Prognostic markers and long-term outcome of placental-site trophoblastic tumours: a retrospective observational study

A rare cause for gestational trophoblastic neoplasia: Placental site trophoblastic tumor

“…Although most patients with placental-site trophoblastic tumours can be cured, a substantial number of patients have recurrent disease. For such patients, Schmid et al reported that the outcome is poor with only 33% achieving long-term remission [6]. In this series, patients with stage I disease had a 10-year probability of overall survival of 90% and did not benefit from postoperative chemotherapy.…”

“…Thus, B-hCG appears to have no predictive value and disease may still progress even if levels are not raised. The range of serum B-hCG concentration at diagnosis in 69% is below 1000 IU/L [6]. The explanation of this moderated elevation of B-hCG is that these cells produce primarily more hPL and less B-hCG.…”

“…The majority of the 200 cases published in the English literature so far have had good prognosis but rapidly metastasizing, and fatal cases have also been reported. In a review of 62 PSTT women treated at three gestational trophoblastic disease centres in United Kingdom, 23% patients died resulting in a probability of overall survival of 73% at 5 years and 70% at 10 years [6]. Previous reports have demonstrated that age older than 35 years, deep myometrial invasion (>1/2), high mitotic rate (>5 per 10 HPF), clear cytoplasm, coagulative necrosis, vascular space involvement, prior term pregnancy, and increased interval from previous pregnancy are important factors in the prognosis of these tumors [7].…”

“…Previous reports have demonstrated that age older than 35 years, deep myometrial invasion (>1/2), high mitotic rate (>5 per 10 HPF), clear cytoplasm, coagulative necrosis, vascular space involvement, prior term pregnancy, and increased interval from previous pregnancy are important factors in the prognosis of these tumors [7]. However, Schmid et al reported that only time (>48 months) since antecedent pregnancy remained significantly associated with multivariate analyses after adjustment for the FIGO score [6].…”

A Rare Gestational Trophoblastic Disease: Placental Site Trophoblastic Tumor

“…Typically, it occurs in women of reproductive age and may occur after any pregnancy (4). Although a majority of GTNs are extremely sensitive to chemotherapy, PSTT is relatively resistant to it (5). The purpose of this study was to present a 31-year-old case that presented to our clinic with complaints of irregular vaginal bleeding and was diagnosed with PSTT as a result of tests and examinations that were performed.…”