Prognostic implications of tissue oxygen saturation in human septic shock

Mesquida, Jaume; Espinal, C.; Gruartmoner, G.; Masip, Jordi; Sabatier, C.; Baigorri, F.; Pinsky, Michael R.; Artigas, Antonio

doi:10.1007/s00134-012-2491-6

Cited by 52 publications

(59 citation statements)

References 20 publications

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“…Similar findings have been reported in pediatric and adult critical care literature of continuous monitoring of dynamic changes in cardiovascular parameters in response to various factors [53]. Clinical applications of such functional hemodynamic monitoring include prediction of the patient's responsiveness to fluid administration [54e56], detection of compensated shock [57,58], and loss of arterial tone determination [59,60].…”

Section: Computational Modeling From Research To Patient Caresupporting

confidence: 56%

Hemodynamic monitoring of the critically ill neonate: An eye on the future

Azhibekov

Soleymani

Lee

et al. 2015

Seminars in Fetal and Neonatal Medicine

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Section: Computational Modeling From Research To Patient Caresupporting

confidence: 56%

Hemodynamic monitoring of the critically ill neonate: An eye on the future

Azhibekov

Soleymani

Lee

et al. 2015

Seminars in Fetal and Neonatal Medicine

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“…These novel parameters have been studied mostly in trauma and septic-shock patients, were they have consistently shown prognostic implications, independently from other cardiovascular parameters [26,27].…”

Section: Discussionmentioning

confidence: 99%

Thenar oxygen saturation during weaning from mechanical ventilation: an observational study

et al. 2013

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Our aim was to determine whether thenar tissue oxygen saturation (StO 2 ), measured by noninvasive near-infrared spectroscopy, and its changes derived from an ischaemic challenge are associated with weaning outcome.Our study comprised a prospective observational study in a 26-bed medical-surgical intensive care unit. Patients receiving mechanical ventilation for .48 h, and considered ready to wean by their physicians underwent a 30-min weaning trial. StO 2 was measured continuously on the thenar eminence. A transient vascular occlusion test was performed prior to and at the end of the 30-min weaning trial, in order to obtain StO 2 deoxygenation and reoxygenation rates, and estimated local oxygen consumption. 37 patients were studied. Patients were classified as weaning success (n524) or weaning failure (n513). No significant demographic, respiratory or haemodynamic differences were observed between the groups at inclusion. Patients who failed the overall weaning process showed a significant increase in deoxygenation and in local oxygen consumption from baseline to 30 min of weaning trial, whereas no significant changes were observed in the weaning success group.Failure to wean from mechanical ventilation was associated with higher relative increases in deoxygenation after 30 min of spontaneous ventilation. @ERSpublications Failure to wean from mechanical ventilation is associated with increases in deoxygenation after spontaneous ventilation

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“…CO 2 gaps more than 6 mmHg suggest inadequate blood flow for metabolic demand and can be used to guide resuscitation. Similarly, measuring the rate of tissue oxygen desaturation and recovery in response to a vascular occlusion test has been shown to identify underresuscitated trauma patients [86][87][88], predict survival from septic shock [89][90][91]. However, these and other measures of regional blood flow do not correlate well with macrocirculatory measures like changes in MAP and CO [92].…”

Section: Metabolic Measures Of Tissue Perfusionmentioning

confidence: 95%