Prognostic Implications of Tissue Doppler Imaging–Derived E/Ea Ratio in Acute Heart Failure Patients

Santas, Enrique; García‐Blas, Sergio; Miñana, Gema; Sanchís, Juan; Bodı́, Vicent; Escribano, David; Muñóz, J. Cuesta; Chorro, Francisco J.; Núñez, Julio

doi:10.1111/echo.12617

Cited by 13 publications

(7 citation statements)

References 30 publications

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“…The ratio of transmitral peak E velocity to peak e′ velocity was calculated as an estimate of LV filling pressure by averaging e′ of 2 sites (septal and lateral: E/e′ ratio) . E/e′ ratio has been prognostically validated in patients with chronic and acute heart failure . All reported echo Doppler measurements were averaged from 3 cardiac cycles.…”

Section: Methodssupporting

confidence: 93%

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Left Ventricular Diastolic Dysfunction in Type I Gaucher Disease: An Echo Doppler Study

et al. 2014

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Type I Gaucher disease (GD1) is an autosomal recessive lysosomal storage disease characterized by multiorgan damage. Left ventricular (LV) involvement has been rarely reported. Accordingly, the aim of the study was to evaluate LV geometry and function in a series of patients with GD1. Eighteen patients with GD1, 18 age- and sex-matched normal controls, and 18 age- and sex-matched hypertensive patients (HTN) were compared by standard echo Doppler examination. LV mass index, relative wall thickness and ejection fraction, transmitral E/A ratio, E velocity deceleration time (DT), atrial filling fraction (AFF = time-velocity integral of A velocity/time-velocity integral of total diastole × 100), E/e' ratio, and left atrial volume index were determined. Nine GD1 patients also exhibited arterial hypertension. The intergroup difference of LV mass index and relative wall thickness was not significant. Transmitral E/A ratio was lower in HTN than in normal controls and GD1 (P < 0.05). GD1 exhibited longer DT than NC and HTN (P = 0.009). AFF was higher in GD1 and HTN compared to NC (P = 0.034). After adjustment for heart rate, GD1 was associated with longer DT (P < 0.001) and greater AFF (P = 0.036), while HTN was associated only with AFF (P = 0.013). No interaction was found between GD1 and HTN. In conclusion, GD1 is associated with subclinical LV diastolic dysfunction, which is independent of the coexistence of arterial hypertension. Subclinical LV impaired relaxation in the context of myocardial infiltrative damage could be the mechanism underlying these alterations.

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Section: Methodssupporting

confidence: 93%

“…18 E/e 0 ratio has been prognostically validated in patients with chronic and acute heart failure. 18,19 All reported echo Doppler measurements were averaged from 3 cardiac cycles.…”

Section: Methodsmentioning

confidence: 99%

Left Ventricular Diastolic Dysfunction in Type I Gaucher Disease: An Echo Doppler Study

et al. 2014

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“…In another study, 417 patients admitted with heart failure were followed for a median of 306 days [70]; an increase in E/ e' was linearly associated with increased all-cause mortality. E/e' ratio is also useful in detecting early LV DD in patients with untreated early onset hypertension and hyperinsulinaemia [71].…”

Section: E/ E' Ratiomentioning

confidence: 99%

Tissue Doppler Imaging in Echocardiography: Value and Limitations

Kadappu

Thomas

2015

Heart, Lung and Circulation

121

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“…Patients with SSc also have higher E/e’ ratios ( 53 ) (representing higher LV filling pressures) and increased isovolumetric relaxation times compared to controls ( 48 ). Interestingly, abnormal E/e’ ratio [defined as transmitral to mitral annular early diastolic velocity ratio ( 54 )] was also associated with duration of recognized SSc disease in months, as well as mean duration of Raynaud’s phenomenon, suggesting temporal relation in SSc-related fibrotic disease of different organs ( 49 ). Additionally, certain measurements may also predict mortality in SSc patients.…”

Section: Left Ventricular Dysfunctionmentioning

confidence: 99%

Cardiovascular Imaging for Systemic Sclerosis Monitoring and Management

Glynn

Hale

Hussain

et al. 2022

Front. Cardiovasc. Med.

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Systemic sclerosis (SSc) is a complex connective tissue disease with multiple clinical and subclinical cardiac manifestations. SSc can affect most structural components of the heart, including the pericardium, myocardium, valves, and conduction system through a damaging cycle of inflammation, ischemia, and fibrosis. While cardiac involvement is the second leading SSc-related cause of death, it is frequently clinically silent in early disease and often missed with routine screening. To facilitate identification of cardiac disease in this susceptible population, we present here a review of cardiac imaging modalities and potential uses in the SSc patient population. We describe well-characterized techniques including electrocardiography and 2D echocardiography with Doppler, but also discuss more advanced imaging approaches, such as speckle-tracking echocardiography, cardiovascular magnetic resonance imaging (CMR), and stress imaging, among others. We also suggest an algorithm for the appropriate application of these modalities in the workup and management of patients with SSc. Finally, we discuss future opportunities for cardiac imaging in SSc research to achieve early detection and to optimize treatment.

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Prognostic Implications of Tissue Doppler Imaging–Derived E/Ea Ratio in Acute Heart Failure Patients

Abstract: In AHF patients, tissue Doppler imaging derived E/Ea ratio is independently associated with an increased risk of all-cause mortality.

Cited by 13 publications

References 30 publications

Left Ventricular Diastolic Dysfunction in Type I Gaucher Disease: An Echo Doppler Study

Left Ventricular Diastolic Dysfunction in Type I Gaucher Disease: An Echo Doppler Study

Tissue Doppler Imaging in Echocardiography: Value and Limitations

Cardiovascular Imaging for Systemic Sclerosis Monitoring and Management

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