Prognostic Nutritional Index (PNI) Predicts Tumor Recurrence of Very Early/Early Stage Hepatocellular Carcinoma After Surgical Resection

Chan, Anthony Wing–Hung; Chan, Stephen L.; Wong, Grace Lai–Hung; Wong, Vincent W. S.; Chong, Charing Ching‐Ning; Lai, Paul; To, Ka Fai

doi:10.1245/s10434-015-4516-1

Cited by 226 publications

(240 citation statements)

References 32 publications

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“…Until now, the association between low PNI and poor clinical outcome has been proved in various malignancies, such as gastric cancer, colorectal carcinoma, pancreatic cancer, and hepatocellular carcinoma, as we have mentioned before [21][22][23][24]. However, few studies are available regarding PNI in esophageal cancer, and its role in esophageal cancer is still controversial.…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of systemic inflammation score in esophageal squamous cell carcinoma

et al. 2015

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The objective of this study was to investigate the clinical significance of systemic inflammation score (SIS) and prognostic nutritional index (PNI) in esophageal squamous cell carcinoma (ESCC) patients who underwent esophagectomy. Records from 206 patients with histologically diagnosed ESCC who underwent esophagectomy at Qilu Hospital of Shandong University from January 2007 to December 2008 were retrospectively reviewed. The median disease-free survival (DFS) of this cohort was 32.3 months and 5-year DFS was 34.5 %. The median overall survival (OS) was 39.5 months and 5-year OS was 40.8 %. We found that high SIS was significantly associated with increased tumor length (p = 0.021), increased depth of invasion (p = 0.001), lymph node metastasis (p = 0.038), and advanced pathological stage (p = 0.004). Kaplan-Meier survival analysis revealed that both high SIS and low PNI were significantly associated with inferior DFS (for the SIS, p = 0.005; for the PNI, p = 0.003) and OS (for the SIS, p = 0.007; for the PNI, p = 0.002). In multivariate analysis, SIS was an independent prognostic indicator for both DFS and OS. However, PNI was not an independent prognosticator in multivariate analysis. SIS was a novel and promising inflammation-based prognostic score than PNI in ESCC patients who underwent esophagectomy.

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Section: Discussionmentioning

confidence: 99%

The clinical significance of systemic inflammation score in esophageal squamous cell carcinoma

et al. 2015

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“…During the past decades, an increasing number of investigators focused on the relationship of inflammation with cancer prognosis. Inflammation-based scores including a combination of serum C-reactive protein and ALB as the Glasgow prognostic score were proven to be associated with survival in various cancers [14, 15, 24, 25]. It suggested that the ALB level might correlate with systematic inflammation [26].…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Prediction Role of Preoperative Serum Albumin Level in Patients with Intahepatic Cholangiocarcinoma Following Hepatectomy

Shen

Wen

et al. 2018

Dig Dis

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Background: There is little information regarding the role of preoperative serum albumin (ALB) in intrahepatic cholangiocarcinoma (ICC) patients who underwent liver resection. Methods: Clinicopathological characteristics and survival rate of 91 ICC patients who underwent surgery between 2009 and 2013 were included in this study. The optimal cut-off for ALB were determined by plotting the receiver operating characteristics curves of ALB in predicting overall survival (OS) and utilizing the Youden index. Long-term outcome was calculated by Kaplan-meire method. Results: The pathological characteristics were similar in both groups. The 1- and 3-year disease-free survival (DFS) rates between the high ALB group and the lower ALB group were 62.7 vs. 25.5% and 27.0 vs. 11.1% respectively (p < 0.001). The 1- and 3-year OS rates between the high ALB group and the lower ALB group were 78.4 vs. 57.5% and 42.6 vs. 6.7% respectively (p < 0.001). The ALB level as continuous variable in multivariate analysis remained a favorable factor for DFS and OS (p < 0.05). Furthermore, ALB could distinguish the prognoses in non-cirrhotic patients. Multivariate analysis showed other pathological risk factors like lymph node involvement, positive surgical margin, satellite lesions, and carbohydrate antigen 19-9 were associated with DFS and OS (p < 0.05 for all). Conclusions: A higher preoperative serum ALB level is associated with better long-term survival in ICC patients.

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“…Albumin also has a variety of well-studied effects, in addition to regulation of plasma colloid osmotic pressure. These include transportation of hormones, fatty acids and drugs, and also antiinflammatory, antioxidant activity and protection against ischemic damage (34)(35)(36)(37)(38)(39)(40)(41)(42), and it may even be involved in TGFβ-mediated growth control (43). Low albumin is associated with enhanced inflammation, whereas albumin therapy in cirrhotic patients can suppress hepatic inflammation (44,45).…”

Section: Discussionmentioning

confidence: 99%

Serum Albumin Levels in Relation to Tumor Parameters in Hepatocellular Carcinoma Patients

Carr

Guerra

2017

Int J Biol Markers

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ORIGINAL RESEARCH ARTICLEFurthermore, albumin values have been used in the 2-parameter albumin-bilirubin (ALBI) quantitative grading system for liver function in HCC, which has in turn been incorporated into several staging systems (21-25). There is thus much recent interest in serum albumin levels in prognostication, mainly as a reflection of liver function in HCC. However, there is also some direct experimental evidence that increased albumin levels can actually suppress HCC cell growth (26,27). Viewed this way, albumin levels may influence prognosis as much by their actions on HCC biology as by their reflection of impaired liver function.In this study, we examined the clinical correlations of serum albumin levels in a large HCC patient cohort with parameters of HCC behavior, and found an inverse relationship between serum albumin levels and HCC aggressiveness. Methods Patient dataWe retrospectively analyzed a prospectively collected database of 4,139 HCC patients, as previously reported (28,29), who had full baseline tumor parameter data, including computed axial tomography (CT) scan information on HCC size, number of tumor nodules and presence of PVT and plasma AFP levels; complete blood counts; routine blood liver function tests (total bilirubin, γ-glutamyl transpeptidase [GGT] and albumin); and patient demographics. Database management conformed to legislation on privacy, and this study conformed to the ethical guidelines of the Declaration of Helsinki. Approval for this retrospective study

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Prognostic Nutritional Index (PNI) Predicts Tumor Recurrence of Very Early/Early Stage Hepatocellular Carcinoma After Surgical Resection

Abstract: The PNI is a significant prognostic factor for OS and DFS of patients with very early/early stage HCC receiving curative surgery.

Cited by 226 publications

References 32 publications

The clinical significance of systemic inflammation score in esophageal squamous cell carcinoma

The clinical significance of systemic inflammation score in esophageal squamous cell carcinoma

The Prognostic Prediction Role of Preoperative Serum Albumin Level in Patients with Intahepatic Cholangiocarcinoma Following Hepatectomy

Serum Albumin Levels in Relation to Tumor Parameters in Hepatocellular Carcinoma Patients

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