Prognostic Implication of Preoperative Serum Albumin to Carcinoembryonic Antigen Ratio in Colorectal Cancer Patients

Xu, Mingyue; Li, You; Xue, Tianhui; Ye, Qianwen; Xiang, Jia; Liu, Long; Yan, Bing

doi:10.1177/15330338221078645

Cited by 3 publications

(1 citation statement)

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“…Carcinoembryonic antigens were useful prognostic factors in CRC. 13 Compared to solitary CRC, abnormal CEA was more commonly seen in patients with SCRC. 14 Preoperative CEA positivity was a significant predictor of SA for SCRC patients ( P = .047) but was not associated with metachronous lesions ( P = .187, .302, respectively).…”

Section: Discussionmentioning

confidence: 98%

Surveillance Colonoscopies of Synchronous Colorectal Cancer: What Should We Do?

Guo¹,

Wu²,

Wang³

et al. 2023

Turk J Gastroenterol

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Background: The aim of this study is to investigate the occurrence of metachronous neoplasms at 2-year surveillance colonoscopy for synchronous colorectal cancer patients and the relative risk factors. Methods: Synchronous colorectal cancer patients who underwent surgery or endoscopic resection for colorectal cancer between January 2008 and December 2019 were enrolled. All patients underwent surveillance colonoscopies at least twice within 2 years after operation. Univariate and multivariate analyses were conducted to assess the risk factors for the metachronous neoplasms. Results: Totally 38 patients (male/female: 26/12) were included, with an average age of 64.6 years (±11.5 years) and a mean surveillance interval of 23.47 ± 4.39 months. In 21 of 38 patients (55.3%), metachronous adenoma was detected, including 6 metachronous advanced adenomas. Two patients were detected with metachronous carcinomas. In univariate analysis, male sex, elderly age at diagnosis, and the presence of synchronous adenomas/synchronous advanced adenoma at baseline colonoscopy were associated with the development of metachronous adenoma ( P = .037, .047, .013, .039), but not associated with metachronous advanced adenoma ( P = 0.455, .746, .503, .269). Patients tends to occur less metachronous advanced adenoma if index colorectal tumors were treated by endoscopic resection ( P = .010), but the tendency was not discovered in metachronous adenoma ( P = .289). Tumor location (with/without rectum cancer) was not associated with the development of metachronous lesions ( P = .526, .382). On multivariate analysis, the presence of synchronous adenomas at baseline colonoscopy was an independent risk factor for MA during follow-up (odds ratio = 15.0; 95% CI: 1.55-145.22). Conclusion: For postoperative synchronous colorectal cancer patients, doctors should design individual surveillance strategies according to sex, baseline colonoscopy, and operative (or endoscopic) approach of resection.

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Section: Discussionmentioning

confidence: 98%

Surveillance Colonoscopies of Synchronous Colorectal Cancer: What Should We Do?

Guo¹,

Wu²,

Wang³

et al. 2023

Turk J Gastroenterol

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A combined nutritional risk index and carcinoembryonic antigen score predicts the outcome in radically resected colorectal cancer

Chen,

Xie,

et al. 2024

ANZ Journal of Surgery

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BackgroundNutritional risk index (NRI) and carcinoembryonic antigen (CEA) are useful prognostic markers in colorectal cancer (CRC); however, the prognostic value of a combination of the NRI and CEA, namely, the NRI and CEA score (NCS), needs further investigation.MethodsStage I‐III CRC patients were collected and then divided into three subgroups by counting the NCS: NCS 1: high NRI with normal CEA; NCS 2: high NRI with elevated CEA or low NRI with normal CEA; and NCS 3: low NRI with elevated CEA. The differences in outcome, counted as disease‐free survival (DFS) and overall survival (OS), were tested among the subgroups.ResultsA total of 285 patients were enrolled, with 108 in NCS 1, 118 in NCS 2 and 59 in NCS 3. Patient features, including age, tumour deposit, T stage, N stage and TNM stage, were significantly different in the NCS subgroups. Both the DFS (log‐rank = 26.06, P<0.001) and OS (log‐rank = 39.10, P<0.001) were significant in different NCS subgroups, even in maximum tumour diameter ≤4 cm cases (DFS: log‐rank = 21.42, P<0.001; OS: log‐rank = 30.95, P<0.001), and NCS 1 patients displayed the best outcome compared with the rest of the subgroups. NCS was also found to be an independent risk factor for both DFS and OS.ConclusionsNCS was a useful prognostic indicator in stages I–III CRC patients.

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