Prognostic Implications of Left Atrial Enlargement in Degenerative Mitral Regurgitation

Essayagh, Benjamin; Antoine, Clémence; Benfari, Giovanni; Messika–Zeitoun, David; Michelena, Héctor I.; Tourneau, Thierry Le; Mankad, Sunil; Tribouilloy, Christophe; Thapa, Prabin; Enríquez-Sarano, Maurice

doi:10.1016/j.jacc.2019.06.032

Cited by 69 publications

(57 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LA enlargement is basically a marker of volume overload in both primary and secondary MR and of increased filling pressures in secondary MR. 3 In patients with degenerative MR, LA enlargement is associated with long-term mortality when treated conservatively or surgically, and this was independent of other risk factors such as atrial fibrillation. 4 Importantly, the risk association was independent of the severity of MR indicating a mechanism beyond pure volume overload. As such, significant LA dilatation is a class IIa indication for surgery in degenerative MR. 5 In patients with heart failure with preserved or reduced ejection fraction, LA enlargement is a strong and independent predictor of mortality and disease progression.…”

Section: Introductionmentioning

confidence: 95%

“…LA enlargement is basically a marker of volume overload in both primary and secondary MR and of increased filling pressures in secondary MR . In patients with degenerative MR, LA enlargement is associated with long‐term mortality when treated conservatively or surgically, and this was independent of other risk factors such as atrial fibrillation . Importantly, the risk association was independent of the severity of MR indicating a mechanism beyond pure volume overload.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of left atrial diameter on outcome in patients undergoing edge‐to‐edge mitral valve repair: results from the German TRAnscatheter Mitral valve Interventions (TRAMI) registry

Iliadis

Baldus

Kalbacher

et al. 2020

European J of Heart Fail

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Impact of left atrial diameter on outcome in patients undergoing edge‐to‐edge mitral valve repair: results from the German TRAnscatheter Mitral valve Interventions (TRAMI) registry

Iliadis

Baldus

Kalbacher

et al. 2020

European J of Heart Fail

View full text Add to dashboard Cite

show abstract

“…The nomogram is prediction, so the decision curve analysis method (DCA) is to solve the clinical utility problem and solve the clinical practicality of the nomogram. Now it is also widely used in various fields, such as predicting the prognosis of lung cancer [33], sentinel lymph node metastasis of skin melanoma [34], The prognosis of left atrial enlargement in degenerative mitral regurgitation [35]. In this study, after adding the risk score signature, patients benefited more from 1-, 2-, 3-years.…”

Section: Discussionmentioning

confidence: 86%

Identification and Validation of Autophaggen-based Nomograms to Predict the Prognostic Value of Patients with Cervical Cancer

Jiang¹,

Xu²,

Zhao³

et al. 2020

Preprint

View full text Add to dashboard Cite

Cervical cancer is a common malignancy in women and has a poor prognosis.More and more studies have shown that autophagy disorder is closely related to the occurrence of tumors. However, the prognostic role of autophagy gene in cervical cancer is still unclear. In this study, we constructed the risk signatures of autophagy related genes to predict the prognosis of cervical cancer. The expression profiles and clinical information of autophagy gene sets were downloaded from the TCGA and GES52903 queues as training sets and validation sets. The cervical normal tissue expression profile data from UCSC XENA website is GTEx data as a supplement to TCGA normal cervical tissue. Univariate COX regression analysis of 17 different autophagy genes with the Consensus approach tumor samples from the TCGA is divided into six subtypes, and the clinical traits in the six subtypes have different distribution, with further then absolute shrinkage and selection operator (LASSO) and multiariable COX regression method finally got seven autophagy genetic risk model is constructed, in the training set, the survival rate of high risk group is lower than the low risk group (p < 0.0001), the validation set,The AUC area of the receiver operating characteristic (ROC) curve, the training set is 0.894, and the verification set is 0.736. We find that the high and low risk score is closely related to the TMN stage (All P is less than 0.05).The nomogram shows that the risk score combined with other indicators such as age, G,T,M, and N better predicts 1-year, 2-year, 3-year survival, and the DCA curve shows that the risk model combined with other indicators produces better clinical efficacy.Then immune cells in 28 in the enrichment score, there were statistically significant differences, high and low risk most GSEA enrichment analysis, the main enrichment in G2 / M checkpoint high-risk score, Genes defining epithelial and mesenchymal transition, raised in response to the low oxygen levels (hypoxia) gene, gene is important to the mitotic spindle assembly, these are closely related with the occurrence of tumor . In conclusion, our constructed autophagy risk signature may be a prognostic tool for cervical cancer.

show abstract

“…In this context, along with comorbidities and risk factors, any degree of both primary and secondary MR represents a potential determinant of LA remodelling and the combination of both significantly increases the risk of adverse events even before symptom onset and regardless of LV function and severity of valve abnormalities 18,19 . Also, the excess risk of mortality is partially attenuated by treatment when LA remodelling is advanced 20 . The mechanisms modulating LA impairment in response to MR are not well understood.…”

Section: Figurementioning

confidence: 99%

Mitral regurgitation, edge‐to‐edge valve repair and the left atrium: one step beyond the left ventricle?

Rossi

2020

European J of Heart Fail

View full text Add to dashboard Cite

show abstract

Prognostic Implications of Left Atrial Enlargement in Degenerative Mitral Regurgitation

Cited by 69 publications

References 38 publications

Impact of left atrial diameter on outcome in patients undergoing edge‐to‐edge mitral valve repair: results from the German TRAnscatheter Mitral valve Interventions (TRAMI) registry

Impact of left atrial diameter on outcome in patients undergoing edge‐to‐edge mitral valve repair: results from the German TRAnscatheter Mitral valve Interventions (TRAMI) registry

Identification and Validation of Autophaggen-based Nomograms to Predict the Prognostic Value of Patients with Cervical Cancer

Mitral regurgitation, edge‐to‐edge valve repair and the left atrium: one step beyond the left ventricle?

Contact Info

Product

Resources

About