Prognostic implications of synaptophysin, CD56, thyroid transcription factor-1, and Ki-67 in pulmonary high-grade neuroendocrine carcinomas

He, Yulong; Zhao, Lei; Tang, Xiaorong; Jiang, Qinling; Zhao, Xianling; Cao, Yilin

doi:10.1016/j.anndiagpath.2023.152239

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…Thymic carcinoma is positive for CK5 and CD117 immunoreactivity ( 16 ). Established IHC markers for diagnosing neuroendocrine tumor neoplasms include Syn, CD56 and TTF-1, which demonstrate notable sensitivity and specificity in their diagnostic utility ( 17 – 19 ). IHC staining for GATA3 in mediastinal masses is not routinely performed by the Affiliated Hospital of Weifang Medical University (Weifang, China).…”

Section: Discussionmentioning

confidence: 99%

Occult urothelial carcinoma with mediastinal metastasis: A case report

Zheng,

Peng,

et al. 2024

Oncol Lett

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Occult urothelial carcinoma (UC), particularly with mediastinal metastases, is an uncommon clinical occurrence. The present study describes the unusual case of a 70-year-old male patient who developed mediastinal metastases from an occult UC. Histological evaluations and immunohistochemical features of the mediastinal tumor were indicative of UC; however, extensive imaging failed to identify the primary urological lesion. The findings suggest that mediastinal metastases from UCs, despite their rarity, should be considered in cases where patients with mediastinal tumors exhibit chest-related symptoms. Prompt pathological examinations are crucial for ascertaining the nature and origin of the tumor. Moreover, individualized treatment should be performed in strict accordance with the established oncology guidelines.

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Section: Discussionmentioning

confidence: 99%

Occult urothelial carcinoma with mediastinal metastasis: A case report

Zheng,

Peng,

et al. 2024

Oncol Lett

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SNAP25-induced MYC upregulation promotes high-grade neuroendocrine lung carcinoma progression

Chen,

Wang,

Wang

et al. 2024

Front. Immunol.

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BackgroundThis study investigated the expression and role of Synaptosome associated protein 25 (SNAP25) in high-grade neuroendocrine carcinoma (HGNEC).MethodsWe used differentially expressed analysis and weighted gene co-expression network analysis (WGCNA) to identify key genes and modules in HGNEC. KEGG and GO analyses helped understand these genes’ roles, and ROC curves assessed their diagnostic value. We also studied SNAP25’s relation to immune infiltration and confirmed findings with in vitro and vivo experiments and datasets.ResultsWGCNA identified 595 key genes related to pathways like MAPK signaling, GABAergic synapse, and cancer-related transcriptional misregulation. Top genes included SNAP25, MYC, NRXN1, GAD2, and SYT1. SNAP25 was notably associated with M2 macrophage infiltration. Dataset GSE40275 confirmed SNAP25’s high expression and poor prognosis in HGNEC. qRT-PCR and WB analyses showed increased SNAP25 and c-MYC levels in HGNEC, promoting MEK/ERK pathway activity. Reducing SNAP25 decreased H1299 cell proliferation, migration, invasion, and levels of c-MYC, MEK, and ERK. Finally, in vivo experiments further confirmed that SNAP25 knockout can inhibit tumor growth.ConclusionSNAP25 regulates c-MYC activation by stimulating the MEK/ERK pathway, ultimately influencing the development of HGNEC.

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Prognostic implications of synaptophysin, CD56, thyroid transcription factor-1, and Ki-67 in pulmonary high-grade neuroendocrine carcinomas

Cited by 2 publications

References 27 publications

Occult urothelial carcinoma with mediastinal metastasis: A case report

Occult urothelial carcinoma with mediastinal metastasis: A case report

SNAP25-induced MYC upregulation promotes high-grade neuroendocrine lung carcinoma progression

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