Prognostic Nutritional Index Predicts Morbidity After Curative Surgery for Colorectal Cancer

Bailon-Cuadrado, M.; Pérez-Saborido, B.; Sánchez‐González, Javier; Rodríguez-López, M.; Velasco-López, Rosalía; Sarmentero-Prieto, José C.; Blanco-Álvarez, José I.; Pacheco-Sánchez, D.

doi:10.1016/j.cireng.2019.01.003

Cited by 13 publications

(12 citation statements)

References 44 publications

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“…The PNI is normally used to evaluate perioperative risk and nutritional status of patients prior to gastrointestinal surgery ( Migita et al, 2013 ; Onodera, Goseki & Kosaki, 1984 ). Many recent studies have shown that a low PNI is an independent risk factor of poor prognosis in patients with colorectal cancer ( Bailón-Cuadrado et al, 2019 ; Sasaki et al, 2019 ). The CONUT score is a newly proposed index to evaluate the immune nutritional status of patients.…”

Section: Discussionmentioning

confidence: 99%

The Significance of the preoperative lactate dehydrogenase/albumin Ratio in the Prognosis of Colon Cancer: a retrospective study

Xie

Zhou

Wang

et al. 2022

PeerJ

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Background We explored the relationship between the platelet-lymphocyte ratio (PLR), the prognostic nutritional index (PNI), the lactate dehydrogenase-albumin ratio (LDH/albumin ratio; LAR), the controlling nutritional status (CONUT) score, and the long-term survival of colon cancer patients. Methods We conducted a retrospective analysis of the clinical data and follow-up materials of 126 patients with colon cancer who underwent surgical treatment in the Department of Gastrointestinal Surgery of Jiangnan University Affiliated Hospital from June 2012 to December 2015. The receiver operating characteristic curve (ROC) was used to distinguish the high ratio group from the low ratio group. The Kaplan Meier method was used to draw the survival curve in our survival analysis. The log rank test was used for the univariate analysis and the Cox multivariate regression analysis was used to analyze the correlation between preoperative PLR, PNI, LAR, conut scores, and overall survival (OS) and progression free survival (PFS) of patients with colon cancer. Results The median follow-up time was 72 months. The OS rates at 3 and 5 years were 83.3% and 78.5%, respectively. The PFS rates at 3 and 5 years were 79.3% and 77.6%, respectively. The 3-year and 5-year OS rates in the low LAR group (≤4.91) were 90.9% and 87.1%, respectively, and were 56.0% and 44.0% in the high LAR group (>4.91) respectively. Univariate and multivariate analyses showed that the LAR value was correlated with OS and PFS (P < 0.05). Conclusion A high preoperative LAR is an independent predictor of the prognosis of colon cancer patients.

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Section: Discussionmentioning

confidence: 99%

The Significance of the preoperative lactate dehydrogenase/albumin Ratio in the Prognosis of Colon Cancer: a retrospective study

Xie

Zhou

Wang

et al. 2022

PeerJ

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“…Namely, studies on the prognostic significance of PNI for the occurrence of complications in patients with various carcinomas were mainly conducted in the patients who underwent surgery. In general, most authors agree that low preoperative PNI can predict postoperative complications, such as pneumonia, urinary and wound infection, anastomotic leakage, bleeding [41][42][43][44][45][46][47].…”

Section: Discussionmentioning

confidence: 99%

The Usefulness of Prognostic Nutritional Index in Predicting Infection in Patients with Newly Diagnosed Pancreatic Cancer

Manojlovic

2021

BJSTR

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Background/Aims: Data on the usefulness of prognostic nutritional index (PNI) in predicting infection in patients with pancreatic cancer before oncological treatment are limited. The aim of this study was to investigate the usefulness of PNI in predicting infection in patients with newly diagnosed pancreatic cancer. Methods:The retrospective study included 59 adult patients. We recorded clinicopathological characteristics and laboratory analysis on admission and infectious complications that occurred during hospitalization. PNI was calculated using albumin and lymphocyte count. Association with infective complication was tested for the age, sex, body mass index, albumin levels, lymphocyte count, PNI, PNI<40.5, serum carbohydrate and carcinoembryonic antigen, tumour location, the existence of metastases and hospitalization length.Results: In the analysed series, there were 36 (61%) male and 23 (39%) female patients; mean age was 62.5 years. Infectious complications were detected in 25 (42,4%) patients. Three factors were found to be associated with infectious complications (Binary logistic regression): serum albumin level (P=0.019), PNI (P=0.030) and PNI below 40.5 (P=0.026). ROC curve analysis determined PNI=39.5 as a new cut-off value for the occurrence of complications, but with relatively low sensitivity (40%) and specificity (38.2%). Conclusion:Low serum albumin concentration and PNI could represent risk factors for infection in patients with newly diagnosed pancreatic cancer.

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“…According to Banysch et al, colorectal surgery may be safely performed in patients past the age of 80 if the ASA status is good and there are no grave comorbid conditions [16]. Other sources have also claimed that lower BMI imparts high risk in the elderly population [17], and that low PNI heightens risks of postoperative complications and mortality after colorectal cancer surgery [18,19]. Unfortunately, many ambigui- ties exist with regard to the types of patients warranting special perioperative attention and specific measures to reduce surgical risks.…”

Section: Discussionmentioning

confidence: 99%

E-PASS Scoring System May Be Useful for Prediction of Postoperative Complications in Super Elderly Colorectal Cancer Surgery Patients

Kondo

Hirano

Ishii

et al. 2020

J Anus Rectum Colon

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Objectives: Japan is facing an aging society. Elderly individuals are generally more prone to comorbidities and have weaker immune defenses, with ominous prognostic implications if postoperative complications arise. The aim of this study was to explore scoring systems for predicting postoperative morbidity risk in super elderly patients (! 85 years old) after colorectal surgery for cancer. Methods: A population of elderly patients (n = 145) surgically treated for primary colorectal cancer within our department between April 2007 and December 2018 was examined retrospectively, assessing the capacities of various indices, such as Estimation of Physiologic Ability and Surgical Stress (E-PASS), neutrophil/ lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), prognostic nutritional index (PNI), and modified Glasgow Prognostic Score (mGPS), to predict postoperative complications. Results: NLR, PLR, and mGPS did not differ significantly in the presence or absence of complications, whereas PNI tended to be lower if complications developed. The E-PASS system showed no group-wise differences in preoperative risk score (PRS), but the surgical stress score (SSS) and the comprehensive risk score (CRS; a composite of PRS and SSS) was significantly higher in patients with complications. Based on the cutoff value calculated from the Receiver operating curve (ROC) for the E-PASS CRS (−0.0580), patients were stratified into low-scoring and high-scoring (HSG) groups. Although not significantly different, the overall survival in the HSG tended to be lower by comparison. Conclusions: The E-PASS scoring system may be a useful predictor of postoperative complications in super elderly patients requiring colorectal cancer surgery.

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Prognostic Nutritional Index Predicts Morbidity After Curative Surgery for Colorectal Cancer

Cited by 13 publications

References 44 publications

The Significance of the preoperative lactate dehydrogenase/albumin Ratio in the Prognosis of Colon Cancer: a retrospective study

The Significance of the preoperative lactate dehydrogenase/albumin Ratio in the Prognosis of Colon Cancer: a retrospective study

The Usefulness of Prognostic Nutritional Index in Predicting Infection in Patients with Newly Diagnosed Pancreatic Cancer

E-PASS Scoring System May Be Useful for Prediction of Postoperative Complications in Super Elderly Colorectal Cancer Surgery Patients

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