Prognostic importance of IgE for the evolution of recurrent wheezing into the bronchial asthma in children

Sciuca, Svetlana

doi:10.1097/01.wox.0000301645.56025.54

Cited by 2 publications

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“…The rising level of serum IgE was originate to be statistically remarkable when assessed amid each of the groups (p <0.001) amongst intermittent and mild persistent cases and too amongst mild persistent and moderate persistent cases and p<0.05among moderate persistent and severe persistent cases. Similar observations made by Kovac et al, 24 and Sciuca et al, 25 Mean sputum eosinophil % found in severe asthmatic subjects was 2.6%, followed by 1.12% was in moderate and 0.42% in mild asthmatic subjects. Mean sputum eosinophil % increases considerably as per severity; demonstrate strong positive correlation.…”

Section: Resultssupporting

confidence: 88%

Association of induced sputum eosinophil, absolute eosinophil count and serum immunoglobulin E level in assessment of the clinical severity in bronchial asthma

Patel¹,

Patel²,

Gogdani³

2022

IJIRM

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The study was done with the aim to determine the relationship between the severity of asthma in patient and the level of serum immunoglobulin E, peripheral eosinophil count and nature of sputum.Current research was conducted at the Department of Respiratory Medicine, GAIMS, Bhuj, India over one year. All subjects of Bronchial asthma distinct by Genetic Information Nondiscrimination Act (GINA) guidelines of age 17-61 year were registered. Severity of asthma was assessed by clinical features and by Forced expiratory volume in the first second (FEV1 in spirometry. Following evaluating the sternness of bronchial asthma all subjects undergo sputum examination for sputum eosinophil counts, blood sampling for absolute eosinophil counts and serum IgE levels. Elevated sputum eosinophil count (>3) was significantly elevated in additional subjects with severe persistent asthma even though extra than half of them had normal sputum eosinophil. An important association amid peripheral eosinophil count, sputum eosinophil count, and serum IgE with severe persistent asthma. Mean sputum eosinophil% augments considerably according to severity, demonstrates though affirmative association which was statistically important.The use of inexpensive and easy method with evaluation of AEC, sputum eosinophil count and evaluation of serum IgE level showed a straight measurement of inflammation of airway and allergic etiology of illness.

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Section: Resultssupporting

confidence: 88%

Association of induced sputum eosinophil, absolute eosinophil count and serum immunoglobulin E level in assessment of the clinical severity in bronchial asthma

Patel¹,

Patel²,

Gogdani³

2022

IJIRM

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show abstract

“…25 A study done by Sciuca et al, in children with recurrent wheeze, showed that raised levels of tIgE was directly proportional to the increased risk of bronchial asthma in them. 26 Studies have shown that tIgE levels are associated with the severity of symptoms, risk of exacerbations and remodelling of the airways. 6 There is an association between the prevalence of asthma and the total serum tIgE levels, independent of specific reactivity to common allergens or symptoms of allergy.…”

Section: Discussionmentioning

confidence: 99%

Serum immunoglobulin E and absolute eosinophil count as markers of severity in childhood asthma

Trivedi¹,

Patel²

2020

Int J Contemp Pediatr

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Background: Asthma is a chronic inflammatory condition of the airways resulting in increased airway reactivity to a variety of stimuli like allergens, irritants, viruses and exercise. There is a strong association between the exposure of allergens and development of asthmatic symptoms. A hypersensitivity reaction initiated by immunologic mechanisms mediated by Immunoglobulin E (IgE) antibodies occurs in allergic asthma. IgE and eosinophils play an important role in the inflammatory process resulting in bronchial hyperresponsiveness. The aim of this study was to evaluate serum total IgE levels and Absolute Eosinophil Count (AEC) as markers of disease activity and study their association with the severity of bronchial asthma in children.Methods: A prospective study was conducted in the paediatric department of a tertiary care hospital in Ahmedabad, Gujarat, India from July 2017 to December 2018. Children between 4-14 years of age diagnosed as having bronchial asthma were included in the study. Serum total IgE levels and absolute eosinophil count were done in all the study participants and their correlation with the severity of asthma was assessed.Results: Of the total 109 patients of asthma, 44(40.4%) had intermittent asthma, 30(27.5%) mild persistent, 25(22.9%) moderate persistent and 10(9.2%) severe persistent asthma. Serum total IgE levels were raised above the normal limits for age in 94(86.2%) patients and increased AEC was found in 61(56 %) patients. Both serum total IgE levels and AEC increased significantly (p<0.0001) with increasing severity of asthma.Conclusions: Serum total IgE levels and AEC can be used to predict the severity of asthma in children.

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Prognostic importance of IgE for the evolution of recurrent wheezing into the bronchial asthma in children

Cited by 2 publications

References 0 publications

Association of induced sputum eosinophil, absolute eosinophil count and serum immunoglobulin E level in assessment of the clinical severity in bronchial asthma

Association of induced sputum eosinophil, absolute eosinophil count and serum immunoglobulin E level in assessment of the clinical severity in bronchial asthma

Serum immunoglobulin E and absolute eosinophil count as markers of severity in childhood asthma

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