Prognostic Relationship Between Two Serial Determinations of B-type Natriuretic Peptide and Medium–Long-term Events in Heart Transplantation

The Change in B-Type Natriuretic Peptide Levels Over Time Predicts Significant Rejection in Cardiac Transplant Recipients

“…16 Finally, a recent study of 71 heart transplant recipients determined that a 20% increase in BNP levels between 9 and 12 months after transplant was associated with an increased risk of death, rejection, or graft dysfunction during the follow-up period. 28 The present findings confirm those of other studies, extending them to include a larger number of patients and BNP observations, as well as indicating a graded relationship in the association between within-individual increases in BNP and rejection.…”

Diffuse myocardial fibrosis among healthy pediatric heart transplant recipients: Correlation of histology, cardiovascular magnetic resonance, and clinical phenotype

“…Our cohort was relatively healthy, as demonstrated by low BNP values, normal group mean filling pressures, minimal presence of donor‐specific antibodies, low prevalence of CAV, and normal clinical evaluations with no symptoms of heart failure. While most BNPs we observed were normal, data from the adult HT population show prognostic relevance of BNP reported values across a similar range . Because most of our cohort received HT more than 10 years ago, the clinical biopsy reports lack sufficient detail to allow us to explore possible associations of ECV with antibody‐mediated rejection history.…”

Repeated Measurements of NT-pro-B-Type Natriuretic Peptide, Troponin T or C-Reactive Protein Do Not Predict Future Allograft Rejection in Heart Transplant Recipients

“…Few studies have examined prognostic value of repeated measurements of NT-proBNP or BNP for AR. Arora et al 9 examined changes in NT-proBNP and did not find any association with acute cellular rejection, whereas Garrido et al, 8 Kittleson et al, 7 Martinez-Dolz et al, 28 and Damodaran et al 29 found positive associations between changes in BNP and NT-proBNP and AR. None of these prognostic studies have used all the available biomarker measurements in their analyses.…”