Precision Medicine in Oncology 2020
DOI: 10.1002/9781119432487.ch4
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Prognostic Implications of EGFR, p53, p16, Cyclin D1, and Bcl‐2 in Head and Neck Squamous Cell Carcinoma (HNSCC)

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Cited by 2 publications
(2 citation statements)
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“…73 Moreover, it has been claimed that the over-expression in the EGFR gene not only resulted in the advanced stage of the disease 74,75 but also negatively affected the response rate of HNSCC cells to surgery, chemotherapy, and radiation. 76 In an interesting study, the results of high-F I G U R E 2 A summary of mutations in the EGFR and components of the PI3K/Akt/ mTOR pathway in HNSCC. Thus far, several genetic alteration in different components of the PI3K/Akt signaling axis in HNSCC patients has been identified.…”
Section: Hnscc In a Prospective Of Genetic Alterations In The Pi3k Axismentioning
confidence: 99%
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“…73 Moreover, it has been claimed that the over-expression in the EGFR gene not only resulted in the advanced stage of the disease 74,75 but also negatively affected the response rate of HNSCC cells to surgery, chemotherapy, and radiation. 76 In an interesting study, the results of high-F I G U R E 2 A summary of mutations in the EGFR and components of the PI3K/Akt/ mTOR pathway in HNSCC. Thus far, several genetic alteration in different components of the PI3K/Akt signaling axis in HNSCC patients has been identified.…”
Section: Hnscc In a Prospective Of Genetic Alterations In The Pi3k Axismentioning
confidence: 99%
“…Chung et al revealed that those HNSCC patients who were positive for EGFR gene amplification had worse progression‐free and overall survival 73 . Moreover, it has been claimed that the over‐expression in the EGFR gene not only resulted in the advanced stage of the disease 74,75 but also negatively affected the response rate of HNSCC cells to surgery, chemotherapy, and radiation 76 . In an interesting study, the results of high‐resolution global copy number and mutational analysis of the EGFR pathway revealed that some other mediatory proteins that are involved in the regulation of this protein, such as protein tyrosine phosphatase receptor S (PTPRS) could also undergo genetic alterations.…”
Section: Hnscc In a Prospective Of Genetic Alterations In The Pi3k Axismentioning
confidence: 99%