Prognostic Implications of Lymph Node Yield and Lymph Node Ratio in Papillary Thyroid Carcinoma

Abstract

The LNR is an important independent prognostic factor in PTC and can be used in conjunction with existing staging systems. A clinical relevant cut-off point of 0.3 (one positive lymph node out of three total) is proposed. No prognostic implications for LNY were identified.

Prognostic value of lymph node ratio in metastatic papillary thyroid carcinoma

“…After critical examination, nine studies were considered adequate according to the inclusion criteria. [18][19][20][21][22][23][24][25][26] These nine studies were published between 2012 and 2016. All studies were retrospective.…”

“…Five out of eight studies [19][20][21][22]24 investigated the effect of central compartment metastases (N 1a ) alone on recurrence. Three of the studies 19,21,22 (60 per cent) Lang et al 20 Schneider et al 21 Ryu et al 22 Chang et al…”

“…17 Multiple recent studies have evaluated the prognostic value of lymph node ratio in papillary thyroid carcinoma regarding loco-regional recurrence and survival, with varying results. [18][19][20][21][22][23][24][25][26] This study aimed to review recent publications addressing the prognostic value of lymph node ratio in metastatic papillary thyroid carcinoma.…”

“…Vas Nunes et al 24 Park et al 25 Lee et al and both central and lateral compartment metastases on recurrence-free survival, respectively. [19][20][21][22][23][24][25][26] Different lymph node ratio thresholds were used in each study (range, 0.3-0.86).…”

“…[19][20][21][22][23][24][25][26] Different lymph node ratio thresholds were used in each study (range, 0.3-0.86). The prognostic values of lymph node ratio and the hazard ratios for loco-regional recurrence are presented in Table II.…”