCC, only in oral cancer …”

Section: Introductionmentioning

confidence: 99%

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Prognostic significance of tumor budding, tumor‐stroma ratio, cell nests size, and stroma type in laryngeal and pharyngeal squamous cell carcinomas

et al. 2019

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Background Despite immune microenvironment of head and neck squamous cell carcinoma (HNSCC) has been studied, there are no sufficient data on the role of tumor stroma factors. The aim of the study was to explore the prognostic and predictive role of these factors in a large series of HNSCC. Methods This is a retrospective study of 266 patients with laryngeal and pharyngeal SCC. Clinical data were correlated with the following histological parameters: tumor‐stroma ratio (TSR), tumor budding activity (BA), cell nests size (CNS), and stroma type. Results Stroma‐rich tumors, tumor budding, smaller CNS at core and front area, and fibroblastic stroma type, were all adverse prognostic factors (P < 0.0001, 0.001, 0.003, 0.001, 0.007, respectively). Stroma‐poor tumors and with larger CNS showed good response to induction chemotherapy (P = 0.009 and 0.02, respectively). Conclusions TSR, tumor budding, CNS, and stroma type are important prognostic and predictive factors in laryngeal and pharyngeal SCC.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic significance of tumor budding, tumor‐stroma ratio, cell nests size, and stroma type in laryngeal and pharyngeal squamous cell carcinomas

et al. 2019

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“…Overall, a symbiosis between cancer cells and stromal cells in the microenvironment of OSCC was established. Although our current study only reflected the physiologic condition of the stroma‐poor tumor (49), a novel role of TMVs was presented. TMVs allowed tumor cells to regulate the glycometabolic reprogramming in the surrounding stromal cells to create a microenvironment conducive to tumor survival.…”

Section: Discussionmentioning

confidence: 99%

Tumoral microvesicle–activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma

Jiang

Wang

et al. 2019

FASEB j.

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Metabolic reprogramming is a hallmark of cancer. Stromal cells could function as providers of energy metabolites for tumor cells by undergoing the “reverse Warburg effect,” but the mechanism has not been fully elucidated. The interaction between the tumoral microvesicles (TMVs) and stroma in the tumor microenvironment plays a critical role in facilitating cancer progression. In this study, we demonstrated a novel mechanism for the TMV‐mediated glycometabolic reprogramming of stromal cells. After being incubated with TMVs, normal human gingival fibroblasts exhibited a phenotype switch to cancer‐associated fibroblasts and underwent a degradation of caveolin 1 (CAV1) through the ERKl/2‐activation pathway. CAV1 degradation further induced the metabolic switch to aerobic glycolysis in the fibroblasts. The microvesicle‐activated fibroblasts absorbed more glucose and produced more lactate. The migration and invasion of oral squamous cell carcinoma (OSCC) were promoted after being cocultured with the activated fibroblasts. Fibroblast–cancer cell glycometabolic coupling ring mediated by monocarboxylate transporter (MCT) 4 and MCT1 was then proved in the tumor microenvironment. Results indicated a mechanism for tumor progression by the crosstalk between tumor cells and stromal cells through the reverse Warburg effect via TMVs, thereby identifying potential targets for OSCC prevention and treatment.—Jiang, E., Xu, Z., Wang, M., Yan, T., Huang, C, Zhou, X., Liu, Q., Wang, L., Chen, Y., Wang, H., Liu, K., Shao, Z., Shang, Z. Tumoral microvesicle–activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma. FASEB J. 33, 5690–5703 (2019). http://www.fasebj.org

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Presentation, Diagnosis and Prognosis of Squamous Cell Carcinomas of the Oral Mucosa and Oropharynx

Thavaraj,

Jones

2024

Pathological Basis of Oral and Maxillofacial Diseases

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Prognostic impact of tumour–stroma ratio in early‐stage oral tongue cancers

Abstract: We conclude that TSR is a simple histopathological feature that is useful for prognostication of early-stage OTSCC, and suggest that TSR analyses in association with BD score could be included in routine clinical pathology reports for HE-stained slides.

Cited by 60 publications

References 41 publications

Prognostic significance of tumor budding, tumor‐stroma ratio, cell nests size, and stroma type in laryngeal and pharyngeal squamous cell carcinomas

Prognostic significance of tumor budding, tumor‐stroma ratio, cell nests size, and stroma type in laryngeal and pharyngeal squamous cell carcinomas

Tumoral microvesicle–activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma

Presentation, Diagnosis and Prognosis of Squamous Cell Carcinomas of the Oral Mucosa and Oropharynx

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