Prognostic Implications of Asymptomatic Ventricular Arrhythmias: The Framingham Heart Study

Bikkina, Mahesh

doi:10.7326/0003-4819-117-12-990

Cited by 222 publications

(122 citation statements)

References 41 publications

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“…But no significant difference was found in these parameters between the groups. However, this finding does not support other similar studies [22][23][24] . Many longitudinal studies have shown that TAG level increases with transition through the menopause and the increase in TAG also appears early in the postmenopausal period.…”

Section: Discussioncontrasting

confidence: 99%

Comparison of Atherogenic Index of Plasma (AIP) Between Postmenopausal Women with Central Obesity and Postmenopausal Nonobese Women

Khanam

Khan²,

Rahman

et al. 2014

Chatt Maa Shi Hosp Med Coll J

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Background: Following menopause there are changes in values of lipid profile parameters. Abdominal obesity has also been linked to significant metabolic abnormalities including changes in lipid parameter values. Atherogenic index of plasma (AIP) calculated as log (TG/HDL-C) has been used as some practitioners as a significant predictor of atherosclerosis. So, we designed this study to observe the pattern of lipid profile parameters and to find out AIP in postmenopausal central obese women and to compare these between postmenopausal women with central obesity and postmenopausal nonobese women. Objectives: To assess the lipid profile status and AIP of postmenopausal women with central obesity and to compare these parameters with that of postmenopausal nonobese women. Materials & Methods: This cross sectional study was carried out in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Sixty six postmenopausal women with central obesity and age matched 56 nonobese postmenopausal women were included in the study. Central obesity was defined having waist hip ratio more than 0.8 and BMI <25.0. All statistical analyses were done by SPSS 18.0. p values <0.05 were considered significant. Results: Statistically no significant difference was observed between the central obese women and nonobese women in lipid profile parameters. But AIP was found significantly higher in postmenopausal central obese women. Conclusion: Central obese postmenopausal women may be at higher risk of cardiovascular events compared with postmenopausal nonobese women in spite of no difference in lipid profile parameters as their AIP values are significantly different.

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Section: Discussioncontrasting

confidence: 99%

Comparison of Atherogenic Index of Plasma (AIP) Between Postmenopausal Women with Central Obesity and Postmenopausal Nonobese Women

Khanam

Khan²,

Rahman

et al. 2014

Chatt Maa Shi Hosp Med Coll J

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“…Therefore, we further categorized EVPBs as high grade if one or more of the following were present (Lown criteria), consistent with prior reports: 5,18 frequency Ͼ30/h, multiform, couplets, and nonsustained (Ն3 consecutive VPBs lasting Ͻ30 seconds) or sustained ventricular tachycardia. In the absence of these features, EVPBs were labeled low grade.…”

Section: Definitions Of 'Frequent' Evpbs and Their Gradementioning

confidence: 83%

Clinical Correlates and Prognostic Significance of Exercise-Induced Ventricular Premature Beats in the Community

Morshedi-Meibodi¹,

Evans²,

Levy³

et al. 2004

Circulation

107

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Background-Recent investigations suggest that ventricular premature beats during exercise (EVPBs) are associated with increased cardiovascular mortality in asymptomatic individuals, but mechanisms underlying the association are unclear. Method and Results-We evaluated 2885 Framingham Offspring Study participants (1397 men; mean age, 43 years) who were free of cardiovascular disease and who underwent a routine exercise stress test; 792 participants (27%) had development of EVPBs (median, 0.22/min of exercise). Logistic regression was used to evaluate predictors of EVPBs. Cox models were used to examine the relations of infrequent (less than or equal to median) and frequent (greater than median) versus no EVPBs to incidence of hard coronary heart disease (CHD) event (recognized myocardial infarction, coronary insufficiency, or CHD death) and all-cause mortality, adjusting for vascular risk factors and exercise variables. Age and male sex were key correlates of EVPBs. During follow-up (mean, 15 years), 142 (113 men) had a first hard CHD event and 171 participants (109 men) died. EVPBs were not associated with hard CHD events but were associated with increased all-cause mortality rates (multivariable-adjusted hazards ratio, 1.86, 95% CI, 1.24 to 2.79 for infrequent, and 1.71, 95% CI, 1.18 to 2.49 for frequent EVPBs versus none). The relations of EVPBs to mortality risk were not influenced by VPB grade, presence of recovery VPBs, left ventricular dysfunction, or an ischemic ST-segment response. Conclusions-In our large, community-based sample of asymptomatic individuals, EVPBs were associated with increased risk of death at a much lower threshold than previously reported. Additional studies are needed to confirm these findings and to clarify the underlying mechanisms.

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“…During a 12-month follow-up period despite the patient remained symptom free with no ventricular arrhythmia on Holter monitor and ICD interrogation, he had no reversal of depressed systolic function. data suggesting that the presence of more than 30 PVCs per hour, PVC couplet, or the presence of R on T have been associated with a small absolute but statistically significant two-fold increase in mortality [9] . As frequent VPCs can be a part of a structural heart disease, and therefore frequent VPCs are a cause of cardiomyopathy.…”

Section: Casementioning

confidence: 95%

Frequent Premature Ventricular Contractions and Cardiomyopathy, Chicken and Egg situation

Yalın

Gölcük

2017

Journal of Atrial Fibrillation

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Prognostic Implications of Asymptomatic Ventricular Arrhythmias: The Framingham Heart Study

Cited by 222 publications

References 41 publications

Comparison of Atherogenic Index of Plasma (AIP) Between Postmenopausal Women with Central Obesity and Postmenopausal Nonobese Women

Comparison of Atherogenic Index of Plasma (AIP) Between Postmenopausal Women with Central Obesity and Postmenopausal Nonobese Women

Clinical Correlates and Prognostic Significance of Exercise-Induced Ventricular Premature Beats in the Community

Frequent Premature Ventricular Contractions and Cardiomyopathy, Chicken and Egg situation

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