Prognostic Importance of Tumor Deposits in the Ipsilateral Axillary Region of Breast Cancer Patients

Durak, Merih Güray; Canda, Tülay; Yilmaz, Betul; Şeker, Nazlı Sena; Kokkoz, Seda Eryiğit; Alıcıkuş, Zümre Arıcan; Aktürk, Nesrin; Görken, İlknur Bilkay; Ellıdokuz, Hülya; Sevinç, Ali İbrahim; Saydam, Serdar; Sarıoğlu, Sülen

doi:10.1007/s12253-018-0515-4

Cited by 2 publications

(5 citation statements)

References 22 publications

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“…[14,24] This definition seems to restrict the evaluation of TDs that is already challenging, however, the prognostic significance of TDs in the literature have been demonstrated in various organ cancers. [4–6,9,10,22,25] This case series of thyroid carcinomas support the aggressive behavior pattern of TDs in these tumors, as well.…”

Section: Discussionsupporting

confidence: 71%

“…The incidence of TDs varies between 16.6% and 43.9% in colorectal carcinomas, [10,11] 17.8% and 24.0% in gastric carcinomas, [4,22] 17.1% in head and neck carcinomas, [6] 28.0% in salivary gland tumors, [8] 24.6% in esophageal carcinomas, [23] and 29.0% in breast carcinomas. [9] In our case series, 44 patients with TPC (25.0%) and 10 patients with TMC (55.6%) had TDs. Although TPC and TMC are completely different neoplasms of the thyroid, in terms of both cells of origin, and clinical presentation and biological behavior, presence of TDs are investigated and presented in this study regardless of variances in distinct tumor types of the thyroid.…”

Section: Discussionmentioning

confidence: 71%

“…In our previous study, we had shown that the probability of distant metastasis was 3.3 times higher in breast cancer patients with TDs. [9] Jiang et al [33] has also reported that TDs are significant in predicting distant metastasis after rectal cancer surgery. Yabata et al [34] suggests that the prognostic impact of TDs on OS is between that of lymph node metastasis and distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…Any tumor mass in the adipose tissue devoid of lymph node architecture, either with regular or irregular contours, was identified as a TD [9,21] (Figs. 1 and 2).…”

Section: Methodsmentioning

confidence: 99%

“…[1] Although first reported in 1935, the interest in TDs arose particularly in the last 3 decades, with increasing literature about its association with poor prognosis in different cancer groups. [2][3][4][5][6][7][8][9] Most studies regarding the prognostic significance of TDs are in colorectal carcinomas, [2,[10][11][12][13] accordingly, in the recent American Joint Committee on Cancer classification system their presence change the nodal status to pN1c, if no metastatic regional lymph nodes are detected on pathological examination. [14] Thyroid carcinomas, particularly differentiated thyroid carcinomas arising from the follicular epithelial cells, are the most common endocrine malignancies.…”

Section: Introductionmentioning

confidence: 99%

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Tumor deposits in thyroid carcinomas

Guray Durak,

Gokcay,

Emecen

et al. 2024

Medicine

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Tumor deposits (TDs) are defined as discontinuous neoplastic masses within the lymphatic drainage pathway of the primary tumor. The poor prognostic implication of these masses have been demonstrated in various cancers. The aim of this study is to investigate the incidence of TDs in our thyroid carcinoma cases, which has not been studied so far to the best of our knowledge, and to determine the prognostic value of their existence. In this retrospective cohort study, 194 thyroid carcinoma cases with cervical lymph node sampling and/or dissection were reevaluated for TDs. The case series consisted of 176 thyroid papillary carcinoma (TPC) and 18 thyroid medullary carcinoma (TMC) patients. TDs were detected in 54 (27.8%) patients. TMC cases (55.6%) had significantly more TDs compared to TPCs (25.0%; P = .006). TDs were more common in women (P = .045), and in multifocal tumors (P = .017). In addition, cases with TDs had larger tumor size (P = .002), more lymphatic invasion (P = .009), extrathyroidal extension (P < .001), and distant metastasis (P < .001). The mean follow-up period of the patients was 120.1 months (range, 4–341 months). Locoregional recurrence detected in 17 patients (8.8%) was more common in TMC (33.3%) than TPC cases (6.3%; P = .002). Distant metastasis was identified in 27 patients (13.9%). Ten-year recurrence free survival (RFS) and overall survival (OS) for all patients were 89.0% and 92.4%, respectively. Mean estimated OS time for TD negative and TD positive cases were: 281.9 (±17.2), 325.6 (±6.2) and 217.6 (±27.4) months, respectively (P = .002). Sex (P = .001), tumor type (P = .002), pT classification of the tumor (P < .001), perineural invasion (P = .002) and TDs (P = .002) were significantly associated with OS. In TPC cases individually, extrathyroidal extension (P = .001) and TDs (P = .002) were significantly correlated with distant metastasis. In multivariate analysis, only tumor size was detected as an independent prognostic marker in TPC cases (P = .005). Our results demonstrate the existence of TDs in thyroid carcinoma cases, and indicate a more aggressive behavior pattern of TDs in these tumors.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

“…Any tumor mass in the adipose tissue devoid of lymph node architecture, either with regular or irregular contours, was identified as a TD [9,21] (Figs. 1 and 2).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tumor deposits in thyroid carcinomas

Guray Durak,

Gokcay,

Emecen

et al. 2024

Medicine

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Tumor deposits in axillary adipose tissue in patients with breast cancer: Do they matter?

Mubarak,

Rashid,

Shakeel

2024

World J Clin Cases

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Tumor deposits (TDs) are defined as discrete, irregular clusters of tumor cells lying in the soft tissue adjacent to but separate from the primary tumor, and are usually found in the lymphatic drainage area of the primary tumor. By definition, no residual lymph node structure should be identified in these tumor masses. At present, TDs are mainly reported in colorectal cancer, with a few reports in gastric cancer. There are very few reports on breast cancer (BC). For TDs, current dominant theories suggest that these are the result of lymph node metastasis of the tumor with complete destruction of the lymph nodes by the tumor tissue. Even some pathologists classify a TD as two lymph node metastases for calculation. Some pathologists also believe that TDs belong to the category of disseminated metastasis. Therefore, regardless of the origin, TDs are an indicator of poor prognosis. Moreover, for BC, sentinel lymph node biopsy is generally used at present. Whether radical axillary lymph node dissection should be adopted for BC with TDs in axillary lymph nodes is still inconclusive. The present commentary of this clinical issue has certain guiding significance. It is aimed to increase the awareness of the scientific community towards this under-recognized problem in BC pathology.

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Prognostic Importance of Tumor Deposits in the Ipsilateral Axillary Region of Breast Cancer Patients

Cited by 2 publications

References 22 publications

Tumor deposits in thyroid carcinomas

Tumor deposits in thyroid carcinomas

Tumor deposits in axillary adipose tissue in patients with breast cancer: Do they matter?

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