Prognostic Indicators in Differentiated Thyroid Carcinoma

Dean, Diana S.; Hay, Ian D.

doi:10.1177/107327480000700302

Cited by 147 publications

(96 citation statements)

References 39 publications

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“…In addition to the TNM staging system, prognostic scoring systems based on patient age, tumor grade, ex- tent and size (AGES) [1,2] or based on patient age, tumor metastases, extent and size (AMES) [2][3][4] have been advocated for determining the prognosis of welldifferentiated thyroid cancer. Taking these prognostic factors into account, a questionnaire survey was conducted, covering therapeutic options for well-differentiated thyroid cancer according to tumor size and the degree of prognostic risk.…”

Section: Discussionmentioning

confidence: 99%

“…Taking these prognostic factors into account, a questionnaire survey was conducted, covering therapeutic options for well-differentiated thyroid cancer according to tumor size and the degree of prognostic risk. In this study, the degree of prognostic risk was based on the commonly used, worldwide, AMES system [2][3][4]. The results of the questionnaire survey conducted in Japan have already been reported elsewhere [5,6].…”

Section: Discussionmentioning

confidence: 99%

“…This marked discrepancy between Japan and foreign countries may be explained by the treatment concept that high-dose 131 I radiotherapy following total thyroidectomy can ultimately be administered. The presence or absence of lymph node involvement is not included in the commonly recognized worldwide systems for the degree of prognostic risk, such as AGES [1,2] and AMES [2][3][4]. However, paratracheal lymph nodes, at least on the affected side, should be completely dissected in patients undergoing thyroidectomy, considering the risks of developing recurrent nerve paralysis due to postoperative regional lymph node recurrence and transformation into undifferentiated malignancy.…”

Section: Treatment Modalities For Minimally Invasive Papillary Carcinmentioning

confidence: 99%

“…There is considerable controversy regarding the extent of lymph node dissection. However, it was reported in Japan that lymph node dissection may be associated with a decrease in local recurrence [2][3][4] and as such lymph node dissection is favored. However, the presence or absence of lymph node involvement is not covered by the representative prognostic scoring system adopted in Western countries.…”

Section: Treatment Modalities For Large Papillary Thyroid Carcinomas mentioning

confidence: 99%

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Unique Treatment Policy for Well-differentiated Thyroid Cancer in Japan: Results of a Questionnaire Distributed to Members of the Japanese Society of Thyroid Surgery and the International Association of Endocrine Surgeons

2006

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Abstract. Although surgery has been the mainstay of treatment for patients with well-differentiated thyroid cancer, the extents of thyroid resection and lymph node dissection adopted in Japan differ from those in other countries. Furthermore, regarding the indications for postoperative radiation therapy and hormonal therapy, and treatment modalities for cancer recurrence, there are marked discrepancies between Japan and other countries. A questionnaire survey was thus conducted among domestic and overseas thyroid surgeons to ascertain the actual treatment policy for well-differentiated thyroid cancer in Japan and various foreign countries. For small papillary carcinomas of 2.0 cm or less (T1), thyroid resection was more extensive in foreign countries than in Japan, although the extent of lymph node dissection was limited in the former. For large papillary carcinomas exceeding 3.0 cm (T2), on the other hand, total thyroidectomy was the treatment of first choice for all overseas respondents, but of only 20% in Japan, despite lymph node dissection being more extensive in Japan than in other countries. Overseas surgeons were much more likely to favor postoperative TSH suppression therapy and high-dose 131 I therapy. For recurrence following surgery for papillary thyroid cancer, both domestic and overseas respondents indicated surgical resection to be the most common treatment option, and favored high-dose 131 I therapy as well. In Japan, however, high-dose 131 I therapy is available only in a few institutions. Such limited indications for highdose 131 I therapy in Japan may reflect a discrepancy in the frequency of total thyroidectomy, a prerequisite for postoperative high-dose 131 I therapy, between Japan and other countries. This is the first questionnaire study conducted in both Japan and other countries in relation to treatment modalities for thyroid cancer. The results reveal that there is a clear disparity in treatment policies between Japan and foreign countries.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Treatment Modalities For Minimally Invasive Papillary Carcinmentioning

confidence: 99%

Section: Treatment Modalities For Large Papillary Thyroid Carcinomas mentioning

confidence: 99%

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Unique Treatment Policy for Well-differentiated Thyroid Cancer in Japan: Results of a Questionnaire Distributed to Members of the Japanese Society of Thyroid Surgery and the International Association of Endocrine Surgeons

2006

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“…[7][8][9][10] Many prognostic scoring systems ( [EORTC]) have been used to estimate diseasefree survival and cause-specific mortality in patients with thyroid cancer. [11][12][13][14] The main use of these risk classification systems is to identify patients with a poor prognosis, to ensure that they receive additional treatment such as radioiodine ablation, and to achieve closer follow-up monitoring. 15 Unfortunately, none of these staging systems include data that are completely available preoperatively to guide the extent of initial surgical resection necessary.…”

mentioning

confidence: 99%

Diagnostic and extent of disease multigene assay for malignant thyroid neoplasms

Kebebew

Peng

Reiff

et al. 2006

Cancer

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Objective Intracranial arterial dolichoectasia (IADE), also called dilatative arteriopathy of the brain, is defined as an increase in length and diameter of intracranial arteries. Abdominal aortic aneurysm and ectasia of coronary arteries have been reported in association with IADE. In both conditions, a dysfunction of matrix metalloproteinases (MMP)‐2, ‐3, and ‐9 have been found. Our aim was to investigate these MMP pathways in stroke patients with IADE. Methods Five hundred ten Caucasians patients with brain infarction were consecutively recruited at 12 centers. The diagnosis of IADE was made by consensus between 2 neurologists based on magnetic resonance imaging scans. Determination of MMP‐2, ‐3, and ‐9 plasma levels was centralized in 1 laboratory. Because we found a threshold effect of MMP‐3 plasma levels with the risk of IADE, determination of the MMP‐3 5A/6A polymorphism was carried out. Results IADE was identified in 12% of stroke patients. There was no association of IADE with mean MMP‐2, ‐3, and ‐9 plasma levels. After categorization of MMP plasma levels into tertiles, we found a higher risk of IADE with the lowest MMP‐3 tertile (adjusted odds ratio [OR], 2.48; 95% confidence interval [CI], 1.17–5.23). In genotype analysis, there was a significant additive effect of the 5A allele on the risk of IADE, with an adjusted OR of 1.62 (95% CI, 1.03–2.55). Interpretation In this cohort of stroke patients of Caucasian ancestry, IADE was associated with low MMP‐3 plasma levels and with the 5A/6A polymorphism of the promoter region of MMP‐3. These results suggest that MMP‐3 may play a role in IADE. ANN NEUROL 2010;67:508–515

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Bronchoscopic Diagnosis of Thyroid Cancer With Laryngotracheal Invasion

Koike

Yamashita²,

Noguchi³

et al. 2001

Arch Surg

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Hypothesis: Some controversy exists concerning the appropriate surgical management for patients with thyroid cancer invading the laryngotracheal wall. We have used shaving of the wall when cancer invasion was confined to the perichondrium, and extensive resection when it invaded further. Preoperative assessment of the depth and length of laryngotracheal invasion is important when choosing an appropriate surgical procedure.

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Prognostic Indicators in Differentiated Thyroid Carcinoma

Abstract: A better understanding of independently important prognostic variables will result in improved patient care and treatment.

Cited by 147 publications

References 39 publications

Unique Treatment Policy for Well-differentiated Thyroid Cancer in Japan: Results of a Questionnaire Distributed to Members of the Japanese Society of Thyroid Surgery and the International Association of Endocrine Surgeons

Unique Treatment Policy for Well-differentiated Thyroid Cancer in Japan: Results of a Questionnaire Distributed to Members of the Japanese Society of Thyroid Surgery and the International Association of Endocrine Surgeons

Diagnostic and extent of disease multigene assay for malignant thyroid neoplasms

Bronchoscopic Diagnosis of Thyroid Cancer With Laryngotracheal Invasion

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