2021
DOI: 10.1016/j.humpath.2021.05.001
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Prognostic implications of the coexisting precursor lesion types in invasive gallbladder cancer

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Cited by 21 publications
(30 citation statements)
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“…In the present patient, the lesion was diagnosed as biliary morphologic ICPN with associated invasive carcinoma according to the predominant morphological pattern. Although ICPN is considered a precancerous lesion [ 9 ], the natural history of ICPN has not been well investigated. In this case, the accurate time when ICPN developed in the patient’s remnant gallbladder and when the lesion became invasive are uncertain.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In the present patient, the lesion was diagnosed as biliary morphologic ICPN with associated invasive carcinoma according to the predominant morphological pattern. Although ICPN is considered a precancerous lesion [ 9 ], the natural history of ICPN has not been well investigated. In this case, the accurate time when ICPN developed in the patient’s remnant gallbladder and when the lesion became invasive are uncertain.…”
Section: Discussionmentioning
confidence: 99%
“…The 5-year survival rate for patients with non-invasive ICPN is 78%, whereas patients with invasive carcinoma have a 5-year survival rate of 60% [ 2 ]. Even when only ICPN with associated invasive carcinoma is considered, the overall survival outcome of ICPN is incomparably better than that of the non-ICPN-associated ordinary-type gallbladder adenocarcinoma, which has a 5-year survival rate ranging from 18 to 30% [ 2 , 9 ]. In contrast, the fact that some patients with non-invasive ICPN die of biliary tract cancer, typically long after the diagnosis of ICPN, suggests that a field effect rendering the remainder of the biliary tract at risk of carcinoma [ 1 ].…”
Section: Discussionmentioning
confidence: 99%
“…Akita et al 12 defined ICPN exactly showing overall uniform papillary architecture throughout the tumor and other carcinomas containing papillary configurations were pooled in “papillary gallbladder carcinoma”. However, tubular components are not uncommon in ICPN cases proposed by the current WHO terminology, 1,2 so some cases of ICPN with tubular components fulfilling ICPN could be included in “papillary gallbladder carcinoma” proposed by Akita et al 12 Mochidome et al 16 classified invasive gallbladder carcinomas into those with ICPN, those with papillary neoplasia and those without these changes. However, the classification of ICPN and papillary neoplasia needs further studies.…”
Section: Discussionmentioning
confidence: 99%
“…could be included in "papillary gallbladder carcinoma" proposed by Akita et al 12 Mochidome et al 16 classified invasive gallbladder carcinomas into those with ICPN, those with papillary neoplasia and those without these changes. However, the classification of ICPN and papillary neoplasia needs further studies.…”
Section: Conflict Of Interestmentioning
confidence: 99%
“…Recently, Mochidome et al reported that invasive gallbladder adenocarcinoma cases with ICPN components had more favorable prognoses than those without, suggesting that invasive gallbladder carcinoma with exophytic papillary neoplasia may be biologically different from that without such lesions [ 32 ]. Two case reports have shown that ICPNs can grow inside Rolitansky–Ashoff sinuses [ 33 ] and protrude into the common bile duct [ 34 ].…”
Section: Intracholecystic Papillary Neoplasmmentioning
confidence: 99%