Prognostic implications of histological organ involvement in retroperitoneal sarcoma

Tyler, Robert; Lee, M; Ierodiakonou, V; Hodson, James; Tanière, Philippe; Almond, Max; Ford, Samuel J.; Desai, Anant

doi:10.1093/bjsopen/zrab080

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…For example, E. Nizri et al reported that intraperitoneal invasion was associated with increased LR and decreased survival, and Tyler et al reported that histologic organ involvement was associated with shorter OS. [ 24 , 25 ]. No additional prognostic factors for RPS were identified in the current study.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Effect of Tumor-Grade Change on the Prognosis of Retroperitoneal Sarcoma

Kim

Lim

et al. 2022

Cancers

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In retroperitoneal sarcoma (RPS), the change in the tumor grade from the primary tumor to the first local recurrence, and the effect of this change on prognosis, are unknown. The aim of this study is to analyze whether these changes affect the prognosis of RPS. Patients who underwent surgery for a first locally recurrent RPS at Samsung Medical Center from January 2001 to February 2020 were included. The pathologic features of primary and recurrent tumors were compared, and the outcomes were measured. A total of 49 patients were investigated. There were 25 patients with different grades of primary and recurrent tumors. The improving, stable, and worsening groups contained 16 (32.7%), 24 (49%), and 9 (18.3%) patients, respectively. There was no significant difference in the prognosis between the three groups. In the analyses of the factors that affect the OS, a high grade of the primary tumor (p = 0.023) and the size of the recurrent tumor (p = 0.032) were statistically significant in both univariate and multivariate analyses. In a factor analysis of the second LR, a high-grade recurrent tumor (p = 0.032) was the only significant factor. There were tumor-grade changes between the primary tumor and recurrent tumor in RPS. However, the most important factor in prognosis is a high grade of the primary tumor.

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Section: Discussionmentioning

confidence: 99%

Analysis of the Effect of Tumor-Grade Change on the Prognosis of Retroperitoneal Sarcoma

Kim

Lim

et al. 2022

Cancers

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“…HOI is frequently observed following surgery for retroperitoneal liposarcomas. HOI stratifies the prognostic risk of patients with retroperitoneal leiomyosarcomas [37], while ongoing debate questions this association in well differentiated (WDLPS) and de-differentiated liposarcoma (DDLPS). A recent study found that the degree of HOI is an independent predictive factor for OS and DFS (Table 2).…”

Section: How To Improve Further Prognostication Of All Sarcomas: Inte...mentioning

confidence: 99%

Sarculator: how to improve further prognostication of all sarcomas

Borghi,

Gronchi

2024

Current Opinion in Oncology

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Purpose of review Prognostication of soft tissue sarcomas is challenging due to the diversity of prognostic factors, compounded by the rarity of these tumors. Nomograms are useful predictive tools that assess multiple variables simultaneously, providing estimates of individual likelihoods of specific outcomes at defined time points. Although these models show promising predictive ability, their use underscores the need for further methodological refinement to address gaps in prognosis accuracy. Recent findings Ongoing efforts focus on improving prognostic tools by either enhancing existing models based on established parameters or integrating novel prognostic markers, such as radiomics, genomic, proteomic, and immunologic factors. Artificial intelligence is a new field that is starting to be explored, as it has the capacity to combine and analyze vast and intricate amounts of relevant data, ranging from multiomics information to real-time patient outcomes. Summary The integration of these innovative markers and methods could enhance the prognostic ability of nomograms such as Sarculator and ultimately enable more accurate and individualized healthcare. Currently, clinical variables continue to be the most significant and effective factors in terms of predicting outcomes in patients with STS. This review firstly introduces the rationale for developing and employing nomograms such as Sarculator, secondly, reflects on some of the latest and ongoing methodological refinements, and provides future perspectives in the field of prognostication of sarcomas.

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“…Several studies have investigated the frequency of microscopic infiltration in resected organs in an attempt to help guide surgical decision making [36,37]. These data are inherently biased in that only resected tissue is available for study and the level of pathologic assessment is not standardized.…”

Section: Surgical Approachmentioning

confidence: 99%

Surgical Management of Retroperitoneal Sarcoma

et al. 2023

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Surgery is the cornerstone of treatment for retroperitoneal sarcoma (RPS). Surgery should be performed by a surgical oncologist with sub-specialization in this disease and in the context of a multidisciplinary team of sarcoma specialists. For primary RPS, the goal of surgery is to achieve the complete en bloc resection of the tumor along with involved organs and structures to maximize the clearance of the disease. The extent of resection also needs to consider the risk of complications. Unfortunately, the overarching challenge in primary RPS treatment is that even with optimal surgery, tumor recurrence occurs frequently. The pattern of recurrence after surgery (e.g., local versus distant) is strongly associated with the specific histologic type of RPS. Radiation and systemic therapy may improve outcomes in RPS and there is emerging data studying the benefit of non-surgical treatments in primary disease. Topics in need of further investigation include criteria for unresectability and management of locally recurrent disease. Moving forward, global collaboration among RPS specialists will be key for continuing to advance our understanding of this disease and find more effective treatments.

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Prognostic implications of histological organ involvement in retroperitoneal sarcoma

Cited by 8 publications

References 22 publications

Analysis of the Effect of Tumor-Grade Change on the Prognosis of Retroperitoneal Sarcoma

Analysis of the Effect of Tumor-Grade Change on the Prognosis of Retroperitoneal Sarcoma

Sarculator: how to improve further prognostication of all sarcomas

Surgical Management of Retroperitoneal Sarcoma

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