Prognostic implications of prealbumin level on admission in patients with acute heart failure referred to a cardiac intensive care unit

Heart failure (HF) is a progressive systemic disease and a major public health problem in developed countries [1]. Despite modern progress in medical management, HF remains a common cause of recurrent hospitalization or death, and a number of prognostic predictors of HF have been reported, including age, New York Heart Association (NYHA) functional class, HF admission, clinical history of hypertension or chronic obstructive pulmonary disease, etiology of cardiomyopathy, blood pressure, brain natriuretic peptide (BNP) level, and parameters of echocardiography or electrocardiogram [2,3]. On the other hand, HF is a systemic clinical syndrome with multiple impaired organs due to low perfusion and congestion

Section: Usefulness Of Fr As a Prognostic Predictor In Heart Failurementioning

confidence: 99%

Usefulness of the plasma branched-chain amino acid/aromatic amino acid ratio for predicting future cardiac events in patients with heart failure

Hiraiwa

Okumura

Kondo

et al. 2020

“…In such cases, it may be difficult to accurately assess frailty status based on questionnaire surveys, and therefore objective parameters are useful for assessing frailty status in a hospital setting. Furthermore, although the frailty scale uses serum albumin levels to indicate malnutrition, a recent study reported that a combination of prealbumin level [29] and Mini Nutritional Assessment (MNA) can detect early malnutrition in the elderly [30] and predict prognosis in patients with AHF [31]. Further studies are required to verify whether these nutritional indicators are useful for determining frailty.…”

Section: Discussionmentioning

confidence: 99%

Rising time from bed in acute phase after hospitalization predicts frailty at hospital discharge in patients with acute heart failure

Nozaki

Hamazaki

Kamiya

et al. 2020

Frailty in geriatric patients is defined as a syndrome of reduced physiological reserve and vulnerability to stressors broadly classified as acute or chronic illnesses [1]. Frail individuals have markedly elevated risk of adverse health events [2], and frailty is a high-priority issue in cardiovascular medicine [3,4]. Heart failure (HF) is a leading cause of hospitalization [5], and is associated with poor prognosis and quality of life, as well as increased medical costs [6]. Frailty has significant effects on overall health as well as the clinical prognosis of elderly patients with HF [7]. Moreover, frailty at hospital discharge was reported to be associated with increased mortality rate [8]. Therefore, earlier prediction of frailty at discharge is necessary in elderly patients with HF at the time of hospitalization to allow appropriate clinical management, therapeutic decision-making, and for risk stratification. In addition, to predict frailty at discharge, an assessment tool is required that can be used conveniently, rapidly, safely, and immediately after admission. Some previous studies reported that rising from bed, including required time, is associated with decreased activities of daily living (ADLs) [9]. Therefore, we hypothesized that the rising time from bed measured immediately after admission could predict frailty at discharge and/or reduced physical performance with prognostic significance.

“…In our cohort, sarcopenia was related to higher rate of prior heart failure and lower levels of hemoglobin and albumin. Malnutrition and cachexia, caused by chronic diseases, such as heart failure, are considered to be among the causes of sarcopenia [24,25]. On the other hand, sarcopenic obesity was related to higher rates of hypertension, dyslipidemia, diabetes mellitus, and chronic kidney disease.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, sarcopenic obesity has been reported to be related to reduce levels of vitamin D and elevated risk of hypertension [37,38]. Advanced age is closely associated with poor prognosis in cardiovascular disease, which may be related to reduced nutritional status, including low vitamin D levels [39], low prealbumin level [24], and low serum amino acid concentration [25]. The results of the present study are supported by these previous reports, and these findings may at least partially correspond to the underlying reasons for the association between sarcopenic obesity and poorer survival rate.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of sarcopenic obesity estimated by computed tomography in patients with cardiovascular disease and undergoing surgery

Kamiya

Matsunaga

Kitamura

et al. 2019

The incidence of sarcopenia is increasing as the world's population is aging [1,2], and the prevalence rates are especially high in patients with cardiovascular disease [3]. Sarcopenia is accompanied by loss of muscle mass, which is a powerful predictor of mortality in aging cardiovascular disease patients [3]. Diagnosis of sarcopenia in the elderly is important because of its close relation to adverse outcomes following cardiovascular surgery [4].Sarcopenia identified by computed tomography (CT) was reported to be a useful predictor of mortality in patients with cancer [5], cardiovascular disease [6], and transcatheter aortic valve implantation (TAVI) [7]. There have been a number of studies regarding the utility of skeletal muscle density as a prognostic