Prognostic implications of epidermal growth factor receptor immunoreactivity in squamous cell carcinoma of the oral mucosa

Maiorano, Eugenio; Maisonneuve, Patrick; Viale, Giuseppe

doi:10.1002/(sici)1096-9896(199806)185:2<167::aid-path70>3.0.co;2-e

Cited by 41 publications

(12 citation statements)

References 43 publications

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“…Despite this, reports of EGFR being a favourable prognostic factor are rare. In this regard a study in oral carcinoma that demonstrated membranous EGFR expression to be associated with a favourable outcome similar to MM is noteworthy [40].…”

Section: Discussionmentioning

confidence: 97%

EGFR expression: Associations with outcome and clinicopathological variables in malignant pleural mesothelioma

et al. 2006

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Section: Discussionmentioning

confidence: 97%

EGFR expression: Associations with outcome and clinicopathological variables in malignant pleural mesothelioma

et al. 2006

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“…To our knowledge, this is the first report of EGFR subcellular location as a prognostic factor in OSCC using TMA technology. Although only a few studies so far have investigated the cellular distribution of this receptor (39,40), this determination seems to us as practical, easy and objective.…”

Section: Discussionmentioning

confidence: 99%

Combined cytoplasmic and membranous EGFR and p53 overexpression is a poor prognostic marker in early stage oral squamous cell carcinoma

Monteiro¹,

Diniz‐Freitas

García‐Caballero

et al. 2012

J Oral Pathology Medicine

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“…For example, ET-1-induces prostaglandin-E 2 (PGE 2 ) production in ovarian carcinoma cell lines (Spinella et al, 2004). Interestingly, this is mediated through the epidermal growth factor receptor (EGFR) which is significantly upregulated in oral SCC (Grandis et al, 1998;Maiorano et al, 1998). The production of PGE 2 might contribute to cancer pain in humans; however, it is unlikely the sole cause of cancer pain (Mercadante and Portenoy, 2001;Sorge, 2000).…”

Section: Discussionmentioning

confidence: 99%

Peripheral endothelin A receptor antagonism attenuates carcinoma‐induced pain

Schmidt¹,

Pickering²,

Liu³

et al. 2007

European Journal of Pain

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In this study we investigated the role of endothelin-1 (ET-1) and its peripheral receptor (ET-A) in carcinoma-induced pain in a mouse cancer pain model. Tumors were induced in the hind paw of female mice by local injection of cells derived from a human oral squamous cell carcinoma (SCC). Significant pain, as indicated by reduction in withdrawal thresholds in response to mechanical stimulation, began at four days after SCC inoculation and lasted to 28 days, the last day of measurement. Intra-tumor expression of both ET-1 mRNA and ET-1 protein were significantly upregulated compared to normal tissue, and local administration of the ET-A receptor selective antagonist, BQ-123 (100 microM) significantly elevated withdrawal thresholds, indicating the induction of an antinociceptive effect. These findings support the suggestion that ET-1 and ET-A receptors contribute to the severity of carcinoma-induced soft tissue cancer pain.

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Prognostic implications of epidermal growth factor receptor immunoreactivity in squamous cell carcinoma of the oral mucosa

Cited by 41 publications

References 43 publications

EGFR expression: Associations with outcome and clinicopathological variables in malignant pleural mesothelioma

EGFR expression: Associations with outcome and clinicopathological variables in malignant pleural mesothelioma

Combined cytoplasmic and membranous EGFR and p53 overexpression is a poor prognostic marker in early stage oral squamous cell carcinoma

Peripheral endothelin A receptor antagonism attenuates carcinoma‐induced pain

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