Prognostic MicroRNAs in Cancer Tissue from Patients Operated for Pancreatic Cancer—Five MicroRNAs in a Prognostic Index

Schultz, Nicolai Aagaard; Andersen, Klaus Kaae; Roslind, Anne; Willenbrock, Hanni; Wøjdemann, Morten; Johansen, Julia S.

doi:10.1007/s00268-012-1705-y

Cited by 80 publications

(79 citation statements)

References 65 publications

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“…Of note, two of the included miR-21 studies, by Kadera et al [46] and Shultz et al [41], did not find a significant association between miR-21 tumoural expression and OS using univariate analyses (Additional file 3: Fig. S1A).…”

Section: Oncomir-21mentioning

confidence: 94%

“…Of these, 11 studies (85%, 11/13) [18,34,35,[39][40][41][42][43][44]46] used tissue (n = 889) and two studies (15%, 2/13) [43,47] used blood samples from PDAC patients (n = 215). Four studies (n = 376), reported the effect of miR-21 up-regulation on OS using analyses unadjusted for other factors [35,41,43,46]. As shown in Additional file 3: Fig.…”

Section: Oncomir-21mentioning

confidence: 99%

“…The full texts of 18 papers (published 2007-2014) fulfilling the criteria for meta-analysis were obtained, describing 20 studies from 15 research groups [12,18,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47]. The study by Hwang et al [34] contained two independent cohorts (analysed separately), and the report by Wang et al [43] contained a tissue cohort and a blood sample cohort.…”

Section: Included Studiesmentioning

confidence: 99%

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microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis

Frampton¹,

Krell²,

Jamieson³

et al. 2015

European Journal of Cancer

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Section: Oncomir-21mentioning

confidence: 94%

Section: Oncomir-21mentioning

confidence: 99%

Section: Included Studiesmentioning

confidence: 99%

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microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis

Frampton¹,

Krell²,

Jamieson³

et al. 2015

European Journal of Cancer

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“…Up to now, over 700 miRNAs have been identified (Li et al, 2009). Many miRNAs such as let-7, miR15a, miR 21, miR 34a and miR 155 have been found to be associated with different kinds of cancer including lung, pancreas and colon cancers (Li et al, 2011;Okayama et al, 2012;Schultz et al, 2012;Rothschild, 2013). Any changes in the expression level of specific miRNAs are believed to be involved in cancer progression and can be prognostically indicative for human cancers (Bullock et al, 2013;Kahlert et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effect of miR27a on Proliferation and Invasion in Colonic Cancer Cells

Gao¹,

Li²,

Liu³

2013

Asian Pacific Journal of Cancer Prevention

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The aim of this study was to detect the expression of miR196a, miR146a, miR27a and miR200a in patients with colon cancer, and investigate the effect of miR27a expression on proliferation and invasion in colonic cancer cells. RT-PCR was employed to detect the expression levels in colon cancers. Then, colon cancer cells were cultured and transfected with 100 nM of miR27a mimics (80 nmol/L) or 80 nM miR27a inhibitors (80 nmol/L) in 24-well plates. Proliferation and invasion of colonic cancer cells were then determined by CCK-8 and Transwell assays, respectively. Our data showed miR27a to be high-expressed in patients with colon cancer. In addition, proliferation and invasion in the miR27a mimic group were significantly higher than in the control group and negative group (P<0.05), while, proliferation and invasion in the miR27a inhibitor group were obviously lowered (P<0.05). In conclusion, high expression of miR27a may play an important role in enhancing proliferation and invasion of colon cancer cells. Keywords: Colon cancer cells -miR27a -proliferation -invasion RESEARCH ARTICLE Effect of miR27a on Proliferation and Invasion in Colonic Cancer CellsYang Gao*, Bao-Dong Li, Yong-Gang Liu investigate the role of miR27a expression on colon cancer cells proliferation and invasion.

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“…Therefore, miR-203 is involved in tumor cell differentiation, proliferation and metastasis, and is thought to be a tumor suppressor. However, upregulation of miR-203 has been found in multiple tumor types including colorectal cancer [26, 32, 36], pancreatic cancer [34, 35, 37], renal cell carcinoma [28], breast cancer [25, 33] and ovarian cancer [31], indicating that miR-203 may also exhibit oncogenic potential, likely due to its ability to induce MET and promote metastatic colonization at distant sites [26]. Thus, it is controversial that whether miR-203 expression can be used as a prognostic biomarker in cancer.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Prognostic Value of microRNA-203 in Solid Tumors Based on a Meta-Analysis and the Cancer Genome Atlas (TCGA) Datasets

Shao

Ning

et al. 2017

Cell Physiol Biochem

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Background: It has been reported that miR-203 expression was aberrant in various types of cancers, and it could be used as a prognostic biomarker. Therefore, in this study, we aimed to evaluate the prognostic value of miR-203 expression in solid tumors by using meta-analysis and The Cancer Genome Atlas (TCGA) datasets. Methods: By doing a literature research in PubMed, Embase and the Cochrane Library (last update by December 2016), we were able to identify the studies assessing the prognostic role of miR-203 in various tumors. We then used TCGA datasets to validate the results of meta-analysis. Results:33 studies from 26 articles were qualified and enrolled in this meta-analysis. Pooled analyses showed that higher expression of miR-203 in tissues couldn’t predict poor overall survival (OS) and progression-free survival (PFS) in solid tumors. However, the results of subgroup analyses revealed that the upregulation of tissue miR-203 expression was associated with poor OS in colorectal cancer (hazard ratio (HR)=1.81, 95% confidence intervals (CI) 1.31-2.49; P<0.001), pancreatic cancer (HR=1.19, 95% CI 1.09-1.31; P<0.001) and ovarian cancer (HR=1.85, 95% CI 1.45-2.37; P<0.001); but it had opposite association in liver cancer (HR=0.52, 95% CI 0.28-0.97; P=0.040) and esophageal cancer (HR=0.41, 95% CI 0.25-0.66; P<0.001). Based on TCGA datasets, we found the same results for pancreatic cancer and esophageal cancer, but not for colorectal cancer and liver cancer. Moreover, patients with high circulating miR-203 in blood had significantly poor OS and PFS in colorectal cancer and breast cancer. Conclusion: Our study showed that the prognostic values of tissue miR-203 varied in different tumor types. In addition, the upregulation of circulating miR-203 in blood was associated with poor prognosis in colorectal cancer and breast cancer.

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Prognostic MicroRNAs in Cancer Tissue from Patients Operated for Pancreatic Cancer—Five MicroRNAs in a Prognostic Index

Abstract: The combination of five miRNAs expression in non micro-dissected FFPE PC tissue can identify patients with short OS after radical surgery. The results are independent of chemotherapy treatment. Patients with a prognostic index > median had a very short median OS of only 1 year.

Cited by 80 publications

References 65 publications

microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis

microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis

Effect of miR27a on Proliferation and Invasion in Colonic Cancer Cells

Evaluating the Prognostic Value of microRNA-203 in Solid Tumors Based on a Meta-Analysis and the Cancer Genome Atlas (TCGA) Datasets

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