Prognostic Performance of a New Staging Category to Improve Discrimination of Disease-Specific Survival in Nonmetastatic Oral Cancer

Abstract

In this study, new staging category had better DSS discriminatory ability and could help to identify high-risk patients for intense adjuvant therapy.

Meta‐analysis of the prognostic value of the neutrophil‐to‐lymphocyte ratio in oral squamous cell carcinoma

“…That Tsai obtained non‐significant results when the cutoff for NLR was set at 5 suggests the optimal cutoff value should <5 for oral cancers. Interestingly, a significant association was observed between NLR and TNM stage in oral cancers . In our study, however, most cases were not advanced stage cancers, which may also explain why the optimal cutoff for NLR varied.…”

“…At present, the prognosis and treatment of OSCC are based mainly on the American Joint Committee on Cancer (AJCC) TNM classification which was based on tumor's size, spread to lymph nodes and metastasis . However, a major limitation of this classification is that it is not perfectly accurate, and a combination of other factors is more predictive of prognosis than traditional tumor staging in patients with OSCC …”

“…These inflammation markers are not only easy to acquire; they also have strong predictive value with oncologic patients . Several studies have investigated the use of inflammatory markers as indicators to predict OSCC progression . However, the results of these studies regarding use of the NLR as a prognostic marker for OSCC are controversial, due largely to the limited sample sizes and variation in study designs.…”

Neutrophil‐to‐lymphocyte ratio as a prognostic indicator in head and neck cancer: A systematic review and meta‐analysis

“…Recently, novel prognostic systems have been developed incorporating NLR, such as the combination of NLR and platelet counts in hypopharyngeal cancer, or histopathological staging and NLR in oral cancer . Other inflammatory markers and systems, such as the platelet‐to‐lymphocyte ratio, lymphocyte‐to‐monocyte ratio, and Glasgow Prognostic Score have also received interest as prognostic indicators in head and neck cancer.…”

“…The PRISMA flow chart of the systematic review can be found in Figure . An initial search done using the search strategy (Supporting Materials) obtained an initial 900 results.…”