Prognostic nomogram for the combination therapy of percutaneous catheter drainage and antibiotics in pyogenic liver abscess patients

Xu, Sheng; Shi, Baoqi; Chao, Lu-meng; Tan, Yulin; Zhang, Xue-Jun

doi:10.1007/s00261-019-02359-8

Cited by 12 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As described previously [23], the establishment of the nomogram was based on the results of multivariable Cox regression analyses of the training cohort. The nomogram was constructed with the regression modeling strategies package in R package.…”

Section: Discussionmentioning

confidence: 99%

Survival prediction for non-small cell lung cancer patients treated with CT-guided microwave ablation: development of a prognostic nomogram

et al. 2021

International Journal of Hyperthermia

Self Cite

View full text Add to dashboard Cite

Objectives: To explore the outcomes of CT-guided percutaneous microwave ablation (MWA) in nonsmall cell lung cancer (NSCLC) patients, and then develop an effective nomogram to predict the survival. Methods: NSCLC patients treated with MWA were randomly allocated to either the training cohort or the validation cohort (3:1). The primary outcome measurement was overall survival (OS), whose predictors were identified by univariate and multivariate analyses in the training cohort. Then, a predictive nomogram was developed to predict the OS, with the predictive accuracy evaluated by C-statistic and receiver operating characteristic in both the training and validation cohorts. Results: A total of 234 patients (training cohort: n ¼ 176; validation cohort: n ¼ 58) and 271 tumors with a median OS of 17.0 ± 12.2 months were included. The predictors selected into the nomogram included tumor diameter (hazard ratio [HR], 2.12; 95% confidence interval [CI], 1.37-3.30; p < 0.001), extrapulmonary metastases (HR, 1.77; 95% CI, 1.06-2.95; p ¼ 0.030), tumor stage (HR, 1.38; 95% CI, 1.07-1.79; p ¼ 0.013), tumor type (HR, 2.00; 95% CI, 1.48-2.72; p < 0.001) and post-MWA TKIs (HR, 0.55; 95% CI, 0.34-0.89; p < 0.001), based on the results of univariate and multivariate analyses. The C-statistic showed good predictive performance, with a C-statistic of 0.838 (95% CI, 0.779-0.897) internally and 0.808 (95% CI, 0.695-0.920) externally (training cohort and validation cohort, respectively). Conclusions: The nomogram was effective in predicting the OS in NSCLC patients treated with MWA, and could be applied to identify patients who may benefit most from MWA and be helpful for clinical decision making.

show abstract

Section: Discussionmentioning

confidence: 99%

Survival prediction for non-small cell lung cancer patients treated with CT-guided microwave ablation: development of a prognostic nomogram

et al. 2021

International Journal of Hyperthermia

Self Cite

View full text Add to dashboard Cite

show abstract

“…Pyogenic liver abscess (PLA) is a serious yet relatively uncommon infectious disease with severe morbidity and mortality [1]. Its clinical incidence varies depending on the populations being studied, but the incidence has been reported to range from 1.07 to 3.59 per 100,000 hospital admissions in the West and up to 17.59 per 100,000 in the East [2]. Moreover, the mortality rate has a range of 2.8-10.8% [3].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of platelet count-related ratios on admission in patients with pyogenic liver abscess

Yu¹,

Qin²,

Peng³

et al. 2022

BMC Infect Dis

View full text Add to dashboard Cite

Objective The purpose of the current study was to evaluate the association between C-reactive protein-to-platelet ratio (CPR), neutrophil-to-lymphocyte*platelet ratio (NLPR) and fibrinogen-to-platelet ratio (FPR) and the prognoses of pyogenic liver abscess (PLA) patients. Methods A cohort of 372 patients with confirmed PLA were enrolled in this retrospective study between 2015 and 2021. Laboratory data were collected on admission within 24 h. The demographic characteristics and clinical features were recorded. Risk factors for outcomes of PLA patients were determined via multivariate logistic regression analyses, and optimal cut-off values were estimated by using the receiver operating characteristic (ROC) curve analysis. Results Out of 372 patients, 57.8% were men, 80 (21.5%) developed sepsis, and 33 (8.9%) developed septic shock. The levels of CPR, NLPR and FPR were significantly increased in the development of sepsis, and prolonged hospital stays in PLA patients. The multivariate logistic regression analysis indicated that the CPR (OR: 2.262, 95% CI: 1.586–3.226, p < 0.001), NLPR (OR: 1.118, 95% CI: 1.070–1.167, p < 0.001) and FPR (OR: 1.197, 95% CI: 1.079–1.329, p = 0.001) were independent risks of PLA patients with sepsis, and NLPR (OR: 1.019, 95% CI: 1.004–1.046, p = 0.019) was shown to be an independent predictor of prolonged hospital stays. The ROC curve results showed that the three biomarkers had different predictive values, and CPR proved to work best, with a ROC value of 0.851 (95% CI: 0.807–0.896, p < 0.001) for sepsis. Conclusion Higher levels of CPR, NLPR and FPR were associated with a higher risk of poor outcomes. Moreover, a high CPR level performed best when predicting the clinical outcome in PLA patients.

show abstract

“…A global tendency for their frequency to increase has been observed for years. PLA has an incidence rate of 1.07 to 3.59/100,000 in the West and up to 17.59/100,000 in the East [ 5 ]. Liver abscesses can be solitary or multiple.…”

Section: Pyogenic Liver Abscessmentioning

confidence: 99%

Liver abscesses – from diagnosis to treatment

Kozielewicz¹,

Sikorska²,

Stalke³

2021

ceh

View full text Add to dashboard Cite

A liver abscess is a limited, often encysted, purulent inflammation with parenchymal necrosis that is a life-threatening complication of bacterial, fungal, protozoal and worm infections. Liver abscesses can be single or multi-ple; most of them are located in the right liver lobe. The pathogenic factor responsible for the development of abscesses can be identified by collecting the lesion’s contents or the cultures of blood, bile, sometimes urine or stool samples. Diagnosis is established by serological, imaging and microscopic tests. The treatment regimen is determined mainly by the etiological factor and the size of the lesion and includes conservative treatment and mainly percutaneous procedures. The article briefly presents the epidemiology, clinical picture and the current approach to the diagnosis and treatment of liver abscesses.

show abstract

Prognostic nomogram for the combination therapy of percutaneous catheter drainage and antibiotics in pyogenic liver abscess patients

Cited by 12 publications

References 36 publications

Survival prediction for non-small cell lung cancer patients treated with CT-guided microwave ablation: development of a prognostic nomogram

Survival prediction for non-small cell lung cancer patients treated with CT-guided microwave ablation: development of a prognostic nomogram

Prognostic value of platelet count-related ratios on admission in patients with pyogenic liver abscess

Liver abscesses – from diagnosis to treatment

Contact Info

Product

Resources

About