Prognostic implications of mean platelet volume on short- and long-term outcomes among patients with non-ST-segment elevation myocardial infarction treated with percutaneous coronary intervention: A single-center large observational study

Wasilewski, Jarosław; Desperak, Piotr; Hawranek, Michał; Ciślak, Aneta; Osadnik, Tadeusz; Pyka, Łukasz; Gawlita, Marcin; Bujak, Kamil; Niedziela, Jacek; Krawczyk, Michał; Gąsior, Mariusz

doi:10.3109/09537104.2016.1143919

Cited by 40 publications

(42 citation statements)

References 30 publications

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“…Platelet volume indices are indicator of platelet activation and play an important role in the pathophysiology of cardiovascular diseases 16, 17. In the study, we found that patients with OSA have higher MPV and platelet large cell ratio values (Figure 1A and 1B).…”

Section: Resultsmentioning

confidence: 76%

“…Recently, Wasilewski et al have reported that all‐cause mortality is 1.5‐fold higher in non‐ST‐segment elevation myocardial infarction patients with high MPV values 17. In earlier studies, MPV and PDW were found to be significantly higher in patients with severe OSA when compared with control subjects 23, 24.…”

Section: Discussionmentioning

confidence: 93%

“…Platelet volume indices are known as indicators of platelet activation and play an important role in the pathophysiology of cardiovascular diseases 16, 17. Recently, Wasilewski et al have reported that all‐cause mortality is 1.5‐fold higher in non‐ST‐segment elevation myocardial infarction patients with high MPV values 17.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Obstructive Sleep Apnea on Platelet Function Profiles in Patients With Acute Coronary Syndrome Taking Dual Antiplatelet Therapy

Gong

Xiao

Fan

et al. 2018

JAHA

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BackgroundObstructive sleep apnea (OSA) is a novel risk factor for acute coronary syndrome (ACS). Several studies have shown OSA to be associated with induced platelet reactivity. However, whether OSA have effects on platelet function profiles in ACS patients taking dual antiplatelet therapy remains unexplored.Methods and ResultsThis was a cross‐sectional observational study, in which ACS patients taking maintenance aspirin and clopidogrel therapy were included. OSA was defined as an apnea‐hypopnea index ≥15 events/hour. The inhibitory rate of arachidonic acid or adenosine diphosphate pathway were assessed with thrombelastography and defined patients with high residual on‐treatment platelet reactivity. Platelet indices were obtained from routine analysis of blood samples using an automated blood cell counter. A total of 127 ACS patients taking dual antiplatelet therapy were analyzed. Platelet volume indices, including mean platelet volume and platelet large cell ratio, were significantly increased in patients with OSA. Patients with OSA (n=68) had significantly lower inhibitory rate of adenosine diphosphate receptor pathway (P=0.028) compared with those without (n=59). After adjustment for potential confounders, patients with OSA were more likely to have high residual on‐treatment platelet reactivity after clopidogrel therapy (adjusted odds ratio: 3.25, 95% confidence interval: 1.19–8.87, P=0.021).ConclusionsIn ACS patients taking dual antiplatelet therapy, OSA is associated with an increased level of platelet volume indices, reduced clopidogrel‐induced antiplatelet effects and a greater prevalence of high residual on‐treatment platelet reactivity.

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Section: Resultsmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 93%

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Impact of Obstructive Sleep Apnea on Platelet Function Profiles in Patients With Acute Coronary Syndrome Taking Dual Antiplatelet Therapy

Gong

Xiao

Fan

et al. 2018

JAHA

View full text Add to dashboard Cite

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“…Large platelets have denser granules containing mediators that play a role in inflammation, atherosclerosis, and eventually cardiac syndromes. Higher MPV is associated with increased mortality after both ST segment elevation myocardial infarction (STEMI) and non-STEMI [7,8]. Higher MPV correlates with the reperfusion failure in STEMI [8,9].…”

Section: Discussionmentioning

confidence: 99%

Association of mean platelet volume with presence of non-viable myocardium in ischaemic cardiomyopathy

Öztürk

Gurbuz

Efe³

et al. 2017

Kardiol Pol

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A b s t r a c tBackground: Parameters derived from complete blood count, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have recently been proposed as measures of inflammation in addition to C-reactive protein (CRP), a classical inflammatory marker. Significant association of these parameters with atherosclerosis and complications have increasingly been reported. Aim:The aim of the study is to evaluate the relationship between these parameters and the presence of myocardial viability assessed with positron emission tomography (PET) in patients with ischaemic cardiomyopathy (ICM).Methods: A total of 122 ICM patients who had undergone PET were enrolled in this study. The patients were dichotomised depending on the presence of transmural scar. Group 1 consisted of 21 patients who had transmural scar tissue only, who were accepted as the group having non-viable myocardium. Group 2 consisted of 101 patients who had hibernation and/or non-transmural scar, who were accepted as the group having viable myocardium. Haematological parameters within 30 days of PET imaging were retrospectively analysed.Results: There were no significant differences between the two groups regarding values of white blood cell, neutrophil, lymphocyte, platelet, haemoglobin, red cell distribution width, CRP, PLR, and NLR. Patients with non-viable myocardium have significantly higher levels of MPV (p = 0.002). In multiple logistic regression analysis, MPV (odds ratio [OR] = 0.373, 95% confidence interval [CI] 0.20-0.69, p = 0.002), was identified as an independent predictor of non-viable myocardium. In receiver-operator characteristic (ROC) analysis, a cut-point of 8.19 identified patients with non-viable myocardium (area under curve: 0.72, 95% CI 0.60-0.84). An MPV value greater than 8.19 demonstrated a sensitivity of 76% and a specificity of 55%. Conclusions:The present study showed that MPV is an inexpensive, clinical, and routinely measurable parameter that is associated with the presence of viable myocardium in ICM.

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“…[29,31]. После публикации последне-го метаанализа в 2015 г. появилось еще не-сколько работ, подтверждающих прогностичес-кую значимость СОТ у больных с ОКС [32,41,42]. По крайней мере, в одном исследовании была выявлена корреляция СОТ с риском тромбо-зов после ЧКВ у больных со стабильной ИБС [43].…”

Section: средний объем тромбоцитов у больных с сердечно-сосудистыми пunclassified

Platelet Turnover and Atherothrombosis

Мазуров¹

2017

Aterotromboz

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ОБОРОТ ТРОМБОЦИТОВ И АТЕРОТРОМБОЗА.В. МАЗУРОВ, д.м.н., профессор, Научный медицинский исследовательский центр кардиологии Минздрава России, Москва КЛЮЧЕВЫЕ СЛОВА: тромбоциты, атеротромбоз, ретикулярные тромбоциты, средний объем тромбоцитов, агрегация тромбоцитов, мегакариоциты, тромбоцитопоэз Тромбоциты играют ведущую роль в инициации атеротромбоза -образования внутрисо-судистых тромбов в участках атеросклеротическом повреждении сосудов. Функциональ-ная (протромботическая) активность тромбоцитов существенным образом варьирует как у здоровых лиц, так и у пациентов с сердечно-сосудистыми заболеваниями. Одной из причин повышения активности тромбоцитов может быть ускорение их продукции и оборота. При стимуляции тромбоцитопоэза в кровотоке появляются крупные и ретику-лярные (с повышенным количеством РНК) «молодые» тромбоциты. Эти тромбоциты со-держат больше адгезивных рецепторов, больше секреторных гранул и обладают повы-шенной способностью к агрегации. В обзоре приводятся данные, указывающие на то, что крупные и ретикулярные тромбоциты являются не только маркерами, но и предик-торами атеротромботических событий, и в первую очередь острого коронарного синдро-ма. Увеличение количества таких тромбоцитов у больных, получающих антитромбоци-тарные препараты, ассоциировано со снижением эффективности их антиагрегантного действия. Предполагается, что появление крупных и ретикулярных тромбоцитов в кро-ви больных с атеросклерозом и атеротромбозом может быть следствием повышения тромбопоэтической активности мегакариоцитов при этих патологических состояниях.KEYWORDS: thrombocytes, atherothrombosis, reticular platelets, average platelet count, platelet aggregation, megakaryocytes, thrombocytopoiesis PLATELET TURNOVER AND ATHEROTHROMBOSIS A.V. MAZUROV, MD, Prof. National Medical Research Cardiology Center, Russian Ministry of Health, MoscowPlatelets play an important role in initiating atherothrombosis, i.e. the formation of blood clots inside a blood vessel at areas of atherosclerotic vascular injury. The functional (prothrombotic) activity of platelets significantly varies both in healthy individuals and in patients with cardiovascular diseases. The increased platelet production and turnover may be one of the reasons for promoting platelet activity. Stimulating thrombocytopoiesis results in large and reticular (with an increased amount of RNA) "young" platelets in the bloodstream. These platelets contain more adhesive receptors, more secretory granules and have an increased aggregation capacity. The review provides data indicating that large and reticular platelets are not only markers, but also predictors of atherothrombotic events, and primarily of acute coronary syndrome. An increase in such platelet count in patients receiving antiplatelet drugs is associated with a decrease in effectiveness of their antiplatelet action. It is assumed that the appearance of large and reticular platelets in the blood of patients with atherosclerosis and atherothrombosis may be a consequence of an increase in the thrombopoietic activity of meg...

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Prognostic implications of mean platelet volume on short- and long-term outcomes among patients with non-ST-segment elevation myocardial infarction treated with percutaneous coronary intervention: A single-center large observational study

Abstract: In patients with NSTEMI treated with PCI, a high MPV value was associated with a significantly increased incidence of long-term adverse events, particularly for all-cause mortality.

Cited by 40 publications

References 30 publications

Impact of Obstructive Sleep Apnea on Platelet Function Profiles in Patients With Acute Coronary Syndrome Taking Dual Antiplatelet Therapy

Impact of Obstructive Sleep Apnea on Platelet Function Profiles in Patients With Acute Coronary Syndrome Taking Dual Antiplatelet Therapy

Association of mean platelet volume with presence of non-viable myocardium in ischaemic cardiomyopathy

Platelet Turnover and Atherothrombosis

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