Prognostic Impacts of Tumour Size on Patients With Primary Cardiac Sarcoma

Guan, Tianwang; Zhang, Hanbin; Lin, Wenrui; Qiu, Zicong; Yang, Jinming; Su, Miao; Lai, Yanxian; Li, Yanfang; Liu, Cheng

doi:10.1016/j.cjca.2019.11.033

Cited by 2 publications

(5 citation statements)

References 27 publications

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“…Nevertheless, a significant strength of our study was the long-term follow-up and multicenter date (18 registries in the US). Although previous studies have reported the adverse prognostic effects of distant metastases in PMCT ( 4 – 6 , 10 ), to the best of our knowledge, this is the first and largest comprehensive analysis of metastatic patterns of patients with PMCT and their prognostic effects.…”

Section: Discussionmentioning

confidence: 97%

“…Previous studies showed that distant metastases were associated with worse OS and CSS in PMCT, but the prognostic effects of different metastatic patterns were not explored ( 5 , 6 , 10 ). Our study revealed that brain metastases were the most lethal among the four metastases sites in PMCT.…”

Section: Discussionmentioning

confidence: 99%

“…The following SEER variables were collected: distant metastases (yes/no), age at diagnosis (≤ 65 years, > 65 years) ( 14 ), sex (male/female), median household income (< 35,000 dollars, 35,000—49,999 dollars, 50,000—74,999 dollars, ≥ 75,000 dollars), year of diagnosis (2010—2013, 2014—2017), race (White, Black, and others), histopathology (lymphomas, sarcomas, mesotheliomas, and others) ( 2 , 5 ), grade (low, high, others, or unknown) ( 5 ), tumor size (≤ 4 cm, > 4 cm) ( 6 ), and surgery (yes, no, or unknown). Due to the lack of data on comorbidities, radiation therapy, and chemotherapy in SEER, we didn’t include these variables as the previous studies ( 15 , 16 ).…”

Section: Methodsmentioning

confidence: 99%

“…Most studies have focused on the characteristics and survival of patients suffering from PMCT (1,2,(7)(8)(9). Although some studies have highlighted the adverse prognostic effects of distant metastases in PMCT and primary cardiac sarcomas (4)(5)(6)10), none of the studies have explored the metastatic rate and distribution of metastases, not to mention the prognostic significance of different metastases patterns in PMCT. Thus, there is a lack of thorough and systematic analysis of metastases patterns in PMCT.…”

Section: Introductionmentioning

confidence: 99%

“…Many patients with PMCT have limited options for curative measures due to metastases and suffer from consequent metastatic complications that might even result in death ( 3 , 4 ). Previous studies identified distant metastases as a prognostic risk factor for PMCT ( 5 , 6 ), thus emphasizing the need for further exploration of metastatic patterns and their related prognostic outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Metastatic patterns and prognosis of patients with primary malignant cardiac tumor

Guan

Wei

Tang

et al. 2022

Front. Cardiovasc. Med.

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BackgroundDistant metastases are independent negative prognostic factors for patients with primary malignant cardiac tumors (PMCT). This study aims to further investigate metastatic patterns and their prognostic effects in patients with PMCT.Materials and methodsThis multicenter retrospective study included 218 patients with PMCT diagnosed between 2010 and 2017 from Surveillance, Epidemiology, and End Results (SEER) database. Logistic regression was utilized to identify metastatic risk factors. A Chi-square test was performed to assess the metastatic rate. Kaplan–Meier methods and Cox regression analysis were used to analyze the prognostic effects of metastatic patterns.ResultsSarcoma (p = 0.002) and tumor size¿4 cm (p = 0.006) were independent risk factors of distant metastases in patients with PMCT. Single lung metastasis (about 34%) was the most common of all metastatic patterns, and lung metastases occurred more frequently (17.9%) than bone, liver, and brain. Brain metastases had worst overall survival (OS) and cancer-specific survival (CSS) among other metastases, like lung, bone, liver, and brain (OS: HR = 3.20, 95% CI: 1.02–10.00, p = 0.046; CSS: HR = 3.53, 95% CI: 1.09–11.47, p = 0.036).ConclusionPatients with PMCT who had sarcoma or a tumor larger than 4 cm had a higher risk of distant metastases. Lung was the most common metastatic site, and brain metastases had worst survival among others, such as lung, bone, liver, and brain. The results of this study provide insight for early detection, diagnosis, and treatment of distant metastases associated with PMCT.

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Section: Discussionmentioning

confidence: 97%