2021
DOI: 10.3389/fcvm.2021.618816
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Prognostic Implication of Liver Function Tests in Heart Failure With Preserved Ejection Fraction Without Chronic Hepatic Diseases: Insight From TOPCAT Trial

Abstract: Background: Liver dysfunction is prevalent in patients with heart failure (HF), but the prognostic significance of liver function tests (LFTs) remains controversial. Heart failure with preserved ejection fraction (HFpEF) had been introduced for some time, but no previous study had focused on LFTs in HFpEF. Thus, we aim to evaluate the prognostic significance of LFTs in well-defined HFpEF patients.Methods and Results: We conveyed a post-hoc analysis of the Treatment of Preserved Cardiac Function Heart Failure w… Show more

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Cited by 17 publications
(25 citation statements)
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“…The only abnormality in the biochemical parameters of the liver function was the increased AST/ALT ratio in pigs with severe HF indicating the hepatocellular damage, consistent with the histopathological findings. In human HF, the prognostic values of liver function tests have not been established yet, as studies focusing on this issue produce conflicting results [23][24][25].…”
Section: Discussionmentioning
confidence: 99%
“…The only abnormality in the biochemical parameters of the liver function was the increased AST/ALT ratio in pigs with severe HF indicating the hepatocellular damage, consistent with the histopathological findings. In human HF, the prognostic values of liver function tests have not been established yet, as studies focusing on this issue produce conflicting results [23][24][25].…”
Section: Discussionmentioning
confidence: 99%
“…It is also known that patients with chronic heart failure with severe hepatic dysfunction have poor outcomes ( 31 – 33 ). However, others have found that aminotransferase concentrations are not associated with worse clinical outcomes ( 34 , 35 ).…”
Section: Discussionmentioning
confidence: 99%
“… 1 Those with HFpEF, as is the case with our patient, tend to demonstrate cholestatic pattern since there is lower likelihood of hypotension or hypoperfusion in these patients to cause hepatic injury. 6 In patients with HFpEF, and gradually burdening atrial fibrillation, the cardiac output lessens, creating elevated filling pressures that cause pulmonary vascular disease leading to right heart failure. 4 This passive congestion through increased filling pressures causes mildly elevated transaminases, which can be markedly elevated in the setting of hypotension and hepatic ischemia.…”
Section: Discussionmentioning
confidence: 99%