2011
DOI: 10.1111/j.1464-410x.2011.10330.x
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Prognostic implications of lymph node involvement in bladder cancer: are we understaging using current methods?

Abstract: To review the current and newer, alternative methods for evaluating lymph nodes for tumor involvement in bladder cancer as relapse rates for organ‐confined disease remain high despite improvements in surgical technique, suggesting the possibility of understaging. To propose a research agenda based on these findings. A PubMed literature search was performed to identify studies examining the prognostic implications of and outcomes associated with lymph node involvement in bladder cancer as well as those that uti… Show more

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Cited by 14 publications
(3 citation statements)
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“…Bladder cancer ranks fourth in men and eighth in women among the most common malignancies in terms of frequency (27). However, little progress was made in the past decades toward prolonged survival of high-grade bladder cancer, leaving it still a lethal disease (28).…”
Section: Discussionmentioning
confidence: 99%
“…Bladder cancer ranks fourth in men and eighth in women among the most common malignancies in terms of frequency (27). However, little progress was made in the past decades toward prolonged survival of high-grade bladder cancer, leaving it still a lethal disease (28).…”
Section: Discussionmentioning
confidence: 99%
“…Presently, there are no defined tumor markers available for stratifying patients with respect to disease progression, prognosis or treatment, and no predictors of metastatic potential. Most patients with advanced cancer ultimately succumb to their disease with the most significant prognostic factor being the presence of LN metastasis [4]. While much work has been done on identifying the presence of metastatic tumor cells in LNs [reviewed in Watts el al., [4]], little research currently explores the ability to predict the likelihood of harboring or developing metastasis based on primary tumor characteristics.…”
Section: Introductionmentioning
confidence: 99%
“…The bladder carcinoma (BCa) is the fifth most common cancer, which accounts for 85‐90% of the primary carcinomas with increasing incidence worldwide [1, 2]. Although the research on BCa was advanced rapidly in the last decade, the pathogenesis of BCa remains unknown; the prognosis of patients with BCa is unsatisfactory [3].…”
Section: Introductionmentioning
confidence: 99%